Ok, so this is pretty awesome actually!
24.02.2026 18:05 —
👍 1
🔁 0
💬 0
📌 0
How X-rays and crystals revealed the true nature of things - NobelPrize.org
The story behind the 100-year-old discovery that continues to render Nobel Prizes.
Very excited to share my love of crystallography in this article celebrating over 100 years of X-ray methods and the Nobel Prize for BBC and the Nobel Foundation:
www.nobelprize.org/stories/x-ra...
11.02.2026 17:54 —
👍 48
🔁 10
💬 0
📌 1
One Western is worth 7 meetings! Hopefully you got lunch
11.02.2026 01:57 —
👍 1
🔁 0
💬 0
📌 0
Thanks Tig, definitely looking forward to seeing how this line of research develops further!
09.02.2026 20:52 —
👍 1
🔁 0
💬 0
📌 0
Fellow new PI success PSA! @krishnamudumbi.bsky.social et al have an awesome preprint out! Super psyched to connect with @jasonzxzhang.bsky.social as well, I see collaborations in our future 😀
09.02.2026 01:28 —
👍 5
🔁 1
💬 2
📌 0
It was such a fun journey working with Krishna’s lab and @kinasekid.bsky.social! Really excited to see where this phospho-binder technology goes!
29.01.2026 13:40 —
👍 7
🔁 2
💬 0
📌 0
A graduate student in a pink hoodie and blue jeans pinning up her first publication on a cork board.
The inaugural pinning of a paper on our publications board!
Proud #NewPI moment!
29.01.2026 18:19 —
👍 1
🔁 0
💬 0
📌 0
Thanks Chrystal, so proud of my team!
29.01.2026 15:52 —
👍 1
🔁 0
💬 1
📌 0
De novo design of phosphotyrosine peptide binders
Phosphorylation on tyrosine is a key step in many signaling pathways. Despite recent progress in de novo design of protein binders, there are no current methods for designing binders that recognize phosphorylated proteins and peptides; this is a challenging problem as phosphate groups are highly charged, and phosphorylation often occurs within unstructured regions. Here we introduce RoseTTAFold Diffusion 2 for Molecular Interfaces (RFD2-MI), a deep generative framework for the design of binders for protein, ligand, and covalently modified protein targets. We demonstrate the power and versatility of this method by designing binders for four critical phosphotyrosine sites on three clinically relevant targets: Cluster of Differentiation 3 (CD3ε), Epidermal Growth Factor Receptor (EGFR), Insulin Receptor (INSR) and Signal Transducer and Activator of Transcription 5 (STAT5). Experimental characterization shows that the designs bind their phosphotyrosine containing targets with affinities comparable to native binding sites and have negligible binding to non-phosphorylated targets or phosphopeptides with different sequences. X-ray crystal structures of generated binders to CD3ε and EGFR are very close to the design models, demonstrating the accuracy of the design approach. A designed binder to an EGFR intracellular region phosphorylated upon EGF activation co-localizes with the receptor following EGF stimulation in single-particle tracking (SPT) experiments, demonstrating pY specific recognition in living cells. RFD2-MI provides a generalizable all-atom diffusion framework for probing and modulating phosphorylation-dependent signaling, and more generally, for developing research tools and targeted therapeutics against post-translationally modified proteins. ### Competing Interest Statement The authors have declared no competing interest. NIH NCI, 1K99CA293001
Not new, but a new to us update:
The first preprint out of my lab! We joined forces with @kinasekid.bsky.social @jasonzxzhang.bsky.social and David Baker to study protein phosphorylation! Congrats to Isabella from my lab on her first first author paper! tinyurl.com/43jwwfua
29.01.2026 12:57 —
👍 23
🔁 4
💬 2
📌 3
Three people sitting around the board game Carcassonne with cookies and coffee
Impromptu board games and cookies for those of us that lost power doing Snowmageddon!
26.01.2026 02:40 —
👍 2
🔁 0
💬 0
📌 0
8 people sitting at a long table with drinks and menus
Mini golf with @phdgprotein86.bsky.social and Jeeyeon Cha's labs, followed by pizza!
Great way to kick off the first lab outing of the year!
23.01.2026 03:14 —
👍 2
🔁 1
💬 0
📌 0
A collage of two pictures. On the left is a picture of 6 people in a tissue culture room doing work. On the right is a picture of 4 people stacking two incubators on top of each other.
At the one year mark, and we went from stacking incubators to a packed TC room!
#NewPI
14.01.2026 01:28 —
👍 8
🔁 0
💬 0
📌 0
A 35 year old letter to the editor, written by a very ballsy 15 year old, about the Rodney King verdict.
Remembering today that having your heart broken is a necessary step on the path to becoming fully human. Whichever heartbreak is your first, it’s probably critical that a state break your heart so that you can develop a political imagination. If this is your first, I’m sorry and also welcome.
08.01.2026 22:33 —
👍 12186
🔁 2496
💬 85
📌 118
Burnette Lab paper: "Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC-Derived Cardiac Myocytes" is out! This image is of beta myosin II filaments in an iPSC-derived cardiac myocyte. #CellBiology
onlinelibrary.wiley.com/doi/10.1002/...
07.01.2026 17:25 —
👍 10
🔁 3
💬 3
📌 0
Anything from Tool really, but Ænima is a classic from the mid 90s
28.12.2025 04:26 —
👍 4
🔁 0
💬 0
📌 0
8 people sitting around a poker table with cards and poker chips on the table.
High stakes poker game at the CDB holiday party with my office at stake!
Rest assured that I managed to keep my office - the PI poker face is a real thing!
13.12.2025 20:28 —
👍 3
🔁 0
💬 0
📌 0
Happy Nobel Prize Day to those that celebrate! Thanks for highlighting our work its connection to Stanley Cohen!
10.12.2025 23:55 —
👍 8
🔁 1
💬 0
📌 0
Happening tomorrow! Bring your own coffee 😁
09.12.2025 15:37 —
👍 4
🔁 1
💬 0
📌 0
Excited to host this session on Wednesday with these lovely ladies and some new friends that we made as well! Come check out the amazing talks that were selected!
09.12.2025 00:59 —
👍 6
🔁 2
💬 0
📌 0
5 people in front of the ASCB Cell Bio 25 sign
Just two new PIs and our labs! @adelitadmendoza.bsky.social @ascbiology.bsky.social #CellBio25
08.12.2025 13:03 —
👍 24
🔁 3
💬 0
📌 0
I'm such a sucker for beautifully animated biological processes! This is a really great watch!
03.12.2025 05:38 —
👍 3
🔁 0
💬 0
📌 0
I found myself fully agreeing with and reflected by this essay and felt that it really hit the mark for me!
I find that being my authentic silly self makes me a better scientist and, hopefully, a better mentor (I'll report back on the latter bit in a few more years with more data points)!
26.11.2025 07:34 —
👍 7
🔁 0
💬 0
📌 0
Awesome, congrats @biophysgal.bsky.social!
07.11.2025 23:05 —
👍 1
🔁 0
💬 0
📌 0
Candid photo of Zara Weinberg. She has short red hair, bangs and glasses. She is laughing.
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
05.11.2025 17:48 —
👍 148
🔁 85
💬 2
📌 12
The Prada glasses cracked me up!
01.11.2025 11:20 —
👍 4
🔁 0
💬 1
📌 0
It was a lovely night, and thanks for breaking in what will now be a long and storied tradition of rooftop bar night caps!
28.10.2025 04:41 —
👍 3
🔁 0
💬 0
📌 0
The reveal was so ridiculous, they could barely hold it together 😂
27.10.2025 19:53 —
👍 2
🔁 0
💬 0
📌 0
