Single-color 3D MINFLUX of periodic paralemmin-1 along the axon of a mature neuron. YFP-Palm1 was detected with a nanobody against YFP with DNA-PAINT. Image courtesy: @vmacarron.bsky.social, MPI MR, Heidelberg, Germany
More in the paper www.science.org/doi/full/10....
#fluorescencefriday
Are you interested in muscle research? 💪 🏋
We are excited to invite you to our Muscle Mini-Symposium: “Exploring skeletal muscle communication: From tissues down to molecules”
🗣️ Speakers: Fanny Sage, Ana Banito, Xuejun Yuan, Joerg Heineke
Many Thanks and Kudos to all authors, colleagues and collaborators from Heidelberg and Göttingen. Looking forward to what comes next!
08.03.2025 10:05 — 👍 1 🔁 0 💬 0 📌 0
How does it work? The expression level of Paralemmin-1 controls the degree of periodicity of the MPS.
⬇️Low levels: poorly organized MPS
⬆️High levels: tightly organized MPS
Paralemmin-1 binds ßII-spectrin and is located in close proximity to actin and adducin
#STED #MINFLUX #Y2H
🔬🧠We are pleased to announce that our work on Paralemmin-1 as a powerful regulator of the neuronal submembrane cytoskeleton has been published in Science Advances @science.org! Read the full study here: www.science.org/doi/10.1126/...
#Neuroscience
Time for changes! New week, new month, new platform. Hi scientific community!
03.03.2025 15:17 — 👍 7 🔁 1 💬 0 📌 0