Elad Sharon, MD, MPH

Early hominin arrival in Southeast Asia triggered the evolution of major human malaria vectors - Scientific Reports Some species of the Leucosphyrus Group of Anopheles mosquitoes in Southeast Asia are highly anthropophilic and efficient vectors of human malaria parasites, while others primarily feed on non-human primates (NHP) and transmit NHP malaria parasites. The evolutionary history of this group, particularly the origin of anthropophily, was studied using phylogenomic analysis of 2,657 high-confidence nuclear single-copy orthologous genes and 13 mitochondrial protein coding genes from 40 individuals of 11 species. Molecular dating and ancestral state reconstruction revealed that monkey-feeding is ancestral with speciation of monkey-feeding species dating to the Pliocene within Sundaland (Malay peninsula, Borneo, Sumatra and Java) which was covered in tropical rain forests during this period. Although less parsimonious alternatives cannot be excluded, molecular dating, ancestral state reconstruction and reticulation analysis indicated that anthropophily most likely evolved once, involving adaptive introgression, in the early Pleistocene in Sundaland, giving rise to multiple descendent anthropophilic species. Such early origination of anthropophily must necessarily have been in response to the arrival of early hominins (Homo erectus) rather than anatomically modern humans, likely associated with loss and fragmentation of rainforests during the early Pleistocene. The early origination of anthropophily also provides independent non-archaeological evidence supporting the limited fossil record of early hominin colonization in Southeast Asia around 1.8 Mya.

The preference of some mosquitoes in the Leucosphyrus Group of Anopheles mosquitoes for feeding on humans may have evolved in response to the arrival of early hominins in Southeast Asia ~1.8 million years ago. The findings are published in Scientific Reports. 🧪 #evobio

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus, suggesting EBV reactivation may drive pathogenesis in these patients.

The findings of a study in Nature Immunology shed vital insight into the role of CD8+ T cells in multiple sclerosis and support an important role of Epstein–Barr virus in MS immunopathology. #Immunosky #medsky 🧪

Elad Sharon: For the Time Being, We Can Breathe a Sigh of Relief on NIH and⁦ NCI⁩ Funding - OncoDaily Elad Sharon: For the Time Being, We Can Breathe a Sigh of Relief on NIH and⁦ NCI⁩ Funding / cancer, Elad Sharon, NCI, NIH, Norman Sharpless, OncoDaily, Oncology

For the Time Being, We Can Breathe a Sigh of Relief on NIH and⁦ NCI⁩ Funding - Elad Sharon

@eladsharonmd.bsky.social

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#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #NIH #NCI

The heelbone of Procoptodon goliah, the largest-known kangaroo species. Credit: Pat Holroyd, UCMP

Giant ancestors of modern-day kangaroos — which previous research has estimated could weigh up to 250 kilograms — may have been able to hop in short bursts, according to research in Scientific Reports. go.nature.com/49OWsJX #evosky 🧪

Hematology twins! @mazietsangmd.bsky.social #ASH25 #fASHion cc @ash.hematology.org

Sabine Allam, MD, reports on results from the PROMISE Study, which screened ~30,000 individuals for monoclonal gammopathies. #ASH25

Watching the opening session for the #FriendsOfCancerResearch Annual Meeting! First up: seamless trial designs for rare cancer drug development! You can watch live and online: secure-web.cisco.com/1-aSs6clrewX...

Excited to be speaking on November 4th Friends of Cancer Research annual meeting (#FriendsAM25)! I will be speaking on #ContributionOfEffect (#COE) You can still register online: secure-web.cisco.com/1-aSs6clrewX...

Our 2025 ACI series concluded with sessions at ACR Convergence (Oct. 23) and APSHO's JADPRO (Oct. 27). Thank you everyone who made this series a roaring success! Missed a program? Access enduring materials: https://www.sitcancer.org/edu/aci

Jeffrey Sparks MD MMSc, Elad Sharon, MD, MPH

Diphtheria, a Once Vanquished Killer of Children, Is Resurgent

Measles is back

Whooping cough is back

Now, diphtheria is staging a return with large outbreaks now in Somalia, Sudan, Yemen and Chad — countries with civil wars or large populations of refugees where vaccination coverage is low...

www.nytimes.com/2025/10/27/h... @stephanienolen.bsky.social

Vivek Subbiah: ESMO Presidential Dinner is Kicking Off in Berlin - OncoDaily Vivek Subbiah: ESMO Presidential Dinner is Kicking Off in Berlin / cancer, ESMO, ESMO 2025, ESMO 2025 Congress, ESMO Presidential Dinner, ESMO2025, ESMO25,

ESMO Presidential Dinner is Kicking Off in Berlin - Vivek Subbiah

@viveksubbiah.bsky.social @myesmo.bsky.social

oncodaily.com/voices/vivek...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESMO #ESMO25 #ESMO2025

@ptarantinomd.bsky.social explores safety optimization of the next frontier of antibody-drug conjugate development. #ESMO25

Lung Cancer Advances at ESMO25 with Stephen V Liu - OncoDaily Lung Cancer Advances at ESMO25 with Stephen V Liu / cancer, Corinne Faivre-Finn, ESMO 2025, ESMO 2025 Congress, ESMO2025, ESMO25, Headlines, Martin Reck,

Lung Cancer Advances at ESMO25 with Stephen V Liu

@stephenvliu.bsky.social @myesmo.bsky.social

oncodaily.com/not-to-miss/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESMO #ESMO25 #ESMO2025

Dr. @pashtoonkasi discussed precision therapy in GI cancer, young CRC is mostly rectal and left-sided, high Her2 in gall bladder cancer, RAS testing on tissue often isn’t back in 2 weeks, liquid biopsy picks up heterogeneity, fusions, resistance mechs, at 2025 @WIN_Consortium Symposium.

NRG-LU005 Trial QOL Results at ASTRO 67th Annual Meeting At ASTRO 67, the NRG-LU005 trial reported improved long-term quality of life with atezolizumab and twice-daily radiotherapy in limited-stage SCLC.

NRG-LU005 Trial at the ASTRO 67th Annual Meeting: Atezolizumab and BID Radiotherapy in Limited-Stage SCLC

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #NRG-LU005 #ASTRO25 #SCLC

Elizabeth Mittendorf Named Chief of Multi-Disciplinary Oncology at Dana-Farber and Chief of Breast Surgery at BIDMC - OncoDaily Elizabeth Mittendorf Named Chief of Multi-Disciplinary Oncology at Dana-Farber and Chief of Breast Surgery at BIDMC / BIDMC, cancer, Dana-Farber’s Breast

Elizabeth Mittendorf Named Chief of Multi-Disciplinary Oncology at Dana-Farber and Chief of Breast Surgery at BIDMC

@danafarbernews.bsky.social @danafarber.bsky.social @bidmc-cancercenter.bsky.social

oncodaily.com/career/eliza...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedOnc #MedNews

Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...

What an amazing assay.

DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...

This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.

Obesity, diabetes, and inflammation: Pathophysiology and clinical implications Obesity and its related disorders, including type 2 diabetes and liver, kidney, and cardiovascular diseases, are now recognized as chronic inflammator…

Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field www.sciencedirect.com/science/arti...?

The Paris Summit of Synthetic Biology Centers, organized by @riceuniversity.bsky.social brought together global leaders of SynBio centers, biofoundries, and consortia to work out how to combine forces, grow expertise, fund discovery, and ensure ethical progress.
A productive 2 days in Paris!

Olfactory Dysfunction After SARS-CoV-2 This cohort study examines the presence, severity, and patterns of olfactory dysfunction in US adults with and without prior SARS-CoV-2 infection.

Olfactory dysfunction is common following SARS-CoV-2 infection, and can be detected on testing even in some who are unaware of having it/ don't report it (occult hyposmia)

(US RECOVER study sample)

#LongCovid

jamanetwork.com/journals/jam...

Elizabeth McKenna: Early Pancreatic Cancer Detection Improved with cfDNA Model-CD-AACR - OncoDaily Elizabeth McKenna: Early Pancreatic Cancer Detection Improved with cfDNA Model-CD-AACR / CD-AACR, Chuntao Gao, Dongqin Zhu, Elizabeth McKenna, Fenglin Zang,

Early Pancreatic Cancer Detection Improved with cfDNA Model-CD-AACR - Elizabeth McKenna

@elizsmckenna.bsky.social

oncodaily.com/voices/377561

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #PancreaticCancer

Join us in downtown Washington, DC next Saturday October 4th for the DC Lung Cancer Conference, an IASLC endorsed, 1-day CME meeting covering updates in lung cancer, featuring 58 thoughtful & dynamic faculty members. #DCLung25

Register today at medstarhealth.org/dclung25

Vivek Subbiah: Honored to Join Global Colleagues and Deliver the Message at the UN for The Last Mile Series - OncoDaily Vivek Subbiah: Honored to Join Global Colleagues and Deliver the Message at the UN for The Last Mile Series / cancer, International Cancer Patient Coalition,

Honored to Join Global Colleagues and Deliver the Message at the UN for The Last Mile Series - Vivek Subbiah

@viveksubbiah.bsky.social

oncodaily.com/voices/vivek...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews

Thanks to all who made our Chicago group meeting a success! It went by too quickly, but it’s always refreshing to see our #SWOGonc community in person. We're grateful for our donors 🙏 And for those who picked up some new @swog.org swag, we’re excited to see where you’ll be spotted wearing it!

Narjust Florez: A Meaningful Week of Science at the WCLC25 - OncoDaily Narjust Florez: A Meaningful Week of Science at the WCLC25 / cancer, Lung cancer, Narjust Florez, OncoDaily, Oncology, WCLC25

A Meaningful Week of Science at the WCLC25 - Narjust Florez

@narjustflorezmd.bsky.social

oncodaily.com/voices/narju...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #WCLC25

Robin Zon Has Been Promoted to Chair of ASCO Society Board - OncoDaily Robin Zon Has Been Promoted to Chair of ASCO Society Board / American Society of Clinical Oncology, ASCO, cancer, OncoDaily, Oncology, Robin Zon

Robin Zon Has Been Promoted to Chair of ASCO Society Board

@ascocancer.bsky.social

oncodaily.com/career/robin...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ASCO

‘One jab will do the job’: Pakistan begins rollout of HPV vaccine to millions of girls Despite vaccination hesitancy, the end may be in sight for cervical cancer, which kills 64% of women with the disease

‘One jab will do the job’: Pakistan begins rollout of HPV vaccine to millions of girls

Partitioning obesity by genomics, proteomics and health outcomes from >450,000 UK Biobank
@naturemedicine.bsky.social

—A protective subtype vs cardiometabolic diseases (GRS BFP) and
—A risk subtype for these diseases (GRS uncoupling)
GRS-genomic risk score
nature.com/articles/s41...

A randomized controlled trial on the effect of administrative burden and information costs on social inequalities in early childcare access in France Nature Human Behaviour - This RCT finds that providing information and support to target cognitive and behavioural barriers eliminates early childcare application gaps for low-income and immigrant...

1/ Thrilled to share that my main PhD article has just been published in Nature Human Behaviour! 🎉

👉 “A randomised controlled trial on the effect of administrative burden and information costs on social inequalities in early childcare access in France” rdcu.be/eFAEA

Caring Beyond the Diagnosis: UICC's Global Impact on Cancer Support - OncoDaily Caring Beyond the Diagnosis: UICC's Global Impact on Cancer Support / cancer, CANSA The Cancer Association of South Africa, OncoDaily, Oncology, UICC, UICC

Caring Beyond the Diagnosis: UICC’s Global Impact on Cancer Support

@uiccofficial.bsky.social

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#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #UICC