Nilay Taneja

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...

🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Link to pdf:
www.biorxiv.org/content/10.1...

Me arranging my data into a story. Spoiler alert- this cell never went past metaphase

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.

www.biorxiv.org/content/10.1...

Actin obsession series 3. Dividing HeLa cell #FluorescenceFriday

🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors

pubs.aip.org/aip/apr/arti...

Actin obsession series 2. Actomyosin cortex of a blebbing M2 melanoma cell. #FluorescenceFriday

Program and application instructions for the 2025 Mechanobiology of tissue morphogenesis and disease workshop in Baeza, Spain, October 21-23. Apply at https://www.unia.es/estudios-y-acceso/oferta-academica/formacion-continua/workshop-mechanobiology-of-tissue-morphogenesis-and-disease

Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!

Actin obsession series: 1. Actin cytoskeleton in membrane ruffles at the leading edge of a crawling cancer cell

Check out our latest study from the lab!

(PDF) Beyond mechanosensing: How cells sense and shape their physical environment during development PDF | The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in... | Find, read and cite all the research you need on Rese...

Read more about it at:
doi.org/10.1016/j.ce...

We are excited to share our recent preprint on how tissue spreading guides extracellular matrix changes during early morphogenesis @gurdoninstitute.bsky.social

Force-insensitive myosin-I enhances endocytosis robustness through actin network-scale collective ratcheting Force production by Type-I myosins influences endocytic progression in many cell types. Since different myosin-I isoforms exhibit distinct force-dependent kinetic properties, it is important to invest...

Congrats to my fantastic coauthors on this work with a surprising conclusion. www.biorxiv.org/content/10.1...

Ever wondered how organs take shape? Join us to find out!
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏

Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis Xenopus epithelial cells mechanosensitively reinforce connections to neighbor cells during cytokinesis. Here, Landino et al. show that actomyosin arrays assembled in neighbor cells restrain cytokineti...

I'm so pleased the final version of this research is published! We found that epithelial cells neighoring the cytokinetic furrow regulate the speed and sucess of cell division, while maintaining barrier function and cell packing geometry. Many thanks to the co-authors who contributed! 🐸 #xenopus