Florencia Pratto

Protecting double Holliday junctions ensures crossing over during meiosis - Nature Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu

@univie.ac.at
@meduniwien.ac.at

YouTube video by Stowers Institute for Medical Research How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...

A complete diploid human genome benchmark for personalized genomics Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

Woohoo! That's great news! Congratulations!!! 🎉🎉🎉🎉

A phylogeny of the 7 ape genomes that have now been completed from "T2T", with Homer Simpson representing mankind.

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

Check this out if you ever wondered what intercellular bridges might be doing during meiosis! Happy to have played a small role! Congrats!!! @thejainlab.bsky.social

This is an important shift - the long awaited new Ensembl web site is ready for beta testing - is smooth, scrollable genome loveliness +clean views of the complex information - but @ensembl.bsky.social needs your help to get all the use cases out. Come to the webinar, and check out beta.ensembl.org

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

Argonaute proteins regulate the timing of the spermatogenic transcriptional program Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...

Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA

biorxiv.org/cgi/content/...

Sii, fracias! Por dónde andan ustedes? Besos!

View of the Playa Mansa in Punta del Este, crystal clear water with Isla Gorriti in the background

Home sweet home... New Year in the summer! #puntadeleste #uruguay

Exploring Meiosis in Brown Algae: Meiotic Axis Proteins in the model brown alga Ectocarpus Most extant eukaryotic systems share core meiosis-specific genes, suggesting meiosis evolved only once in the last eukaryotic common ancestor (LECA). These genes have been characterized as master regu...

New preprint! How does meiosis work in non-model organisms? Together with Susana Coelho at the MPI for Biology Tübingen @mpi-bio-fml.bsky.social , we took a look at the proteins of the meiotic axis in the brown alga Ectocarpus www.biorxiv.org/content/10.1...

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Pic of the game showing Botafogo up by two goals, playing with 10 players since minute 1

Uff Botafogo! 1 player down, 2 goals up!
#CopaLibertadores

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2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭🪱🪰🧬🦠Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIs🎉 #meiosis4eva

Congratulations! Happy to have you around!

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pa...

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries. #CrossoverRecombination #Chromosomes #Meiosis #TrendsInGenetics
www.cell.com/trends/genet...

Group Leader Position in Plant Chromosome Biology (m/f/d)

The Chromosome Biology Department of @raphmercier.bsky.social here at the Max Planck Institute for Plant Breeding Research Cologne (@maxplanck.bsky.social) is looking for a new group leader!

jobs.mpipz.mpg.de/jobposting/8...

#PlantScience #PlantSciJobs #GroupLeader #NewPI #PlantChromosomalBiology

Fantastic resource for bio icons: NIH Bioart Source

Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov

Infographic detailing the chemistry behind four kitchen chemistry hacks. The first is slowing fruit browning. Fruits brown due to oxidation and polymerization of phenols. Adding acids, such as lemon juice, wrapping fruit in cling film or otherwise blocking oxygen slows browning, reducing the activity of the polyphenol oxidase enzyme. You can brown onions more quickly by increasing the pH with baking soda, deprotonating amines so they react with sugars faster. Onions make your eyes water when chopped due to the production of propanethial S-oxide. A sharp knife damages onion cells less, reducing eye-watering reactions. Chilling onions before chopping reduces the rate of the reaction and the volatility of propanethial S-oxide. Warming cheese, water, milk, and sodium citrate makes a stable, smooth cheese sauce. Sodium ions replace calcium ions that hold casein proteins in cheese together. This allows the casein proteins to separate and act as emulsifiers, binding fat and water together

It's #InternationalNachoDay!

This graphic on kitchen chemistry hacks in @cenmag.bsky.social features tips on making a creamy nacho sauce as well as a guac that doesn't brown: cen.acs.org/food/food-sc...

🧪What a beautiful work has just been published.

This study reveals the mechanisms behind egg release during ovulation.

Looking at those images and videos is like visiting a museum. Pure art!
🔗 www.nature.com/articles/s41...

Picaña al gancho! Not many grilling days left this year...

People Are Not Peas—Why Genetics Education Needs an Overhaul The dated genetics taught in U.S. schools stokes misconceptions about race and human diversity. A biological anthropologist calls for change.

“I quickly learned most undergraduates in my classes still hold the pre-Lewontin belief that human genetic variation predominately sorts geographically. Many students also thought race was based in genetic differences & that single mutations could explain complex traits in humans”

Two new chapters from my free online book in human genetics out this weekend!
These complete Part 3 of the book, on human population structure and history:
3.3: Human prehistory [separate thread]
3.4: Ancient DNA: a genetic time capsule [this thread]
web.stanford.edu/group/pritch...

The final program for the conference is now up: events.columbia.edu/cal/event/ev...

So cool!

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1 Using five complementary short- and long-read sequencing technologies, we phased and assembled >95%

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1