Univ. of Pennsylvania Department of Cancer Biology

Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies ft. Yuqiao Liu & Junwei Shi (@penncbio.bsky.social) @aacrjournals.bsky.social aacrjournals.org/cancerdiscov...

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

📣 New preprint 📣

We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.

Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Amy Gladstein in the Feldser lab defends her thesis tomorrow!

Congratulations to @LilingWanLab (@penncbio.bsky.social/ @penncancer.bsky.social), recipient of a 2025 @PershingSqFdn Sohn Cancer Prize! tinyurl.com/zse5mbj4

ft. Siera Tomishima, Dale Kim, @YohanizOrtega, Paula Oliver (@pennpathlabmed.bsky.social), Robert Bowman (@penncbio.bsky.social), Nadia Porter, Ipsita Guha, @dar_darasif, Jennifer Roof, Hossein Fazelinia, Lynn Spruce & Christopher Thom (@chopresearch.bsky.social) www.jci.org/articles/vie...

Meet Donita Brady Donita Brady is an associate professor of cancer biology and an associate editor of the Journal of Biological Chemistry, who studies metalloallostery in cancer.

#TuesdayMotivation | Meet Donita Brady (@bradylabupenn.bsky.social) at @pennmedicine.bsky.social (@penncbio.bsky.social & @rtaatpennmed.bsky.social): ow.ly/2hbi50WIzuM.

Her lab investigates how copper modulates signal transduction in healthy and cancerous cells.
#CancerResearch #tumorigenesis

Congratulations to @bradylabupenn.bsky.social (@penncbio.bsky.social/ @rtaatpennmed.bsky.social), recipient of the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science! tinyurl.com/6w7n3uzx

A 1st-of-its-kind clinical trial identified risk of breast cancer recurrence & successfully treated dormant tumor cells using existing drugs ft. @angiedemichele.bsky.social (@penncancer.bsky.social) & Lewis Chodosh (@penncbio.bsky.social) tinyurl.com/mryru5ew

Congratulations to @rdrapkin8-penn.bsky.social (@PennOBGYN), recipient of a 2025 @PershingSqFdn Ovarian Cancer Challenge Grant! @Penn_OCRC @penncancer.bsky.social @BasserBRCA tinyurl.com/yjvvyr4k

The H3 K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer - PubMed Mutations in histone 3 at or near lysine 36 (H3K36) have dominantly acting oncogenic effects in multiple tumor types by limiting H3K36-directed methyltransferases. Paradoxically, we find that…

New preprint for Amy Gladstein (@amygladstein) in the @Feldserlab on: The H3 K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer pubmed.ncbi.nlm.nih.gov/40501771/

Join @BB_UPenn, @penncbio.bsky.social, @PennCDB, @CAMBUpenn, @UPennEEJust, @duboiscircle, @RTAatPennMed on Wednesday, 6/18 at 1pm for the 3rd annual #Juneteenth seminar ft'ing keynote speaker Dr. Squire Booker. Learn more➡️ tinyurl.com/kpnetx9f

#ICYMI: Nominations for the @pennmedicine.bsky.social Awards of Excellence, which recognize our faculty's exceptional achievements in mentoring, professionalism, research & clinical work, are open through Friday, 6/20! Learn more➡️ bit.ly/3yAaduR #PSOMAOE

Learn more about 2-PREVENT Breast Cancer Translational Center for Excellence led by @angiedemichele.bsky.social & @penncbio.bsky.social chair Lewis Chodosh to identify and treat dormant breast cancer to forestall recurrence.

ft. Elizabeth McDonald, @DavidMankoff2, Robert Mach (@PennRadiology), Tien-Chi Pan, @dhruvk_pant & Lewis Chodosh (@penncbio.bsky.social/ @penncancer.bsky.social) aacrjournals.org/cancerrescom...

#STATMadness voting is now open! Show your support for @pennmedicine.bsky.social's @StephenBagleyMD, @LogunMeghan, Zev Binder, @orourkedm & colleagues by voting to advance their study to the next round of competition! @PennNSG @penncancer.bsky.social @statnews.com tinyurl.com/yp2zbsce

Snapshots of acyl carrier protein shuttling in human fatty acid synthase ft. @kschultzy.bsky.social, Pedro Costa-Pinheiro, Lauren Gardner, @laura_vpinheiro, Julio Ramirez-Solis, Sarah Gardner, @WellenLab & @MarmorsteinLab @penncancer.bsky.social @BB_UPenn @Penn_CBIO www.nature.com/articles/s41...

We're excited to launch the official BlueSky account of the Department of Cancer Biology @pennmedicine.bsky.social. Stay tuned for our upcoming faculty search ad, highlights from our published research discoveries, and other departmental news! med.upenn.edu/cbio/