Thomas Boettcher

Congratulations, David!

3/3 🐝CoE Postdoc @davidszamosvari.bsky.social from @thomasboettcher.bsky.social lab @Faculty of Chemistry @univie.ac.at explores specialized enzymes breaking down complex wax esters in human skin, beeswax, and plant cuticles.
More info: www.microplanet.at/index.php/re...

Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on his ERC Proof of Concept Grant! 👏 His project, PhageTRAP, uses a modular platform to capture and release phages to tackle antibiotic resistance and advance biotech. @fwf-at.bsky.social @erc.europa.eu #MicroSky #AMR #ERCPoC

Der Chemiker @thomasboettcher.bsky.social erhält einen Proof of Concept Grant des @erc.europa.eu. Wir gratulieren herzlichst! 🎉
Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪

Proud to see our work on bacteriophage inhibitors featured on one of the covers of the first issue of this year of
@rscchembio.rsc.org

Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on securing @fwf-at.bsky.social funding for Collaborative Research Centre with @dfg.de. Focus on bacterial effector proteins, infection mechanisms, and therapeutic strategies. cemess.univie.ac.at/news-detail/...

Congratulations to Thomas Böttcher and his team @univie.ac.at, Faculty of Chemistry | #CeMESS) on @fwf-at.bsky.social “International – Multilateral Initiatives” funding alongside @dfg.de for “CRC 1756”!
Learn more 🔗 cemess.univie.ac.at/news-detail/...

The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles - Scientific Reports Scientific Reports - The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles

Just hot from the press: nice work by Konstantin Plöchl of our lab on solute binding proteins of P. aeruginosa out now in Scientific Reports.

www.nature.com/articles/s41...

We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological… | Thomas... We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological questions...

www.linkedin.com/feed/update/...

Uni Vienna awards 20 postdoctoral positions for 4 years to outstanding female scientists. Our lab boettcher-lab.univie.ac.at participates as host in the field of chemical biology. Eligibility: female, PhD in 2022 or after
The E-STEEM call opens on 07.01.2026:
careers.univie.ac.at/en/postdoc/e...

New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab @univie.ac.at with colleagues from @tumunich.bsky.social introduces High-Level Oxidative Stress (HiLOS) response that enables strong oxidative agents to activate prophages. pubs.rsc.org/en/content/a...

New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab with first author Konstantin Plöchl @univie.ac.at identified a new class of phage blockers, enabling detailed study of phage's role in IBD, diabetes, and infections. pubs.rsc.org/en/content/a...

We are excited to be part of the newly approved SFB contributing from @univie.ac.at to this wonderful collaborative research centre!

A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress We identified a prophage-selective induction in poly-lysogenic Staphylococcus aureus induced by certain phenazines, such as pyocyanin, produced by Pseudomonas aeruginosa. Using a focused library of ph...

Check out our latest work, which got just published in Chemical Science. The study about SOS-independent prophage induction was led by Dr. Magdalena Jancheva: pubs.rsc.org/en/content/a... @univie.ac.at #phages #chemicalbiology #FWF #ERC

Our latest research just accepted in RSC Chemical Biology:
pubs.rsc.org/en/content/a...
In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology
@univie.ac.at

The text reads: “Resistance to antibiotics is widespread and increasing, threatening treatment of common infections. 1 in 6 bacterial infections worldwide were resistant to antibiotics in 2023.”

New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments.

Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.

Read more 👉bit.ly/438Ta1u

Honest answer: getting the funding to do it. The science behind it is beautiful and just works.

Survey on the clinical need for an ultra-narrow spectrum N. gonorrhoeae Antibiotic Welcome and thank you for participating in this survey! We are the researchers in Boettcher's group at University of Vienna, who are developing the new antibiotic specifically targeting N. gonorrhoeae...

For our antimicrobial drug development efforts at the University of Vienna we are looking for input from physicians/clinicians who are familiar with treatment, diagnostics, infection control, etc.
Your insights would be highly valuable!

docs.google.com/forms/d/e/1F...

Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting There is much interest in the development of dietary supplements that selectively promote the growth of beneficial gut bacteria. The selectivity of many candidate prebiotics has, however, not been ...

Wonderful work in collaboration with the lab of @davidberry1.bsky.social

www.tandfonline.com/doi/full/10....

Good to read an informed scientific opinion on this topic. I couldn't agree more. Safety considerations for additives regardless whether synthetic or natural should be only based on scientific data and not on ideology or personal beliefs.

Please only apply online via the weblink. Skills in organic chemistry, NMR, natural product chemistry, chemical biology and biochemistry are desired, expertise in microbiology is a plus but alone not sufficient. @chemjobber.bsky.social @cemess.bsky.social #PhD #ChemicalBiology

We are looking for an excellent and highly motivated PhD student in Chemical Biology for a position in our group within the AIDD docfunds program @univie.ac.at to investigate anti-infectives from antagonistic microbial interactions. Apply until 03.05.2025:
vds-phanuspo.univie.ac.at/application/...

A new cover feature from our lab, designed by first author Viktoriia Savchenko, went online in ACS Chemical Biology.
Here is the article link: pubs.acs.org/doi/10.1021/...
@univie.ac.at @cemess.bsky.social

A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature Microbiology Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...

💊🦠OUT NOW - new research showing that 2-nonyl-4-quinolone N-oxide and its 3-methyl derivative kill Neisseria gonorrhoeae in vitro and significantly reduce bacterial numbers in vivo, in mouse infection models

#MicroSky

www.nature.com/articles/s41...

A chemical radar allows bacteria to detect and kill predators Pseudomonas syringae can detect and kill microbial predators via a chemical radar (Cra), which also allows the bacterium to infect plants despite predation pressure.

#weekendreading🔬

A chemical radar allows bacteria to detect and kill predators

@cellpress.bsky.social #microsky

www.cell.com/cell/fulltex...

A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature Microbiology Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...

and here is the link to our nature microbiology paper, which is open access:

www.nature.com/articles/s41...

New antibiotic for multidrug resistant superbug, that causes gonorrhoea This novel antibiotic activates an existing "suicide" mechanism in gonococci

Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social

medienportal.univie.ac.at/en/media/rec...

Neues Antibiotikum gegen Problemkeim, der Tripper (Gonorrhö) auslöst Neuartiges Antibiotikum aktiviert einen in den Gonokokken bereits vorhandenen Selbsttötungsmechanismus

Die Zunahme von antibiotikaresistenten Keimen ist ein wachsendes Problem. Dazu gehört etwa der Problemkeim Neisseria gonorrhoeae, der Tripper (Gonorrhö) auslöst. Forscher*innen der Universitäten Konstanz und Wien entdeckten nun eine neue Klasse von Antibiotika, die selektiv dagegen wirken. 💊

Research-team of #UniKonstanz + @univie.ac.at have identified a new class of antibiotics that selectively target Neisseria gonorrhoeae—the bacteria behind gonorrhea. Full story: https://t1p.de/7svjt @naturebicrobiol.bsky.social. Read scientific publication: https://t1p.de/wtlae

New @fwf-at.bsky.social CoE Microplanet Publication in ASC Chemical Biology from the lab of @thomasboettcher.bsky.social @cemess.bsky.social @univie.ac.at unveils Chitinivorax as a new quinolone-producing genus. Check out the publication ➡ pubs.acs.org/doi/10.1021/...