Victor Javier

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Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours 🧪 #PancreaticCancer www.biorxiv.org/content/10.6...

AI predicted TCR-pMHC structures differentiate immune interactions 🧪🧬🖥️ www.biorxiv.org/content/10.6...

Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications #PancreaticCancer 🧪 idp.nature.com/authorize?re...

UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in #PancreaticCancer 🧪 idp.nature.com/authorize?re...

A real pleasure to host Alejo Efeyan today. He shared fascinating insights on how nutrient sensing and Rag GTPases tune mTORC1, shaping both cancer progression and aging. Grateful for his clarity and inspiring science. 🧪 @ufvmadrid.bsky.social @cniostopcancer.bsky.social

Frontiers | AC005034.3/hsa-miR-126-5p/EIF3H axis: bioinformatics analysis, expression validation, and association with prognosis and immunosuppressive microenvironment in pancreatic adenocarcinoma BackgroundPancreatic adenocarcinoma (PAAD) ranks among the most lethal human solid tumors, distinguished by its swift progression and limited effective treat...

AC005034.3/hsa-miR-126-5p/EIF3H axis: bioinformatics analysis, expression validation, and association with prognosis and immunosuppressive microenvironment in pancreatic adenocarcinoma #PancreaticCancer 🧪 www.frontiersin.org/journals/cel...

Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells #PancreaticCancer 🧪 idp.nature.com/authorize?re...

UCell and pyUCell: single-cell gene signature scoring for R and python AbstractSummary. Gene signature scoring provides a simple yet powerful approach for quantifying biological signals within single-cell omics datasets. UCell

UCell (v2) and pyUCell: single-cell gene signature scoring for R and Python.
We discuss updates and key parameters
academic.oup.com/bioinformati...

MUC15 Loss Promotes Perineural Invasion in Pancreatic Cancer by Activating the IGF1R/STAT3/NGF Pathway Perineural invasion (PNI) is a critical yet poorly understood feature that significantly influences the prognosis of pancreatic ductal adenocarcinoma …

MUC15 Loss Promotes Perineural Invasion in #PancreaticCancer by Activating the IGF1R/STAT3/NGF Pathway 🧪 www.sciencedirect.com/science/arti...

Global dissemination of FC-ϵ RI and p53 signalling perturbation contribute to Dasatinib resistance in #PancreaticCancer Cell-lines 🧪 www.biorxiv.org/content/10.6...

MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma Immune checkpoint inhibitors show insufficient efficacy against pancreatic ductal adenocarcinoma (PDAC). The tumor microenvironment (TME) has a remark…

MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma www.sciencedirect.com/science/arti... #PancreaticCancer 🧪

α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer - Cell Death & Disease Cell Death & Disease - α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer

α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to #PancreaticCancer idp.nature.com/authorize?re...

Nallo: a Nextflow pipeline for comprehensive human long-read genome analysis AbstractMotivation. Long-read sequencing (LRS) is increasingly used for human medical research and clinical diagnostics, due to its capacity to generate co

Nallo: a Nextflow pipeline for comprehensive human long-read genome analysis 🧬🖥️ academic.oup.com/bioinformati...

FEBS Press This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early-stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mi...

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma febs.onlinelibrary.wiley.com/doi/10.1002/... 🧪 #PancreaticCancer

Cancer-associated fibroblasts promote immune evasion in pancreatic cancer via miR-181b-5p/STING/LGALS1 pathway Pancreatic cancer remains one of the deadliest malignancies, characterized as a natural “immune desert”. Despite the remarkable advances of cancer imm…

Cancer-associated fibroblasts promote immune evasion in #PancreaticCancer via miR-181b-5p/STING/LGALS1 pathway www.sciencedirect.com/science/arti...

Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a 5-year survival rate of just 13%. While the development and …

Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in #PancreaticCancer 🧪 www.sciencedirect.com/science/arti...

Risk-stratified surveillance for individuals in the UK at high risk of developing pancreatic cancer: Outcomes from the European Registry of Hereditary Pancreatic Diseases (EUROPAC). Surveillance of individuals with a familial predisposition to pancreatic ductal adenocarcinoma (PDAC) is likely to increase overall survival. Our obje…

Risk-stratified surveillance for individuals in the UK at high risk of developing #PancreaticCancer: Outcomes from the European Registry of Hereditary Pancreatic Diseases (EUROPAC). 🧪 www.sciencedirect.com/science/arti...

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs. Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress-response genes like ATF4, rendering cells resistant to chemotherapy and apopto...

Decoding the Integrated Stress Response of #PancreaticCancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs. 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...

Efficacy and Safety of Combination Therapy With Immune Checkpoint Inhibitors and Chemotherapy With Gemcitabine and Nab‐Paclitaxel in Pancreatic Cancer: A Systematic Review Background Pancreatic cancer (PC) is a lethal malignancy with a 5-year survival rate of 13% as the 7th leading cause of cancer-related death worldwide. Most patients are ineligible for resection at ...

Efficacy and Safety of Combination Therapy With Immune Checkpoint Inhibitors and Chemotherapy With Gemcitabine and Nab‐Paclitaxel in #PancreaticCancer: A Systematic Review 🧪 onlinelibrary.wiley.com/doi/10.1002/...

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer This study integrates multi-omics to reveal the critical role of UBE2T in driving malignancy and stromal co-evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positiv...

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in #PancreaticCancer 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma www.sciencedirect.com/science/arti...

Quick #CRISPR question for the #Bioinformatics and #MolecularBio community:

Has anyone done a direct comparison between CRISPRi (dCas9-KRAB) vs. CRISPRko regarding off-target effects?

#AcademicSky

Congrats!

tensorOmics: Data integration for longitudinal omics data using tensor factorisation 🧬🖥️ www.biorxiv.org/content/10.6...

Viscoelasticity drives EMT in pancreatic intraepithelial neoplasia #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Diet-induced macrophage-driven inflammation fuels pancreatic plasticity and aggressiveness #PancreaticCacner 🧪 www.biorxiv.org/content/10.6...

Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic #PancreaticCancer Model 🧪 www.biorxiv.org/content/10.6...

Network-based integration of gene expression and DNA methylation identifies prognostic biomarkers for early-stage #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...