Biointerphases

Our latest cover features an article from @uarkansas.bsky.social on the relationship between bacterial motility and soil microstructures and how it impacts nutrient cycling, bioremediation, and overall soil health.
Article: doi.org/10.1116/6.00...
Issue: pubs.aip.org/avs/bip/issu...

Emerging biomedical applications of herbal extracts-based biomaterials Bioactive herbal extracts have garnered significant attention due to their multitarget regulation and low toxicity, yet their clinical applications are limited

This review from Zhejiang University systematically summarizes the pharmacological properties of terpenoids, alkaloids, flavonoids, polysaccharides & other components & explores integration with biomaterials such as nanoparticle delivery systems, microneedles, & hydrogels.
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Surface potential modulates fibronectin adsorption and molecular interaction on graphene-based materials Protein interactions on graphene-based materials (GBMs) are predominantly governed by interphase surface properties such as surface chemistry and roughness; how

Researchers from @iitdelhi.bsky.social use two forms of graphene to demonstrate how material surface potential affects protein behavior.
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Featured on our most recent cover, researchers from Dalian University of Technology used bioinformatics & machine learning approaches to reveal the involvement of necroptosis-related genes and altered immune infiltration in hepatoblastoma pathogenesis.
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Bacterial motility in aqueous micro-environment with natural soil particles Bacterial motility is essential for navigating heterogeneous environments like soil, where it plays a key role in nutrient cycling, bioremediation, and overall

How do E. coli & other motile bacteria move through wet soil? This study out of @uarkansas.bsky.social explores how soil particle structures affect bacterial behavior—key for understanding nutrient cycling, soil health, & ecosystem dynamics. doi.org/10.1116/6.00...

In vitro assessment of polyethylene glycol-coated iron oxide nanoparticles integrating luteinizing hormone releasing-hormone targeted magnetic hyperthermia and doxorubicin for lung and breast cancer c... Magnetic nanoparticle-based targeted hyperthermia, combined with chemotherapy, is a promising approach for cancer treatment. In this study, a targeted magnetic

Researchers from Thapar Institute of Engineering & Technology developed a targeted magnetic drug delivery system using PEG-coated iron oxide nanoparticles loaded with doxorubicin & tagged with luteinizing hormone-releasing hormone (Triptorelin) for lung & breast cancer cells.
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Accounting for 10-25% of facial fractures, orbital fractures cause complications which are exacerbated when the fracture is not repaired properly. This review covers the pros & cons of commonly-used implants & explores the future of implant development. doi.org/10.1116/6.00...

Biointerfaces in China | Biointerphases Special Topic Collections Email from AVS   Call for Research Articles Special Topic Collection: Biointerfaces in China Manuscript Deadline: August 30, 2025 Biointerphases is soliciting articles for publication in a Special To

🚨Calling all researchers in China!🚨

This collection focuses on the current progress of biointerface science in China - and we want YOUR perspective! Submit until August 30, 2025.

tinyurl.com/4yux6jrj

🚨New cover just dropped!🚨

In the featured study, authors at @KyushuUniv_EN explore enhancing epithelial tissue sealing of dental implants made from materials like Ti–6Al–4V, which exhibits superior tensile strength & hardness compared to pure titanium.

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Early sum frequency generation vibrational spectroscopic studies on peptides and proteins at interfaces This paper summarizes the early research results on studying proteins and peptides at interfaces using sum frequency generation (SFG) vibrational spectroscopy.

This Tutorial from @umich.edu reviews early & future studies on peptides/proteins at interfaces, highlighting the evolution of #sumfrequencygeneration into a powerful tool for probing interfacial structures, orientation, & interactions.
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Special Topic Collection: Tutorials in Sum-Frequency Generation Spectroscopy - AIP Publishing LLC

Submit your SFG tutorial to our collection to contribute to this resource for anyone new to SFG spectroscopy!

tinyurl.com/5xnpzub4

Development of electronic sum frequency generation spectrophotometer to assess the buried interfaces The interfacial region between two bulk media in organic semiconductor based devices, such as organic field-effect transistors (OFETs), organic light-emitting d

This tutorial describes an electronic SFG experimental setup to probe electronic states present at interfaces, and provides instrumental and experimental details for those wishing to begin or optimize an ESFG setup for themselves.
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The Goldilocks Principle in Biomaterials and Biointerfaces - AIP Publishing LLC

Too reactive, not reactive enough, or just right? Precisely engineered surfaces can ensure proper cell adhesion & function. Submit your research concerning phenomena such as this to our collection on The Goldilocks Principle!
tinyurl.com/4kn5b54a

Applications of multivariate analysis and unsupervised machine learning to ToF-SIMS images of organic, bioorganic, and biological systems Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging offers a powerful, label-free method for exploring organic, bioorganic, and biological systems

ToF-SIMS is capable of very high spatial resolution while producing enormous amounts of information about surface composition. This review from @latrobeuni.bsky.social explores algorithms that have been applied to ToF-SIMS images over the past few decades.
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Phenomenological investigation of organic modified cements as biocompatible substrates interfacing model marine organisms Organic modification can generally endow inorganic materials with novel and promotional characteristics to fit into new functionalities. In this paper, new ceme

Surface-modified cement with polyacrylamide (PAM) or PAM/chitosan enhances biofilm & #coralgrowth while maintaining strength, showing promise for eco-friendly #coastalengineering. Long-term durability and biocompatibility tests will be needed.
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Drug-eluting contact lenses: Progress, challenges, and prospects Topical ophthalmic solutions (eye drops) are becoming increasingly popular in treating and preventing ocular diseases for their safety, noninvasiveness, and eas

Our most-read review article, this work discusses advances in drug-eluting contact lenses: preparation, drug-loading & ocular penetration strategies, release mechanisms, drug delivery & penetration detection, safety, & biocompatibility validation methods.
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Enhancing epithelial tissue sealing of titanium alloy implants through CaCl2-based hydrothermal treatment The long-term stability of dental implants is significantly influenced by their resistance to foreign factors in the peri-implant epithelium (PIE). Despite this

Researchers from Kyushu University show how hydrothermal CaCl₂ treatment of Ti64 #implants boosts laminin-332 & cell attachment, enhancing soft tissue sealing & implant stability without changing surface topography. @avs-members.bsky.social
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Brooke Farrugia Appointed BIP Associate Editor Email from AVS   Dr. Brooke Farrugia Appointed New Biointerphases Associate Editor Dr. Brooke Farrugia is an Associate Professor in the Department of Biomedical Engineering at the University of Melbo

Welcome to our new Associate Editor, @brookefarrugia.bsky.social from University of Melbourne! We look forward to working with her as she continues to contribute to BIP and @avs-members.bsky.social.
tinyurl.com/cmaa4byn

Enhanced bactericidal performance of textiles through compound antimicrobial agents This study aims to explore the essential functional requirements associated with controlling the proliferation of microbes in the domain of textiles used in pub

To address the proliferation of microbes in textiles used in public health areas, researchers integrated specific ratios of #antimicrobial agents (IPBC, ZPT, OIT) into nylon, finding some produce additive effects without reducing whiteness or strength.

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Sum-frequency vibrational spectroscopy, a tutorial: Applications for the study of lipid membrane structure and dynamics Planar supported lipid bilayers (PSLBs) are an ideal model for the study of lipid membrane structures and dynamics when using sum-frequency vibrational spectros

This #tutorial from authors at @utah.edu demonstrates how sum-frequency vibrational spectroscopy is used on planar supported lipid bilayers to study membrane structures & dynamics, like phospholipid orientation & flip-flop. @avs-members.bsky.social

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Clinical study on the application effect of improved polyetheretherketone cranial plate in cranioplasty This study evaluates the clinical outcomes associated with the use of an improved polyetheretherketone (PEEK) cranial plate in cranioplasty surgery. A total of

#Cranioplasty is a technique in neurosurgery that aims to repair skull defects, restore cranial structure integrity, & protect the brain. This study explores how enhanced PEEK materials impact post-op complications, patient satisfaction, & costs. doi.org/10.1116/6.00...

Preparation of targeting nanogels for controlled delivery of 5-aminolevulinic acid triggered by matrix metalloproteinases as photodynamic therapy 5-Aminolevulinic acid (5-ALA) is a prodrug of the photodynamic therapy (PDT) for the treatment of certain skin diseases and neuronal cancers in the clinic. Howe

Folate-functionalized #nanogels were developed to improve delivery of prodrug 5-ALA for tumor treatment. They enhanced drug uptake in cancer cells, increased stability, & minimized side effects, showing promise for better-targeted therapies.
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Performance of biological food processing interfaces: Perspectives on the science of mollusc radula The Mollusca comprises a diverse range of organisms, with the class Gastropoda alone boasting approximately 80 000 extant species. Their adaptability across var

The phylum #Mollusca's adaptability is due to the radula, a specialized mouthpart for food gathering. Researchers examined radular types and #biomechanics across species, revealing insights into mollusk evolution, #bioengineering and #climatechange impacts. @uni-hamburg.de doi.org/10.1116/6.00....

Microfabricated free standing, tuneable, porous microfilters from an epoxy based photoresist for effective bioseparation SU-8 is an epoxy-based, biocompatible thermosetting polymer, which has been utilized mainly to fabricate biomedical devices and scaffolds. In this study, thin,

Authors from IIT Madras fabricated a thin, single-layered microfilter from the polymer SU-8. With tunable pore sizes, it separates plasma from blood cells & waste from fermented broth. It's stable, reusable & holds potential for #hemodialysis applications.
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Polydopamine modification of polydimethylsiloxane for multifunctional biomaterials: Immobilization and stability of albumin and fetuin-A on modified surfaces The surface of polydimethylsiloxane (PDMS) can be modified to immobilize proteins; however, most existing approaches are limited to complex reactions and achiev

Modifying #PDMS surfaces with #polydopamine immobilizes proteins, enhancing binding, stability & retention. Researchers from @mcmasteruniversity.bsky.social show how simultaneous & sequential immobilization of bovine albumin & fetuin-A in plasma retained >90% of the proteins.
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Integrating shear flow and trypsin treatment to assess cell adhesion strength Cell adhesion is of fundamental importance in cell and tissue organization and for designing cell-laden constructs for tissue engineering. Prior methods to asse

From @olddominionu.bsky.social: a new shear flow assay uses off-the-shelf parallel plate chambers & simultaneous #trypsin treatment to assess #celladhesion strength. It’s high-throughput and adaptable, allowing morphological analysis of both weakly & strongly adherent cells.
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Development of corneal contact lens materials and current clinical application of contact lenses: A review Unlike conventional glasses, corneal contact lenses (CLs) can directly contact the surface of the tear film through the application of biopolymer materials, to

#Contactlenses are worn by 150 million people for both vision correction & therapeutic purposes. Advances in materials aim to improve comfort, safety & functionality. Exciting progress has been made in the fields of #drugrelease & #biosensors. @avs-members.bsky.social
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Role of sequence length and functionalization in interactions of bioconjugated peptides with mitomembranes Cell-penetrating peptides are efficient tools for intracellular delivery of a variety of cargoes. In this study, we explored the effect of chain length, side ch

How do chain length, side chain chemistry & conjugate positioning influence iron-chelating #peptides' interaction with mitochondrial membranes? The study featured on our latest cover has the answers. @uofnh.bsky.social doi.org/10.1116/6.00...

Fungal mycelia: From innovative materials to promising products: Insights and challenges In transitioning toward a sustainable economy, mycelial materials are recognized for their adaptability, biocompatibility, and eco-friendliness. This paper upda

2024 Future of Biointerface Science Perspective: An updated overview of opportunities and challenges in the development of mycelilal materials, and their potential use in packaging, construction and #biomedical applications. #sustainablematerials @avs-members.bsky.social doi.org/10.1116/6.00...

The Goldilocks Principle in Biomaterials and Biointerfaces - AIP Publishing LLC

In biological processes, analogous to the Goldilocks fairytale, there are often “just right” conditions crucial for proper functioning. This collection will include examples applied to optimize biomaterials & interfaces for various applications. tinyurl.com/4kn5b54a