γδ T cell Forum

easily, one of my favorite people ever.. AND she works on #gdtcells...

go work work Karen!! @edelblumlab.bsky.social

👇👇👇

With great joy, we celebrated @saraalonsomera.bsky.social’s
last day in the lab and recent acceptance of her paper @mucosalimmunol.bsky.social! 🥳🍾 We wish her the best of luck as a postdoc at NYU working with @rkzwick.bsky.social, where we know she’ll make us proud 😍. #gdTcells #GIresearch #proudPI

I'll take #gdTcells for $500

Antibody-like recognition of a γδ T cell receptor toward a foreign antigen Rashleigh et al. utilized phycoerythrin, a bacterial derived protein, to explore immune reactivity of B cells, αβ T cells, and γδ T cells. All lymphocytes directly recognized PE, while T cell recognit...

Excited to get some of my PhD work published! Utilising single particle cryo-EM we display convergent recognition by three lineages of lymphocyte to the same epitope.

#gdTcells #CryoEM

Post Doctoral Fellow-MSH-20093-003 in New York, NY | Mount Sinai Health Systems Mount Sinai is hiring a Post Doctoral Fellow-MSH-20093-003 in New York, NY. Review all of the job details and apply today!

🚨Postdoc position available! We're looking for recent immunology PhD graduates interested in studying #gdTcells & #IELs in #IBD to join our team at Mount Sinai. Sinai has high stipends and a great location next to Central Park 🤩 #GIsky #IBDsky #Immunosky careers.mountsinai.org/jobs/3029365...

Immune cell landscape in a human decedent receiving a pig liver xenograft - Nature Medicine Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce...

Immune cell landscape in a human decedent receiving a pig liver xenograft

#gdTcells

Did you miss @eberlmat.bsky.social at the last #GDTCellclub seminar? He's been single handedly trying to teach Microbiology to the future generations.. one @superbugs.bsky.social at a time. Check this out👇👇

Characteristics and significance of γδ T cells in colorectal cancer Gamma-delta T cells are a subset of T cells that have features of both innate and adaptive immunity. Their role in cancer remains controversial, since both anti- and protumor functions have been re...

Characteristics and significance of γδ T cells in colorectal cancer

#gdTcells

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice - Nature Communications Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meni...

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

#gdTcells @natcomms.nature.com

@yusankao.bsky.social shared her awesome work on metabolism of gd T cells in psoriasis! Check it out here if you missed it live 👇

If you missed it, here's a recording from today's #GDTcellclub seminar by Dr. Yu-San Kao from Princeton University (Lydia Lynch Lab).

nyulangone.zoom.us/rec/share/y-...

Passcode: #GDTcellclubJuly2025

Please reach out to Dr. Kao for burning questions from the talk.

Happening now, join us!!

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling - PubMed Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

#gdTcells @mucosalimmunol.bsky.social @edelblumlab.bsky.social

pubmed.ncbi.nlm.nih.gov/40683453

oin us tomorrow for our next #GDTcellclub webinar - featuring Dr Yu-San Kao talking about metabolism of gamma delta T cells during inflammation.

12pm EST - July 24th

Zoom ID: 958 9051, Passcode: 369081
nyulangone.zoom.us/j/9589051706...

Congrats to all the awardees. It was such a delight to welcome the community to #gammadeltatoronto #gd2025 and see these bidding scientists in action! Thanks @aai.org for supporting #GDTcell research

PhD Scholarships in Immunology and Cancer Immunotherapy - DTU Health Tech Two fully funded PhD positions starting between Jan and Feb 2026. The project is focused on understanding what is the impact of immune checkpoint blockade therapy on the biology of γδ T cells and how ...

Please Repost!

PhD Scholarships in Immunology and Cancer Immunotherapy - DTU Health Tech

efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

on behalf of @vasgdtcells.bsky.social

IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages - Nature Cancer Petroni et al. report that the infiltration of IL-17A-secreting γδ T cells in the tumor microenvironment coupled with the accumulation of immunosuppressive macrophages is associated with resistance to...

IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2- breast cancer via CX3CR1+ macrophages

#gdTcells @natcancer.nature.com

www.researchsquare.com/article/rs-6...

Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid

Serum levels oleic acid vs palmitic acid correlate with efficacy of Vg9Vd2 therapy efficacy due to palmitic acid inducing pyroptosis in gd T cells, which can be rescued by oleic acid.

#gdTcells www.nature.com/articles/s41...

Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection - Nature Communications The interplay between the immune system and the HIV reservoir is incompletely understood. Here the authors show a dual role of Vδ1 T cells in control and contribution of HIV-1 persistence and to the t...

Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection

#gdTcells @natcomms.nature.com

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis - Nature Immunology Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 in restricting type 1 plasticity.

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

#gdTcells @natimmunol.nature.com

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer - Nature Cancer Silva-Santos and colleagues provide in vivo preclinical evidence supporting a therapeutic use of Delta One T cells to tackle colorectal cancer and propose activating natural killer cell receptor NKG2D...

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

#gdTcells @natcancer.nature.com

Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines AbstractMotivation. The analysis of complex biomedical datasets is becoming central to understanding disease mechanisms, aiding risk stratification and gui

"Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines"

Now available @bioinfoadv.bsky.social.

An amazing collaboration between @cusystemsimmu.bsky.social, @newcastleuni.bsky.social and @leedsbeckett.bsky.social!

🤒🔬🧑🏼‍💻📊

Video Conferencing, Web Conferencing, Webinars, Screen Sharing Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

For anyone who missed today's talks, find the recording here: mit.zoom.us/rec/share/q6...
Passcode: koay_roring_June25

If you have any questions for @fernery.bsky.social or @therealmonocyte.bsky.social after watching then feel free to ask here!

Next up is Dr Rutger Roring presenting on trained immunity in gd T cells in response to vaccination.

Our first talk today, Dr Hui-Fern Koay is talking about purinergic sensing by innate T cells.

Been craving your next gd fix after the conference in Tornonto? Join us today for our next #GDTcellclub webinar with two brilliant speakers - Dr Hui-Fern Koay and Dr Rutger J. Roring!

Tune in June 19th 7pm NY - June 20th 9am Melbourne. We will be recording for those who cannot attend live.

#GDTcellclub Webinar Series - Feedback Want to see the program for the gd T cell webinar series for the rest of this year? Answer a few simple questions to find out! (link comes up after submission) We'd love to hear your thoughts, speake...

Hi! We are trying to get more insights on how to improve the #GDTcellclub series and would really like your support. Please fill out this form and help us improve your experience

Please and thank you

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@clairemci.bsky.social @eberlmat.bsky.social @forum-gd.bsky.social

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation Vγ9Vδ2 T cells, the major circulating human γδ T cell subset, respond to infections and tumors by recognizing phosphoantigens (pAgs) via transmembrane…

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

#gdTcells @cp-immunity.bsky.social

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation Vγ9Vδ2 T cells, the major circulating human γδ T cell subset, respond to infections and tumors by recognizing phosphoantigens (pAgs) via transmembrane…

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

#gdTcells @cp-immunity.bsky.social