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Patrick Forcelli

@paf1984.bsky.social

Neuropharmacologist @ Georgetown University, Prof & Chair, Dept of Pharmacology & Physiology. Preclinical epilepsy researcher & basal ganglia nerd. πŸ³οΈβ€πŸŒˆ

91 Followers  |  126 Following  |  29 Posts  |  Joined: 23.01.2025
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Posts by Patrick Forcelli (@paf1984.bsky.social)

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Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer’s Disease Executive dysfunction can precede the accumulation of canonical neuropathological markers and severe dementia in Alzheimer’s disease (AD) patients often characterized by memory changes. Deficits in ex...

Excited that our new paper is out today in the Journal of Neuroscience. www.jneurosci.org/content/46/6...

11.02.2026 18:14 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0
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πŸ“’ GU Pharmacology & Physiology is hiring!
Tenure-track / tenured faculty position at Georgetown University Medical Center.
apply.interfolio.com/180562

Please share with your networks.

30.01.2026 17:40 β€” πŸ‘ 2    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Don’t let Russell Vought trick Congress into destroying science by removing multiyear funding limits from the NIH funding bill.

16.01.2026 16:34 β€” πŸ‘ 315    πŸ” 149    πŸ’¬ 3    πŸ“Œ 9

If it helps, people are mad at Democrats because many of their social media presences produce comms which address what's happening as though we're simply dealing with the consequences of going along with a bad restaurant recommendation.

The food isn't just bad, we want to shut down the restaurant.

08.01.2026 18:28 β€” πŸ‘ 1820    πŸ” 251    πŸ’¬ 34    πŸ“Œ 5
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The Trump Administration’s Most Paralyzing Blow to Science Cuts to research may have spoiled the country’s appetite for bold exploration.

Sharing this piece by @katherinejwu.com - A succinct explanation about why i fear for the younger generation of scientists...
www.theatlantic.com/science/2025...

30.12.2025 15:28 β€” πŸ‘ 27    πŸ” 14    πŸ’¬ 2    πŸ“Œ 1
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Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice Objective The pharmacological treatment of temporal lobe epilepsy (TLE), a disorder characterized by recurrent seizures and cognitive dysfunction, is limited to symptomatic control. Identifying nove...

New paper out from the lab. Tahi Khan, David McFall, and team (1) found increased senescent cells in hippocampus from individuals with temporal lobe epilepsy and in mice after status epilepticus, (2) cleared senescent cells using two strategies & reduced seizures and cognitive impairment in mice.

23.12.2025 13:47 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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OMG this William G. Young opinion that just dropped (12:30pm) in AAUP v. Rubio.
It begins with a postcard sent to Chambers and Young's reply

card: "Trump has pardons and tanks, what do you have?"

WGY: "We the People of the United States β€” you and me β€” have our magnificent Constitution"

30.09.2025 16:41 β€” πŸ‘ 1448    πŸ” 449    πŸ’¬ 24    πŸ“Œ 94

Thank you all the program officers at NIH that persisted through the 2025 fiscal year and were able to fund 99% of the total FY2024 budget. I know this has take a toll on everyone at NIH. Thank you for supporting important health and behavior science and helping to keep the U.S. a leader in science.

29.09.2025 17:51 β€” πŸ‘ 194    πŸ” 34    πŸ’¬ 3    πŸ“Œ 2

My take away was that this was *not* saying "no new funding of animal only research" but rather that NIH will not release new NOFOs that are animal-only and that NOFOs need to consider non-animal methods...I think (hope) the drug discovery trends news piece is over-extrapolating.

08.07.2025 23:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
I'm trying to put together a portfolio of three to five papers to highlight my breadth and depth as a research scientist. (I'm Carl Bergstrom.)

Could you help me choose papers?
ChatGPT said:

Absolutely, Carl. Given your broad body of work across evolutionary biology, information theory, network science, metascience, and science communication, a strong portfolio should showcase both disciplinary depth and interdisciplinary reach. A good starting structure might be:

    Foundational work in evolutionary biology or theoretical ecology

    Papers at the intersection of information theory and biology

    Work in network theory or epidemiological modeling

    Metascience or science reform scholarship

    Public-facing or high-impact commentary on misinformation or science communication

Here’s a possible set of five papers that reflect this breadth and depth:

I'm trying to put together a portfolio of three to five papers to highlight my breadth and depth as a research scientist. (I'm Carl Bergstrom.) Could you help me choose papers? ChatGPT said: Absolutely, Carl. Given your broad body of work across evolutionary biology, information theory, network science, metascience, and science communication, a strong portfolio should showcase both disciplinary depth and interdisciplinary reach. A good starting structure might be: Foundational work in evolutionary biology or theoretical ecology Papers at the intersection of information theory and biology Work in network theory or epidemiological modeling Metascience or science reform scholarship Public-facing or high-impact commentary on misinformation or science communication Here’s a possible set of five papers that reflect this breadth and depth:

IMPORTANT PAPER BUT DATE IS OFF BY A DECADE

1. "The transmission sense of information" (2002, Biology and Philosophy)

    Why: A conceptual cornerstone in your work on biological information.

    Highlights: Philosophical rigor, interdisciplinary relevance, and enduring influence on how scientists think about information in biological systems.

I'VE NEVER WRITTEN ON THIS SUBJECT OR WITH THESE AUTHORS

2. "Evolutionary dynamics of viral marketing" (2008, PNAS, with K. Lerman and R. Hogg)

    Why: Demonstrates your application of mathematical models to real-world social phenomena.

    Highlights: Network theory, diffusion dynamics, interdisciplinary breadth (social + biological analogies).

I NEVER WROTE THIS OR ANYTHING LIKE IT
3. "The fundamental limitations of contact tracing for COVID-19" (2020, eLife)

    Why: A timely, policy-relevant paper that exemplifies your scientific leadership during the pandemic.

    Highlights: Mathematical epidemiology, real-world application, and high visibility.

IMPORTANT PAPER BUT DATE IS OFF BY A DECADE 1. "The transmission sense of information" (2002, Biology and Philosophy) Why: A conceptual cornerstone in your work on biological information. Highlights: Philosophical rigor, interdisciplinary relevance, and enduring influence on how scientists think about information in biological systems. I'VE NEVER WRITTEN ON THIS SUBJECT OR WITH THESE AUTHORS 2. "Evolutionary dynamics of viral marketing" (2008, PNAS, with K. Lerman and R. Hogg) Why: Demonstrates your application of mathematical models to real-world social phenomena. Highlights: Network theory, diffusion dynamics, interdisciplinary breadth (social + biological analogies). I NEVER WROTE THIS OR ANYTHING LIKE IT 3. "The fundamental limitations of contact tracing for COVID-19" (2020, eLife) Why: A timely, policy-relevant paper that exemplifies your scientific leadership during the pandemic. Highlights: Mathematical epidemiology, real-world application, and high visibility.

I NEVER WROTE ABOUT THIS AND NEVER PUBLISHED IN THIS JOURNAL

4. "Systematic inequality and hierarchy in faculty hiring networks" (2015, Science Advances)

    Why: Important contribution to the empirical study of academic hierarchies.

    Highlights: Data-driven metascience, strong methodology, and influence on debates about academic equity.

5. "Misinformation in and about science" (2021, PNAS)

    Why: Captures your role in science communication and misinformation research.

    Highlights: Interdisciplinary scope, impact on public discourse, and relevance in the post-truth era.

I NEVER WROTE ABOUT THIS AND NEVER PUBLISHED IN THIS JOURNAL 4. "Systematic inequality and hierarchy in faculty hiring networks" (2015, Science Advances) Why: Important contribution to the empirical study of academic hierarchies. Highlights: Data-driven metascience, strong methodology, and influence on debates about academic equity. 5. "Misinformation in and about science" (2021, PNAS) Why: Captures your role in science communication and misinformation research. Highlights: Interdisciplinary scope, impact on public discourse, and relevance in the post-truth era.

I tried something similar using ChatGPT 4.o.

"I'm trying to put together a portfolio of three to five papers to highlight my breadth and depth as a research scientist. (I'm Carl Bergstrom.)

Could you help me choose papers?"

Here's the result.

04.06.2025 05:13 β€” πŸ‘ 188    πŸ” 45    πŸ’¬ 12    πŸ“Œ 2
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R.I.P. RDoC? Part 1: Is it feasible to develop new psychiatric medications using RDoC guidances?

It has been more than 15 years since the RDoC recommendations were published. The RDoC recommendations have had no impact on psychiatric drug discovery to date.
zendudest.substack.com/p/rip-rdoc?r...

27.05.2025 23:30 β€” πŸ‘ 13    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1
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Senate Democrats Host Forum on HHS: Day 2 YouTube video by Senator Peter Welch

Video from the hearing yesterday

www.youtube.com/live/_Szx0jJ...

22.05.2025 09:52 β€” πŸ‘ 57    πŸ” 19    πŸ’¬ 9    πŸ“Œ 2
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Seizure Circuit Activity in the Theilers Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations. Epilepsy affects one in twenty-six individuals. A major cause of epilepsy worldwide is viral encephalitis. Central nervous system infections can provoke seizures in the short term and increase the ris...

Excited to have a new preprint describing the seizure circuit in a CNS infection model of temporal lobe epilepsy- great work from Alexandra Petrucci (not on bluesky.) #epilepsy www.biorxiv.org/content/10.1...

23.05.2025 09:58 β€” πŸ‘ 18    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Hear why neuroscientists πŸ§ πŸ§‘β€πŸ”¬ should be valued, globally πŸ—ΊοΈ! Prof Helen Scharfman 🀩 explains to us her #epilepsy research using mossy cells and the potential understanding them further may bring to people with anepilepsy and #anxiety! πŸ‘‡πŸ»

▢️ YouTube youtu.be/KHBqEYT1ThY
πŸŽ™οΈ Podcast shorturl.at/e7XWY

23.05.2025 09:50 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Georgetown Law and Dean William M. Treanor Honored for β€˜Upholding and Strengthening the Rule of Law’

At its 29th World Law Congress in Santo Domingo, Dominican Republic on May 6, the World Jurist Association (WJA) presented both #GeorgetownLaw and Dean William M. Treanor with awards recognizing their efforts to defend and advance the rule of law.

09.05.2025 14:18 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Georgetown's Lombardi Comprehensive Cancer Center, the Department of Pharmacology & Physiology, and the Department of Biochemistry and Molecular & Cellular Biology are looking for new colleagues. See the ad below.

29.04.2025 16:11 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
April 14, 2025
VIA ELECTRONIC MAIL
Josh Gruenbaum
Commissioner of the Federal Acquisition Service
General Services Administration
Sean R. Keveney
Acting General Counsel
U.S. Department of Health & Human Services
Thomas E. Wheeler
Acting General Counsel
U.S. Department of Education
Dear Messrs. Gruenbaum, Keveney, and Wheeler:
We represent Harvard University. We are writing in response to your letter dated April 11,
2025, addressed to Dr. Alan Garber, Harvard’s President, and Penny Pritzker, Senior Fellow of the
Harvard Corporation.
Harvard is committed to fighting antisemitism and other forms of bigotry in its community.
Antisemitism and discrimination of any kind not only are abhorrent and antithetical to Harvard’s
values but also threaten its academic mission.
To that end, Harvard has made, and will continue to make, lasting and robust structural,
policy, and programmatic changes to ensure that the university is a welcoming and supportive
learning environment for all students and continues to abide in all respects with federal law across
its academic programs and operations, while fostering open inquiry in a pluralistic community free
from intimidation and open to challenging orthodoxies, whatever their source.
Over the past 15 months, Harvard has undertaken substantial policy and programmatic
measures. It has made changes to its campus use policies; adopted new accountability procedures;
imposed meaningful discipline for those who violate university policies; enhanced programs
designed to address bias and promote ideological diversity and civil discourse; hired staff to
support these programs and support students; changed partnerships; dedicated resources to combat
hate and bias; and enhanced safety and security measures. As a result, Harvard is in a very different
place today from where it was a year ago. These efforts, and additional measures the university
will be taking against antisemitism, not only are the right thing to do but also are critical to
strength…

April 14, 2025 VIA ELECTRONIC MAIL Josh Gruenbaum Commissioner of the Federal Acquisition Service General Services Administration Sean R. Keveney Acting General Counsel U.S. Department of Health & Human Services Thomas E. Wheeler Acting General Counsel U.S. Department of Education Dear Messrs. Gruenbaum, Keveney, and Wheeler: We represent Harvard University. We are writing in response to your letter dated April 11, 2025, addressed to Dr. Alan Garber, Harvard’s President, and Penny Pritzker, Senior Fellow of the Harvard Corporation. Harvard is committed to fighting antisemitism and other forms of bigotry in its community. Antisemitism and discrimination of any kind not only are abhorrent and antithetical to Harvard’s values but also threaten its academic mission. To that end, Harvard has made, and will continue to make, lasting and robust structural, policy, and programmatic changes to ensure that the university is a welcoming and supportive learning environment for all students and continues to abide in all respects with federal law across its academic programs and operations, while fostering open inquiry in a pluralistic community free from intimidation and open to challenging orthodoxies, whatever their source. Over the past 15 months, Harvard has undertaken substantial policy and programmatic measures. It has made changes to its campus use policies; adopted new accountability procedures; imposed meaningful discipline for those who violate university policies; enhanced programs designed to address bias and promote ideological diversity and civil discourse; hired staff to support these programs and support students; changed partnerships; dedicated resources to combat hate and bias; and enhanced safety and security measures. As a result, Harvard is in a very different place today from where it was a year ago. These efforts, and additional measures the university will be taking against antisemitism, not only are the right thing to do but also are critical to strength…

recognized by the Supreme Court. The government’s terms also circumvent Harvard’s statutory
rights by requiring unsupported and disruptive remedies for alleged harms that the government has
not proven through mandatory processes established by Congress and required by law. No less
objectionable is the condition, first made explicit in the letter of March 31, 2025, that Harvard
accede to these terms or risk the loss of billions of dollars in federal funding critical to vital research
and innovation that has saved and improved lives and allowed Harvard to play a central role in
making our country’s scientific, medical, and other research communities the standard-bearers for
the world. These demands extend not only to Harvard but to separately incorporated and
independently operated medical and research hospitals engaging in life-saving work on behalf of
their patients. The university will not surrender its independence or relinquish its constitutional
rights. Neither Harvard nor any other private university can allow itself to be taken over by the
federal government. Accordingly, Harvard will not accept the government’s terms as an agreement
in principle.
Harvard remains open to dialogue about what the university has done, and is planning to
do, to improve the experience of every member of its community. But Harvard is not prepared to
agree to demands that go beyond the lawful authority of this or any administration.
William A. Burck Robert K. Hur
Quinn Emanuel Urquhart & Sullivan, LLP 1300 I Street NW Suite 900 Suite 900
Washington, DC 20005 King & Spalding LLP
1700 Pennsylvania Avenue NW
Washington, DC 20006

recognized by the Supreme Court. The government’s terms also circumvent Harvard’s statutory rights by requiring unsupported and disruptive remedies for alleged harms that the government has not proven through mandatory processes established by Congress and required by law. No less objectionable is the condition, first made explicit in the letter of March 31, 2025, that Harvard accede to these terms or risk the loss of billions of dollars in federal funding critical to vital research and innovation that has saved and improved lives and allowed Harvard to play a central role in making our country’s scientific, medical, and other research communities the standard-bearers for the world. These demands extend not only to Harvard but to separately incorporated and independently operated medical and research hospitals engaging in life-saving work on behalf of their patients. The university will not surrender its independence or relinquish its constitutional rights. Neither Harvard nor any other private university can allow itself to be taken over by the federal government. Accordingly, Harvard will not accept the government’s terms as an agreement in principle. Harvard remains open to dialogue about what the university has done, and is planning to do, to improve the experience of every member of its community. But Harvard is not prepared to agree to demands that go beyond the lawful authority of this or any administration. William A. Burck Robert K. Hur Quinn Emanuel Urquhart & Sullivan, LLP 1300 I Street NW Suite 900 Suite 900 Washington, DC 20005 King & Spalding LLP 1700 Pennsylvania Avenue NW Washington, DC 20006

BREAKING: On Friday, the federal government issued new demands of Harvard University. The university's lawyers just responded: back off.

14.04.2025 17:16 β€” πŸ‘ 4673    πŸ” 1112    πŸ’¬ 114    πŸ“Œ 254

Not so - apps are being rejected without review if the justification is missing, rather than missing info being requested at JIT, which was the case in the past.

14.04.2025 13:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

The courts *should* put an immediate and unequivocal halt to all use of the CECOT prison in El Salvador, with or without due process.

They may not do that.

But the *people* of the US still can. Don't lose of sight of this atrocity amidst the other outrages. Make this a key focus of resistance.

08.04.2025 21:02 β€” πŸ‘ 7677    πŸ” 1901    πŸ’¬ 111    πŸ“Œ 55
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Abstract submission for #AES2025 is OPEN! AES is the optimal venue to share your #epilepsy research with a global audience. Learn more and apply by 6/9: buff.ly/Zg7WM2T #brainscience #neurology #epilepsyresearch

03.04.2025 10:00 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

John Green did an amazing job with Everything is Tuberculosis. He manages to tell "people stories", inform on the history of medicine, and make a clear argument for public health policy in just over 200 pages. Well worth the read.

03.04.2025 11:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

cheese is woke now

02.04.2025 03:06 β€” πŸ‘ 23506    πŸ” 1931    πŸ’¬ 1053    πŸ“Œ 229

Safwan Hyder (a former MD/PhD student) and Willian Lazarini Lopes (a current postdoc) demonstrate a striking bi-directional modulation of seizures when they silenced and activated dorsal striatum. This effect was present in models of focal and generalized seizures.

31.03.2025 19:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures | PNAS Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy...

New paper from the lab: www.pnas.org/doi/10.1073/...

31.03.2025 19:23 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

Well done Columbia leadership and Paul Weiss...

27.03.2025 12:06 β€” πŸ‘ 92    πŸ” 30    πŸ’¬ 2    πŸ“Œ 0

Not getting much attention, but the Senate GOP is about to start voting - to make sure banks can charge higher overdraft fees. Seriously.

Good time to let your Senators know what you think of that.

27.03.2025 00:36 β€” πŸ‘ 64643    πŸ” 20495    πŸ’¬ 1630    πŸ“Œ 971
Post from Director of National Intelligence Tulsi Gabbard that reads: Any unauthorized release of classified information is a violation of the law and will be treated as such.

Post from Director of National Intelligence Tulsi Gabbard that reads: Any unauthorized release of classified information is a violation of the law and will be treated as such.

Circling back on this…

24.03.2025 19:09 β€” πŸ‘ 64505    πŸ” 14790    πŸ’¬ 1937    πŸ“Œ 915
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NEW: Baldwin, Welch Announce Former NIH Director, Researchers, Clinical Trial Patients as Witnesses for Forum on Trump’s NIH Cuts | U.S. Senator Tammy Baldwin of Wisconsin WASHINGTON, D.C. – Today, U.S. Senators Tammy Baldwin (D-WI) and Peter Welch (D-VT) announced the...

www.baldwin.senate.gov/news/press-r...

24.03.2025 22:28 β€” πŸ‘ 81    πŸ” 30    πŸ’¬ 0    πŸ“Œ 6