Adrian Saurin

The model is based on the fact that paclitaxel binds strongly to microtubules. It could also be relevant for other cancer drugs that bind strongly to abundant cellular targets, such as microtubules or DNA

Seeing a loved one roll the dice with drugs like this (as too many of us will) really hits home how little we know. That was the inspiration to get this idea out. We must learn how these drugs work if we are going to improve on them

A perfusion-based model to explain how paclitaxel achieves tumour-selective killing Paclitaxel (taxol) is a commonly used chemotherapeutic that stabilizes microtubules to inhibit chromosome segregation during mitosis. Although it is used effectively to treat a wide variety of solid t...

A simple idea for how paclitaxel achieves tumour selectivity: It is better retained inside dense tissue, allowing tumour levels to stay high even after it has cleared the healthy cells. A model that requires testing, but could be used to improve treatments if correct
www.biorxiv.org/content/10.1...

End GDP mania: how the world should really measure prosperity The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

“We have economies that need to grow, whether or not they make us thrive; what we need are economies that make us thrive, whether or not they grow.”

www.nature.com/articles/d41...

a man in a plaid shirt sits in front of a couch with london written on it ALT: a man in a plaid shirt sits in front of a couch with london written on it

Wow, a recruitment bonanza in the current climate? Magic!

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

depmap miner logo

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

The mitotic stopwatch limits the proliferation of whole genome doubled cells Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...

Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.

Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek

www.biorxiv.org/content/10.1...

Letter from Ed Davey to Keir Starmer condemning Elon Musk for inciting violence and urging unity to defend democracy.

I've written to Keir Starmer, Kemi Badenoch and Nigel Farage, urging them to join me in condemning Elon Musk's dangerous remarks inciting violence yesterday.

As leaders, we must stand together and make clear Musk will face serious consequences for these actions.

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

Research Technician – Protein Biochemistry at University of Sussex Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Mitotic single-stranded DNA suppression by DDIAS Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

Brilliant Alexis! Very pleased for you and very well deserved. 👏🍾

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...

Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org

Are you curious about what PLK1 kinase is up to these days? Have a look at our latest review on @cp-trendscellbio.bsky.social. Arianna Esposito Verza, @andrea-musacchio.bsky.social and I discuss the latest findings on a very important enzyme that is still full of surprises, 35+ years from discovery!

Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine During development, many cell types transition from canonical to non-canonical cell cycles, suchas endomitosis and endoreplication, in which they duplicate their DNA but do not divide, giving rise to ...

I'm excited to share our work on the regulation of endomitosis in worm intestines:
www.biorxiv.org/content/10.1...

We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism.
www.nature.com/articles/s41...

Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibition CDK4/6 inhibitors (CDK4/6i) arrest the cell cycle in G1 leading to cellular overgrowth and p53-dependent senescence. They are used to treat metastatic HR+/HER2-breast cancer, but resistance is common,...

Check out our latest work on cell cycle inhibitors, which has implications for how cancer cells could become resistant to these drugs
#senescence #cellcycle #cancer 🧪

www.biorxiv.org/content/10.1...

Great article that make some very important points

Adopting a post-publication rating system that is fair and transparent could be transformational for preprints

Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibition CDK4/6 inhibitors (CDK4/6i) arrest the cell cycle in G1 leading to cellular overgrowth and p53-dependent senescence. They are used to treat metastatic HR+/HER2- breast cancer, but resistance is common...

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size (due to defects in cohesion and the mitotic checkpoint). Great work by fab PhD student Aanchal Pareri 👏🧪

www.biorxiv.org/content/10.1...

Research Assistant in Stem Cell aging Do you want to contribute to top quality medical research? The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite t

🔬 ⚕️ Research Assistant position open for highly motivated enthusiast of hematopoietic stem cell aging at Karolinska Institutet in Sweden 🇸🇪 😃
Please share 🙏
We are excited for your application! 😎

ki.varbi.com/en/what:job/...

Cell cycle duration determines oncogenic transformation capacity - Nature Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lea...

This is fascinating…

www.nature.com/articles/s41...

Registration is open for our Signalling Circuits in Cancer virtual conference!

We're welcoming researchers from around the world to explore the dynamic signalling pathways that drive cancer development and progression.

Submit your abstract and register: eacr.org/conference/s...

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute Add brief description here

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

Interesting. Congrats Marin! So important to know how anti-cancer drugs actually work

bioart.niaid.nih.gov
smart.servier.com
bioicons.com
scidraw.io
openscienceart.com

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

Congratulations Adam and Team!