Animalcules

Bacteria That Can Come Back From The Dead May Have Gone To Space: "They Are Playing Hide And Seek" Extremely sturdy bacteria that only play dead may have hitched a ride on our spacecraft.

www.iflscience.com/bacteria-tha...

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How do bacteria survive phage infections? Bae et al. explore diverse #antiphage defense systems, with a special focus on the model pathogen Pseudomonas aeruginosa due to its strain diversity and genomic adaptability.
buff.ly/phnGnWL
#FEMSMicrobiolRev

Fungus on an algae plate as contaminant

@contamclub.bsky.social

A fungus on THY agar broth... secreting some yellow compound...

High-throughput conjugation reveals strain specific recombination patterns enabling precise trait mapping in Escherichia coli Author summary Escherichia coli demonstrates a remarkable ability to adapt to diverse environments. This adaptability is in part connected to its ability to recombine incoming DNA in its chromosome, a...

journals.plos.org/plosgenetics...

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New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

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#MicroSky: The protein PsyOmp38 inhibits and disrupts S. epidermidis biofilms. When combined with vancomycin, it enhances antibiotic efficacy by lowering MBEC values. PDMS coated with PsyOmp38 prevents biofilm formation, highlighting its promise for antibiofilm materials. doi.org/10.1111/1751...

doi.org/10.1016/j.is...

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EASY-edit: a toolbox for high-throughput single-step custom genetic editing in bacteria Abstract. Targeted gene editing can be achieved using CRISPR–Cas9-assisted recombineering. However, high-efficiency editing requires careful optimization f

academic.oup.com/nar/article/...

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“No -canonical” cell division machinery
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Potent New Antibiotic Against Resistant Bacteria Found in Streptomyces coelicolor A potent new antibiotic intermediate from Streptomyces coelicolor is 100 times stronger than methylenomycin A against drug-resistant bacteria.

www.genengnews.com/topics/infec...

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microfabricated stamps, fresh off the printer :)

Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC Abstract. Natural chromosomal transformation (NCT) in Bacillus subtilis requires RecA and its accessory proteins including RecX and RecD2. Inactivation of

Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC url: academic.oup.com/nar/article/...

Pseudomonas aeruginosa affects Acinetobacter baumannii’s growth, gene expression and antibiotic resistance in in vitro co-culture system Pseudomonas aeruginosa and Acinetobacter baumannii are opportunistic pathogens co-isolated frequently in the same infection sites. In this study, we a…

www.sciencedirect.com/science/arti...

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Bacterial TIR-based immune systems sense phage capsids to initiate defense - Nature Microbiology After sensing capsids, the Thoeris antiphage defense system triggers a cascade that leads to NAD+ cleavage and cell arrest, which are dynamics that are mirrored in some mammalian immune pathways.

www.nature.com/articles/s41...

#phagesky #phage defence system Thoeris

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Did you know most 'complete' Streptomyces genomes are missing their telomeres?

Thanks to David and Tues hard work, we now have a new tool to recover them!

A pleasure to be part of a team. :)

🦠🧪💻 #microsky

New retron systems from environmental bacteria identify triggers of anti-phage defense and expand tools for genome editing Bacteria rely on retrons for phage defense, yet most known systems come from clinical or lab strains. This study identifies new and diverse retrons from environmental bacteria, uncovering their phage defense mechanisms and applying them as genome editing tools.

New retron systems from environmental bacteria identify triggers of anti-phage defense and expand tools for genome editing | PLOS Biology https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003042

Impeding pathways of intrinsic resistance in Escherichia coli confers antibiotic sensitization and resistance proofing Intrinsic resistance pathways in E. coli can be exploited to enhance antibiotic sensitivity and limit resistance evolution. This study shows that genetic inhibition of efflux pumps and cell envelope b...

journals.plos.org/plosbiology/...

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fans of NAPs take note 👇

what Spurio 𝘦𝘵 𝘢𝘭. (1992) saw as complete condensation of the 𝘌. 𝘤𝘰𝘭𝘪 nucleoid due to H-NS overproduction (f), can now be traced down to individual loops by Way 𝘦𝘵 𝘢𝘭. (2025).

#MicroSky @meyerroc.bsky.social @pdersch.bsky.social y.social @phoeberice.bsky.social

SmallBARNA 2026: a kingdom-wide bacterial sRNA resource Abstract. Bacterial small RNA are important context-sensitive regulators of gene expression, especially in highly pathogenic bacteria, often controlling vi

academic.oup.com/nar/advance-...

#microsky a database of bacterial small RNA experimental data

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Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.

Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle

#bacteria #microbiology

Emergence of population-level feedback control by transposon-plasmid coevolution
doi.org/10.1101/2025...

E. coli bacteriophage N15 suppresses Mre11-Rad50-mediated end degradation of its linear genome via a telomere-resolution-independent function of its telomere resolvase TelN
#RefereedPreprint c/o @reviewcommons.org by @gruberlab.bsky.social
www.embopress.org/doi/full/10....

Paralogs with distinct phase behaviors broaden the in vivo stress response range of condensates Paralogs are widespread, but their physiological roles are often masked by redundancy. H-NS, a nucleoid-associated protein in Gram-negative bacteria, typically coexists with paralogs such as StpA, who...

Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...

Scientists 'reawaken' ancient microbes from permafrost — and discover they start churning out CO2 soon after Researchers incubated permafrost samples from Alaska at different temperatures and found that microbes from the last ice age can reactivate and resume breaking down carbon.

www.livescience.com/planet-earth...
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