γδ T cell Forum forum-gd - Bluesky Statics

GFI1 as a novel regulator of γδ T cell development and the IL-17/IFNγ lineage commitment GFI1 is a DNA-binding zinc finger transcription factor regulating the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in γδ T cells and restricts the cellularity of RORγt+Vγ6+ γδT cells that produce high levels of IL-17A, while promoting the expansion of Vγ1+ and Vγ4+ γδT cells. Absence of GFI1 results in a pronounced bias toward the production of γδT17 cells, commencing post-birth. Additionally, we observe an expansion of RORγt+/MAF+ cells within the thymic DN1e population of GFI1-deficient mice. The DN1e population, along with other DN subsets in GFI1 knock-out (KO) mice, exhibits a distinctive γδT17 cell-specific transcriptomic profile. Specifically, DN1, DN3, and γδ T cells lacking GFI1 show upregulation of the B-ZIP transcription factor MAF, which regulates genes critical for γδT cells, such as Il17a, Il22, and Blk that are all induced in Gfi1 deficient cells. The Maf gene is occupied by GFI1 in DN pre-T cells at cognate binding sites in its promoter region, suggesting that GFI1 acts as a direct repressor of Maf. We conclude that GFI1 functions as a novel regulator of Vγ6+ γδT17 precursor cells restricting their peripheral expansion by acting upstream of a MAF dependent regulatory network. ### Competing Interest Statement The authors have declared no competing interest. Canadian Institutes of Health Research, https://ror.org/01gavpb45, FDN - 148372

www.biorxiv.org/content/10.6...

01.03.2026 02:36 — 👍 2 🔁 0 💬 0 📌 0

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and ...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight

#gdTcells @bsilvasantos.bsky.social

28.02.2026 12:48 — 👍 1 🔁 1 💬 0 📌 0

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection TCRγδ+ intraepithelial lymphocytes (γδIELs) are crucial for maintaining intestinal homeostasis, yet their functional regulation remains incompletely u…

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

#gdTcells @cp-immunity.bsky.social

27.02.2026 12:04 — 👍 4 🔁 2 💬 0 📌 0

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

#gdTcells @nature.com

27.02.2026 12:03 — 👍 2 🔁 0 💬 0 📌 1

www.sciencedirect.com/science/arti...

23.02.2026 17:33 — 👍 2 🔁 0 💬 0 📌 0

journals.lww.com/amjclinicalo...

23.02.2026 17:32 — 👍 0 🔁 0 💬 0 📌 0

Frontiers | The gamma delta T/NK cell product GADEKILL as a novel immunotherapeutic tool for neuroblastoma patients: role of B7H6 and BTN2A1 in tumor cell killing BackgroundAnti-GD2 monoclonal antibody effectively treats high-risk neuroblastoma (HR-NB) by recruiting NK cells for antibody-dependent cellular cytotoxicity...

www.frontiersin.org/journals/imm...

23.02.2026 17:32 — 👍 3 🔁 1 💬 0 📌 0

Adoptive γδ T cell therapy controls cytomegalovirus infection in preclinical transplantation models - Nature Communications Gamma delta T cells as a therapeutic strategy have shown great promise in a range of contexts. Here the authors explore the use of a gamma delta T cell therapy in experimental models of cytomegaloviru...

www.nature.com/articles/s41...

Congrats to Gabriel Marseres et al.

23.02.2026 16:37 — 👍 4 🔁 0 💬 0 📌 0

Join us for our March #GDTcellclub webinar talks with Drs. Judith Wienke (Utrecht) and Monika Wolkers (Sanguine BSF) on March 19 at 12pm NY time.

Zoom ID: 958 9051 7066/ passcode 369081

nyulangone.zoom.us/j/9589051706...

17.02.2026 02:11 — 👍 14 🔁 5 💬 0 📌 0

Join us for our March #GDTcellclub webinar talks with Drs. Judith Wienke (Utrecht) and Monika Wolkers (Sanguine BSF) on March 19 at 12pm NY time.

Zoom ID: 958 9051 7066/ passcode 369081

nyulangone.zoom.us/j/9589051706...

17.02.2026 02:11 — 👍 14 🔁 5 💬 0 📌 0

γδ T cell, αβ T cell and B cell

15.02.2026 18:11 — 👍 5 🔁 1 💬 0 📌 0

Computational Postdoc | Netherlands Cancer Institute Computational Postdoc Voest Lab (fully funded) — Spatial Decoding of Unconventional Antitumor Immunity in Colorectal Cancer

Postdoc alert in spatial biology!

Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.

Learn more / apply here: www.nki.nl/careers-stud...

15.02.2026 18:59 — 👍 11 🔁 13 💬 3 📌 0

γδ T cell, αβ T cell and B cell

15.02.2026 18:11 — 👍 5 🔁 1 💬 0 📌 0

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

15.02.2026 18:08 — 👍 0 🔁 0 💬 0 📌 0

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases The immune microenvironment of the male genitourinary tract is orchestrated by immune cells including unconventional T cells, which mainly consist of γδ T cells, natural killer T (NKT) cells, and muc...

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases

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15.02.2026 18:06 — 👍 0 🔁 0 💬 0 📌 0

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function The human TCRγδ constant region modulates T cell activation and corresponds with T cell clonal expansion and function.

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function

#gdTcells @sciimmunology.bsky.social

14.02.2026 23:23 — 👍 4 🔁 0 💬 1 📌 0

Structural biology of γδ T cell receptors T cell receptor (TCR) diversity underpins cellular immunity. While αβ TCRs have been extensively studied in the context of major histocompatibility co…

Structural biology of γδ T cell receptors

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14.02.2026 23:22 — 👍 6 🔁 2 💬 0 📌 0

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16.11.2024 00:20 — 👍 34 🔁 13 💬 31 📌 4

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy In this opinion article, Silva-Santos et al. discuss the potential of Vδ1+ γδ T cells for cancer immunotherapy, focusing on DOT cells. These in vitro–expan

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

#gdTcells @jem.org

12.02.2026 11:15 — 👍 5 🔁 1 💬 0 📌 0

Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis - Nature Communications Sex dimorphism in the incidence and mortality of hepatocellular carcinoma (HCC) has been reported. Here the authors show that, in males, androgen promotes regulatory T cell recruitment to impair γδ T ...

Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

#gdTcells @natcomms.nature.com

12.02.2026 11:14 — 👍 1 🔁 0 💬 0 📌 0

JCI Insight - Ex vivo expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal

Ex vivo expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal

#gdTcells @insight.jci.org

11.02.2026 11:45 — 👍 2 🔁 1 💬 0 📌 0

Very cool work from the Beattie lab. Beautiful experiments. #Immunology @forum-gd.bsky.social

08.02.2026 16:11 — 👍 5 🔁 2 💬 0 📌 0

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response.

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis

#gdTcells @sciimmunology.bsky.social

07.02.2026 12:06 — 👍 2 🔁 0 💬 0 📌 0

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells Author summary Malaria remains one of the deadliest infectious diseases, disproportionately affecting young children in sub-Saharan Africa who succumb to sequelae of Plasmodium falciparum infection. H...

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells

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04.02.2026 11:22 — 👍 0 🔁 0 💬 0 📌 0

Happy Sunday!

ICYMI #GDTcells

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link.springer.com/article/10.1...

onlinelibrary.wiley.com/doi/10.1111/...

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01.02.2026 15:14 — 👍 3 🔁 0 💬 0 📌 0

Peer review and publishing at eLife · eLife eLife is pioneering an approach to scientific publishing that combines the immediacy and openness of preprints with the scrutiny of peer review by experts.

When you publish with eLife, you have full control over how you revise after peer review, giving you more agency over the direction of your work.

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31.01.2026 23:44 — 👍 6 🔁 2 💬 0 📌 0

γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

γδ T cell-derived IL-4 initiates CD8+ T cell immunity

#gdTcells @natimmunol.nature.com

31.01.2026 20:28 — 👍 11 🔁 4 💬 0 📌 0

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia Key Points. The vast majority of TCRγδ+ T-ALLs express homeodomain-containing (HD+) oncogenes and display features of pre-αβ cortical thymocytes.Overexpres

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia

#gdTcells @bloodjournals.hematology.org

28.01.2026 16:01 — 👍 4 🔁 0 💬 0 📌 0

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma Background Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various can...

jitc.bmj.com/content/14/1...

From Kilian Wistuba-Hamprecht lab

26.01.2026 21:14 — 👍 7 🔁 3 💬 0 📌 0

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in... While regulatory T cells (Tregs) control autoimmune diseases (AID), the role of evolutionarily older Foxp3+ γδTregs is much less understood. We noted that both lesional and non-lesional skin of patien...

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo

#gdTcells

25.01.2026 11:19 — 👍 8 🔁 1 💬 0 📌 0

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