Dr. Todd Ewing PhD.

What foods make you happiest? It's not what you think As you prepare for your holiday feast, here's something to consider. Research suggests there are certain foods that can help boost our moods and make us happier in the long-run.

Nutritional psychiatry finds foods for good mood

www.npr.org/2025/11/24/n...

> Home cooked vs processed
> Avoid white breads
> Beans legumes for fiber

#health #science 🧪

A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo - npj Aging npj Aging - A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo

Swiss researchers identify amino acid #supplementation to promote collagen & #longevity!

www.nature.com/articles/s41...

— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans

#science 🧪

L-serine binds to NMDA receptor and stimulates excitatory activity of cell membrane signaling potentially rescuing weak activity of GRIN2A variant NMDAR

Congratulations to

Hasso-Plattner-Institut
@hpi.bsky.social
@aeoli.bsky.social
@hheyne.bsky.social

GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy - Molecular Psychiatry Molecular Psychiatry - GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy

Here's the source article

www.nature.com/articles/s41...

GRIN2A null variants confer high risk early-onset schizophrenia mental disorders & potentially enable precision therapy

@atanas-g-atanasov.bsky.social
@mariaoconnor.bsky.social
@nonlinearbotanist.bsky.social
@mfamyfuerza.bsky.social

Changes in a single gene can cause mental illness, study reveals Until now, researchers assumed that schizophrenia, anxiety disorders or depression arise from an interplay of many different factors, including genetic ones.

Variants of single gene GRIN2A linked to early onset of mental illness particularly schizophrenia

medicalxpress.com/news/2025-11...

— 121 ppl with GRIN2A variant analyzed
— GRIN2A variants reduce activity of NMDA receptor
— 4 patients benefit with dietary supplement L-serine

#health #science 🧪

Physicians should evaluate patients' #nutrition & #exercise #fitness every check-up

— What did you eat yesterday? Typical day?
— How much did you move yesterday? Typical day?
— How many push-ups, sit-ups, pull-ups can you do?
— How high is your vertical leap?
— How fast is your 100m walk/run?

🥗🏃‍♂️🏋️‍♂️

Do doctors know that it takes more than an apple a day? Impact of formal nutrition training on family medicine residents’ nutrition knowledge, confidence, attitudes, and counselling abilities: a singl... Background Malnutrition and poor dietary intake are major health challenges today. There are well-established benefits of nutrition interventions, but a lack of formalized nutrition training in medica...

Canadian researchers show #medical training must include #nutrition

bmcmededuc.biomedcentral.com/articles/10....

— Physicians lack knowledge, skills, confidence, training to effectively counsel nutrition
— Nutrition training during residency fixes
— More evidence-based training guidelines needed

🧵1/6
📢 New meta-analysis shows lifestyle changes + GLP-1RAs lead to major weight loss & biomarker gains!
🔗 www.linkedin.com/feed/update/...

🌐 #GLP1 #DHPSP @hipecsurvivor.bsky.social @martinbue.bsky.social @shawneexo.bsky.social @holyunknown.bsky.social @alisyngayle.bsky.social @ustinoff.bsky.social

🧵 [3/6]
🩺 Cardiometabolic boost: lower blood pressure, HbA1c, cholesterol with GLP-1RA + lifestyle combo.

🌐 #CardioHealth #Diabetes #GLP1RA @manjeet786.bsky.social @alfredodistefano.bsky.social @nicksevillaz.bsky.social @spatzlhirn.bsky.social @ewingt-phd.bsky.social

#heart health linked to #gut health via dietary #fiber

www.acc.org/Latest-in-Ca...

— feeds good gut bacteria
— lowers inflammation, cholesterol, blood sugar
— lowers cholesterol, BP, body weight
— 25-38 g fiber/d from fruits, vegetables, legumes, whole grains

#cardiovascular #diet #longevity

Preservation of Autophagy May Be a Mechanism Behind Healthy Aging Using CD4+ T cells from pairs of young and old healthy human donors, we found that autophagy in the older donor cells did not decline with aging suggesting a compensatory enhanced autophagic efficien...

Here's the source article:

Preservation of Autophagy May Be a Mechanism Behind Healthy Aging
onlinelibrary.wiley.com/doi/full/10....

@atanas-g-atanasov.bsky.social
@mfamyfuerza.bsky.social
@desolationrow.bsky.social
@spfisterer.bsky.social
@oonawest.bsky.social
@jrmansfield.bsky.social

Maintenance Stays Efficient in Healthy Older People’s Cells Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. […]

Healthy #aging linked to increased #autophagy efficiency

www.lifespan.io/news/mainten...

— greater autophagy in older adults may be result of larger amount of damaged material
— autolysosomes more heterogenous & may be less resilient to stress

via @lifespanio.bsky.social
#science 🧪

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice - GeroScience Obesity and type 2 diabetes mellitus accelerate aging, shortening the duration of healthspan. Conversely, chronic calorie restriction (CR) extends healthspan. Research aimed at understanding the mecha...

Here's the source article:

link.springer.com/article/10.1...

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice

@atanas-g-atanasov.bsky.social
@nutriclarity.bsky.social
@oneresolve.bsky.social
@savoy234ever.bsky.social

U of A scientists link calorie restriction, glucagon, healthy aging A team from the Division of Endocrinology found that treatment with glucagon may induce similar metabolic benefits as caloric restriction, potentially slowing aging.

Researchers @uarizona.bsky.social uncover glucagon role in #aging & #longevity

research.arizona.edu/news/u-scien...

— glucagon critical for healthspan stimulated by calorie restriction
— glucagon agonism in aging mice suppresses pathways that accelerate aging

#health #science #research 🧪

Okay I work in pharmaceuticals, and mass production efficiencies can lower the cost of goods, but are you considering the full cost of R&D on all the failed drug projects in your $15?

I'm personally excited by California's effort to produce generic medicines, in which cost of goods is favorable!

Right on!

Here in the US we have 24-Hour Fitness

Maybe some longevity influencer will open an 8-HOUR NUTRITION & FITNESS!

Fascinating

Worth a shot

I'm no expert in this area, but it appears that FODMAP sensitivity can be overcome by temporary elimination & gentle re-introduction

The role of the SIRT1 and mTOR pathways in exercise-induced β-cell senescence reduction in type 2 diabetes mellitus - Cellular and Molecular Life Sciences Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, chronic hyperglycemia, and pancreatic β-cell dysfunction, driven in part by cellular senescence and chronic inflammation. The si...

Iranian researchers describe how #exercise protects #pancreas beta cells from type 2 #diabetes

link.springer.com/article/10.1...

— incr NAD⁺ levels, AMPK, SIRT1
— decr mTOR

Improving:

— autophagy
— oxidative stress
— mitochondrial function
— β-cell mass & function

🧪 #health #science #research

Based on my understanding of the article by Dr. Jessica Biesiekierski, Associate Professor of Human Nutrition, gluten sensitive individuals can experiment with temporarily withholding various FODMAP nutrients to treat acute discomforts.

Sourdough might be a way to re-introduce a FODMAP nutrient

How to Die Young at a Very Old Age Longevity researcher Nir Barzilai shares how interfering with aging could prevent myriad diseases.

Longevity researcher Dr. Barzilai shares his thoughts on the field

time.com/7330284/agin...

— Optimize sleep, exercise, diet, social connectivity
— Intermittent fast 16 hours every day
— lost some weight
— gained muscle
— lost the fogginess during the day

Also under-discussed is what happens when the current renovation finishes and Trump proceeds to demolish the rest of the White House and install something like a Trump Tower?

Great points!

Totally agree!

Right on!

Yes, I suspect both nutrition and exercise have optimum daily patterns

Exercise late in the day is paradoxically unhealthy relative to earlier

I try to keep an eye out for further research and discovery on circadian health & fitness!

Basically any nutrient that can be fermented in the gut

en.wikipedia.org/wiki/FODMAP

Obviously fermentation is healthy and prebiotic dietary fiber promotes a diverse comensal microbiome

But some people may experiment with particular FODMAP food categories to relieve acute discomfort

"[W]hat else could explain why some people feel better after going gluten-free? Such a change in the diet also reduces high-FODMAP foods and ultra-processed products, encourages mindful eating and offers a sense of control. All these can improve our wellbeing."

Non-coeliac gluten sensitivity Non-coeliac gluten sensitivity (NCGS) refers to individuals who report intestinal and extraintestinal symptoms related to the ingestion of gluten-based or wheat-based foods, in the absence of coeliac ...

Here’s the source article

Non-coeliac gluten sensitivity

www.thelancet.com/journals/lan...

@atanas-g-atanasov.bsky.social
@jrmansfield.bsky.social
@mariaoconnor.bsky.social
@srzjswalters.bsky.social
@chilirlw.bsky.social
@debbiefearon.medsky.social

Your gluten sensitivity might be something else entirely, new study shows A new study shows gluten itself is rarely the cause of gut problems, whatever people think. But symptoms are real. So what’s really going on?

#Gluten sensitivity may actually be FODMAP sensitivity

theconversation.com/your-gluten-...

#glutenfree risks:

> 139% more expensive
> lower in fiber & key nutrients
> reduces diversity in diet
> alters gut microbes
> reinforces anxiety about eating

🧪 #health #science #diet

I love thinking about which cells are the highest masters of the organism, the neurons or the immune cells

I suspect the immune cells might be the ultimate boss cells

I'm tinkering with a Regulation Theory of Aging, in which loss of regulation within cells AND between cells both contribute to physiological dysregulation and the aging phenotype