Biointerphases

Ecomechanics of mollusks’ radula Mollusks, and their particularly diverse class Gastropoda, owe much of their ecological success due to the evolution of their radula—a specialized feeding appar

Wencke Krings leads a review exploring how diet shapes the form & mechanics of mollusks' radular teeth through echomechanics. Categorizing them like human tools, this aims to inspire engineering innovations & explore responses to environmental changes. doi.org/10.1116/6.00...

Volume 20 Issue 6 | Biointerphases | AIP Publishing Biointerphases is an interdisciplinary peer-reviewed journal featuring all aspects of quantitative soft matter interfaces: chemistry physics engineering theory and modeling.

⏰The latest issue of Biointerphases has dropped! 👇

Check it out to read articles from @utaustin.bsky.social, University of Wollongong, @uwbioe.bsky.social, @tudresden.bsky.social, and others.

pubs.aip.org/avs/bip/issu...

Hydrolytic and enzymatic degradation of linear segmented polyurethane block copolymers studied by ToF-SIMS and atomic force microscopy Hydrolytic and enzymatic degradation of linear segmented polyurethanes with differing compositions were studied by atomic force microscopy and time-of-flight se

Authors from @uwbioe.bsky.social use AFM & Tof-SIMS to study hydrolytic & enzymatic degradation of polyurethanes, showing polymer surface roughness in aqueous conditions is affected by bulk composition. Incorporating collagenase-cleavable peptides accelerated degradation.
doi.org/10.1116/6.00...

The 10th Chinese National Conference on Secondary Ion Mass Spectrometry was held in Xi'an, China this past October. Biointerphases was pleased to present poster awards to these early-career… | Bio... The 10th Chinese National Conference on Secondary Ion Mass Spectrometry was held in Xi'an, China this past October. Biointerphases was pleased to present poster awards to these early-career researcher...

Biointerphases was pleased to present poster awards at the 10th Chinese National Conference on Secondary Ion Mass Spectrometry, held in Xi'an, China this past October. Congratulations to the winners! 👍
www.linkedin.com/posts/bioint...

Enhanced osteogenic activities of magnesium-containing nanowire modified-titanium surface via macrophage immunomodulation We aimed to synthesize modified magnesium nanowire (Ti-NW-Mg) on the surface of titanium implants and to investigate its effects on bone binding by regulating m

Ti-NW-Mg modified titanium implants were synthesized & shown to improve bone formation — reducing macrophage growth & inflammation while regulating macrophage polarization. The results suggest a promising implant material for enhancing osteogenesis.
doi.org/10.1116/6.00...

Single-molecule dynamics of fibrinogen and bovine serum albumin adsorption on silica nanoparticle coatings observed using high-speed atomic force microscopy High-speed atomic force microscopy (HS-AFM) was used to directly visualize the single-molecule adsorption dynamics of fibrinogen (FG) and bovine serum albumin (

High-speed atomic force microscopy enabled direct visualization of single-molecule adsorption dynamics of bovine serum albumin and fibrinogen on silica nanoparticle coatings, revealing distinct, protein-specific and dynamic interfacial mechanisms.
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Soft probe particle tracking microrheology using membraneless organelles to study viscoelasticity of nucleolar subcompartments Tracking cellular viscoelastic properties is critical for identifying early signs of pathogenesis. We introduce soft probe particle tracking microrheology (S-PT

Soft probe particle tracking microrheology (S-PTM) tracks the motion of cell subcompartments to measure mechanical properties in the surrounding environment. In the nucleolus, S-PTM revealed distinct layers with different properties. doi.org/10.1116/6.00... @utbiomedical.bsky.social

On our latest cover, we feature research from @iitbengaluru.bsky.social studying the role of the proteoglycan Decorin in regulating ovarian cancer progression. Glycosaminoglycan chains in Decorin are crucial to its role fighting invasive cells. 💪
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Promiscuous binding peptides—Computational screening reveals higher-affinity peptides for gold binding beyond phage display selections Peptides that selectively bind to inorganic surfaces play a crucial role in nanobiotechnology, biomaterials, and biosensing applications. While phage display ha

In evaluating peptide binding against an Au(111) surface, this group from IIT Gandhinagar used molecular dynamics simulations to compare solid-binding peptides for biosensing, while showing the limitations of phage display techniques.
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Development and optimization of decellularized seaweed scaffolds for tissue engineering In this study, the marine red seaweed Devaleraea mollis (commonly known as Pacific dulse) was investigated as a green, sustainable, and animal-free tissue scaff

Cellulose scaffolds made from decellularized pacific dulse seaweed have inflammatory/antimicrobial properties & compatibility with cardiac cells, showing the promise of seaweed-derived cellulose in tissue engineering & other biomedical applications.
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Dissecting the role of substrate folding in enzymatic digestion The efficiency of enzymatic proteolysis is often attributed to the properties of the enzyme itself, with the substrate typically viewed as a passive participant

Using urea as a denaturing agent, authors from IIT Kanpur show that the proteolysis rate of human serum albumin (HSA) with papain is dependent on conformational state, with HSA digestion accelerating at unfolded states.
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Femtosecond laser-textured copper surface for reducing initial copper ion burst release in intrauterine devices Copper intrauterine devices (Cu-IUDs) are widely used for long-term contraception; yet, the burst release of Cu2+ during early implantation often induces advers

To temper adverse uterine side effects from copper IUD implantation, researchers created a biomimetic microstructure inspired by golden pothos leaves using femtosecond laser texturing. This could effectively mitigate copper-ion burst release. doi.org/10.1116/6.00...

Our latest cover features an article from @uarkansas.bsky.social on the relationship between bacterial motility and soil microstructures and how it impacts nutrient cycling, bioremediation, and overall soil health.
Article: doi.org/10.1116/6.00...
Issue: pubs.aip.org/avs/bip/issu...

Emerging biomedical applications of herbal extracts-based biomaterials Bioactive herbal extracts have garnered significant attention due to their multitarget regulation and low toxicity, yet their clinical applications are limited

This review from Zhejiang University systematically summarizes the pharmacological properties of terpenoids, alkaloids, flavonoids, polysaccharides & other components & explores integration with biomaterials such as nanoparticle delivery systems, microneedles, & hydrogels.
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Surface potential modulates fibronectin adsorption and molecular interaction on graphene-based materials Protein interactions on graphene-based materials (GBMs) are predominantly governed by interphase surface properties such as surface chemistry and roughness; how

Researchers from @iitdelhi.bsky.social use two forms of graphene to demonstrate how material surface potential affects protein behavior.
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Featured on our most recent cover, researchers from Dalian University of Technology used bioinformatics & machine learning approaches to reveal the involvement of necroptosis-related genes and altered immune infiltration in hepatoblastoma pathogenesis.
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Bacterial motility in aqueous micro-environment with natural soil particles Bacterial motility is essential for navigating heterogeneous environments like soil, where it plays a key role in nutrient cycling, bioremediation, and overall

How do E. coli & other motile bacteria move through wet soil? This study out of @uarkansas.bsky.social explores how soil particle structures affect bacterial behavior—key for understanding nutrient cycling, soil health, & ecosystem dynamics. doi.org/10.1116/6.00...

In vitro assessment of polyethylene glycol-coated iron oxide nanoparticles integrating luteinizing hormone releasing-hormone targeted magnetic hyperthermia and doxorubicin for lung and breast cancer c... Magnetic nanoparticle-based targeted hyperthermia, combined with chemotherapy, is a promising approach for cancer treatment. In this study, a targeted magnetic

Researchers from Thapar Institute of Engineering & Technology developed a targeted magnetic drug delivery system using PEG-coated iron oxide nanoparticles loaded with doxorubicin & tagged with luteinizing hormone-releasing hormone (Triptorelin) for lung & breast cancer cells.
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Accounting for 10-25% of facial fractures, orbital fractures cause complications which are exacerbated when the fracture is not repaired properly. This review covers the pros & cons of commonly-used implants & explores the future of implant development. doi.org/10.1116/6.00...

Biointerfaces in China | Biointerphases Special Topic Collections Email from AVS   Call for Research Articles Special Topic Collection: Biointerfaces in China Manuscript Deadline: August 30, 2025 Biointerphases is soliciting articles for publication in a Special To

🚨Calling all researchers in China!🚨

This collection focuses on the current progress of biointerface science in China - and we want YOUR perspective! Submit until August 30, 2025.

tinyurl.com/4yux6jrj

🚨New cover just dropped!🚨

In the featured study, authors at @KyushuUniv_EN explore enhancing epithelial tissue sealing of dental implants made from materials like Ti–6Al–4V, which exhibits superior tensile strength & hardness compared to pure titanium.

doi.org/10.1116/6.00...

Early sum frequency generation vibrational spectroscopic studies on peptides and proteins at interfaces This paper summarizes the early research results on studying proteins and peptides at interfaces using sum frequency generation (SFG) vibrational spectroscopy.

This Tutorial from @umich.edu reviews early & future studies on peptides/proteins at interfaces, highlighting the evolution of #sumfrequencygeneration into a powerful tool for probing interfacial structures, orientation, & interactions.
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Special Topic Collection: Tutorials in Sum-Frequency Generation Spectroscopy - AIP Publishing LLC

Submit your SFG tutorial to our collection to contribute to this resource for anyone new to SFG spectroscopy!

tinyurl.com/5xnpzub4

Development of electronic sum frequency generation spectrophotometer to assess the buried interfaces The interfacial region between two bulk media in organic semiconductor based devices, such as organic field-effect transistors (OFETs), organic light-emitting d

This tutorial describes an electronic SFG experimental setup to probe electronic states present at interfaces, and provides instrumental and experimental details for those wishing to begin or optimize an ESFG setup for themselves.
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The Goldilocks Principle in Biomaterials and Biointerfaces - AIP Publishing LLC

Too reactive, not reactive enough, or just right? Precisely engineered surfaces can ensure proper cell adhesion & function. Submit your research concerning phenomena such as this to our collection on The Goldilocks Principle!
tinyurl.com/4kn5b54a

Applications of multivariate analysis and unsupervised machine learning to ToF-SIMS images of organic, bioorganic, and biological systems Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging offers a powerful, label-free method for exploring organic, bioorganic, and biological systems

ToF-SIMS is capable of very high spatial resolution while producing enormous amounts of information about surface composition. This review from @latrobeuni.bsky.social explores algorithms that have been applied to ToF-SIMS images over the past few decades.
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Phenomenological investigation of organic modified cements as biocompatible substrates interfacing model marine organisms Organic modification can generally endow inorganic materials with novel and promotional characteristics to fit into new functionalities. In this paper, new ceme

Surface-modified cement with polyacrylamide (PAM) or PAM/chitosan enhances biofilm & #coralgrowth while maintaining strength, showing promise for eco-friendly #coastalengineering. Long-term durability and biocompatibility tests will be needed.
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Drug-eluting contact lenses: Progress, challenges, and prospects Topical ophthalmic solutions (eye drops) are becoming increasingly popular in treating and preventing ocular diseases for their safety, noninvasiveness, and eas

Our most-read review article, this work discusses advances in drug-eluting contact lenses: preparation, drug-loading & ocular penetration strategies, release mechanisms, drug delivery & penetration detection, safety, & biocompatibility validation methods.
doi.org/10.1116/6.00...

Enhancing epithelial tissue sealing of titanium alloy implants through CaCl2-based hydrothermal treatment The long-term stability of dental implants is significantly influenced by their resistance to foreign factors in the peri-implant epithelium (PIE). Despite this

Researchers from Kyushu University show how hydrothermal CaCl₂ treatment of Ti64 #implants boosts laminin-332 & cell attachment, enhancing soft tissue sealing & implant stability without changing surface topography. @avs-members.bsky.social
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Brooke Farrugia Appointed BIP Associate Editor Email from AVS   Dr. Brooke Farrugia Appointed New Biointerphases Associate Editor Dr. Brooke Farrugia is an Associate Professor in the Department of Biomedical Engineering at the University of Melbo

Welcome to our new Associate Editor, @brookefarrugia.bsky.social from University of Melbourne! We look forward to working with her as she continues to contribute to BIP and @avs-members.bsky.social.
tinyurl.com/cmaa4byn