γδ T cell Forum

IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice

#gdTcells @jci.org

A triple take on antigen receptor recognition of PE In this issue of Structure, Rashleigh et al. used cryoelectron microscopy to assess recognition of the model foreign antigen phycoerythrin (PE) by a γδTCR, an αβTCR, and an antibody. With potential re...

A triple take on antigen receptor recognition of PE

#gdTcells

Antibody-like recognition of a γδ T cell receptor toward a foreign antigen Rashleigh et al. utilized phycoerythrin, a bacterial derived protein, to explore immune reactivity of B cells, αβ T cells, and γδ T cells. All lymphocytes directly recognized PE, while T cell recognit...

Antibody-like recognition of a γδ T cell receptor toward a foreign antigen

#gdTcells

Microbial metabolic pathways guide response to immune checkpoint blockade therapy

#gdTcells

Post Doctoral Fellow-MSH-20093-003 in New York, NY | Mount Sinai Health Systems Mount Sinai is hiring a Post Doctoral Fellow-MSH-20093-003 in New York, NY. Review all of the job details and apply today!

👀 We're on the lookout for a talented immunologist to join us for a postdoc at Mount Sinai! If you are a recent PhD graduate, love spectral flow and want to join our γδ T cell crew, apply below! Livable wage + subsidized housing + Central Park. Help us spread the word! #gdTcells #Immunosky #GISky

γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low...

our study on #gdTcells in pediatric neuroblastoma is out! In contrast to adult tumors, it is the gdTcells that not only expand, but that are the most tumor reactive #TILs.

#immunology #tumorimmunology

funded by KIKA, Sanquin and supported by Oncode

www.life-science-alliance.org/content/8/11...

γδT cells and breast cancer: wicked allies Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni …

check out our new commentary on 2 recently published papers about #gdTcells in breast cancer
www.sciencedirect.com/science/arti...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Human Vγ9/Vδ2 T cells display a unique responsiveness towards microbial organisms producing the metabolite HMB-PP. However, Staphylococcus aureus does not possess HMB-PP but can induce activation, cy...

"Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus"

To Armin and Martin. 🕯️

#gdTcells

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...

📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky

If you missed today's seminars by Drs. Inacio and Gonzalez, please see the recorded sessions here:

nyulangone.zoom.us/rec/share/Ai...
Passcode: GDTcellclub_Sept2025

Our next speaker is Dr Octavio Gonzalez, sharing his work on the impact of aging on gingival gd T cells.

Our second speaker, Dr. Octavio Duque will talk about the effect of aging on gingival gdTs. Please join us! #GDTcells

Join us now to hear from Dr Daniel Inácio about the molecular control of gd T cell subset differentiation and effector function.

Starting up with Dr. Daniel P. Inacio from Univ. of Lisbon about effector functions of #GDTcells.. join us!

Please join us for the upcoming September #GDTcellclub Virtual talks by Drs. Daniel P. Inacio and Octavio A. Gonzalez on Sept 18 at 12pm NY/5pm Lisbon

Bookmark for up-to-date announcements 👇
payalyokota.com/gamma-delta-...

Zoom: nyulangone.zoom.us/j/9589051706...

@forum-gd.bsky.social

Join us tomorrow for our next #GDTcellclub webinar, where we are delighted to host Drs Octavio Gonzalez and Daniel Inácio.

Date: September 18, 2025
Time: 12pm (New York) | 5pm (London, UK)

nyulangone.zoom.us/j/9589051706...

*Talks will be recorded* for those who are unable to attend live.

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming Ocular commensal C. mast induces IL-17 responses from Vγ6 T cells, helping to maintain mucosal barrier function of the conjunctiva. Mechanistically, Vγ6 T

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

#gdTcells @jem.org

Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy Author summary Vδ1 T cells are key immune cells, particularly in the intestinal mucosa, which is a major site of HIV-1 persistence during antiretroviral therapy. Disruption of the gut microenvironment...

Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy

#gdTcells

Metabolic control of innate-like T cells - Nature Reviews Immunology Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...

Metabolic control of innate-like T cells

#gdTcells @natrevimmunol.nature.com

Phenoscaping Reveals Multimodal γδ T Cell Cytotoxicity as a Strategy to Overcome Cancer Cell-Mediated Immunomodulation Open Access

#gdTcells @aacrjournals.bsky.social

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines Memory T cells drive early reactogenic responses to mRNA boosters via MAIT/innate-like T cells, which are tempered by dosing interval.

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines

#gdTcells

Don't miss the upcoming #Globalimmunotalk by Prof Adrian Hayday on August 27. I am sure it will be an absolute treat!

Talk Title: Lymphoid stress-surveillance, normality sensing, and integrated immunology.

Thank you again for joining us for the August 21, #GDTcellclub seminars by Drs. Amit Sharma and Xiaoyan Xu.

Here's a recording from today's talks:
nyulangone.zoom.us/rec/share/Wq...

Passcode: #GDTcellclubAug2125

Please feel free to post your questions by replying to this thread!

Next up today, we have Dr. Amit Sharma presenting his work on gd T cells in aging and fibrosis.

Our first speaker today is Dr. Xiaoyan Xu talking about the ocular gd T cell response to Corynebacterium mastitidis.

Starting in less than 30min, join us for two fantastic talks by Drs. Amit Sharma and Xiaoyan Xu today for our August #GDTcellclub seminar.

We can't wait to *see* you!
zoom information below

We are excited to host Drs. Amit Sharma and Xiaoyan Xu for our upcoming #GDTcellclub virtual talks.

Date: August 21, 2025
Time: 12pm (New York) | 5pm (London, UK)

nyulangone.zoom.us/j/9589051706...

*Talks will be recorded* for those who are unable to attend live.

Super excited to present Drs. XIaoyan Xu and Amit Sharma for our August 21st #GDTcellclub seminars.

Please tune in and look below for zoom info! 👇👇👇

Join our Cloud HD Video Meeting Zoom is the leader in modern enterprise cloud communications.

We're excited to host Dr. Xiaoyan Xu (NIH) and Dr. Amit Sharma (Sens Res Foundation) for our upcoming #GDTcellclub virtual seminars. Formal advert upcoming! Pls join us!

August 21st @ 12pm (EDT) | 5pm (GMT+1)
nyulangone.zoom.us/j/9589051706...

Zoom ID: 958 9051 7066        
Passcode: 369081

easily, one of my favorite people ever.. AND she works on #gdtcells...

go work work Karen!! @edelblumlab.bsky.social

👇👇👇