3Dneuro

Still at SfN on the last day? During the morning session on the 19th, 8:00AM - 12:00PM, come check out our posters from the Moser, Zong, and Gonzalo Cogno groups in row QQ ('Grid cells and spatially modulated cells'). Ephys, imaging, remapping, development, sweeps and more! 🧠
Detailed thread below 👇

Reposting this from #SfN25 in San Diego, where this collaboration takes off in fashion! 📣 🥳

Hi Thomas, if I understand correctly, psychedelic-induced vasoconstriction reduces brain flow all across the brain. Which would reduce BOLD signals across the board. Does that not make BOLD signals caused by psychedelics even more significant, because we are filtering out the more subtle changes?

PS: We still recommend you use 1 R2drive per silicon probe, which can be then used for multiple implantations.

a man wearing an iron & kin sweatshirt stands in front of a wooden table ALT: a man wearing an iron & kin sweatshirt stands in front of a wooden table

And we record the video, so that we can trace all the R2drives we ship. As a result, we can learn more about the life cycle of our R2drives in your labs. And improve user support.

Shuttle movement is evaluated from 2 angles, to ensure smoothness of the drive mechanism (there is always some 'wiggle' due to manufacturing imperfections of the guiding screw).

📣 R2drive now comes with a serial number. This enables individual, traceable, quality control.

Well, a sliver of fun on an otherwise rough situation.

Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take…

A statistical error known as pseudoreplication appears in more than half of recent mouse studies on neurological disorders, according to a new study. Peter Kind and Constantino Elfetheriou tell Lauren Schenkman why researchers should pay attention.

www.thetransmitter.org/pseudoreplic...

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025

Kilosort4 detects a LOT of neurons, I recorded 15k neurons in one year 🤯 Traditionally, one would curate these detected units to see if they are well isolated single neurons. This is not feasible anymore, so today let's look at three options that are out there to automate this process! 🤖👇

Reviewer 2 really has us blushing (and slightly bragging ;) ) on this one! 🙏 If you want to check out the MOST WELL-WRITTEN AND WELL-VIDEOGRAPHED protocol on chronic electrode implants in mice, head over here:
app.jove.com/t/66867/the-...

@3dneuro.bsky.social @openbehavior.bsky.social

⏰ Last days to apply!!⏰

This hands-on course covers:
🦠 Flies/Zebrafish – Optogenetics, 2P imaging
🐭 Mice – 2P/3P imaging, Neuropixels, closed-loop behavior

📅 June 8-27, 2025 | Champalimaud, Lisbon
⏳ Apply by March 7
🔗 loom.ly/OMvqMcE

Just found out @DeepLabCut was downloaded 832K times! Wild.

After scrolling through 20 posts about NIH funding, this brought some much needed relief 😅

Join us in the following programs that demystify cutting-edge neuroscience techniques and empower you with low-cost, open-source tools you can use 🧠⚡️

More info in the thread below 👇

#OpenEphys #OEdu #ExperimentalNeuroscience #BehavioralNeuroscience

Thanks for the shout-out! 🙏

The DREAM implant is a novel design for chronic electrophysiology in mice that is lightweight, adaptable, and cost-effective. @ZeroNoiseLab @3DNeuro @DondersInstitute

Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...

I hate the direction lab equipment design has gone in recent years.

I don't want touchscreens, I don't want wifi integration, I don't want centrifuges demanding to know what time zone they're in.

I just want reliable instruments - with physical buttons - that do the one task they were made for.

Nice study! Any plans to try out awake scanning in future? We're currently helping a couple labs establish awake headfixed rat scanning. It's still early days (no papers yet), feel free to get in touch if interested

We're closing the R2np preorder campaign!! Based on the response, this holder for Neuropixels 2.0 probes with dovetail will become a product in 2025 as a special version of the R2Drive! #opensource #openhardware

Where do we stand on fMRI in awake mice? Abstract. Imaging awake animals is quickly gaining traction in neuroscience as it offers a means to eliminate the confounding effects of anesthesia, diffic

Fantastic review on awake rodent fMRI academic.oup.com/cercor/artic... by @grandjeanlab.bsky.social and coll. #neuroscience #neuroskyence

Hopping around 🦋

Hi! We are 3Dneuro - a small band of neuroscientists who hunted spikes in behaving animals for years before saying: This has to be easier! We design electrode drives, implant systems and behaviour setups that are robust, easy to use, and open-source. Or: Ephys for everyone! Check us out: 3dneuro.com

How to rebuild your network on @bsky.app and improve your experience here?

I made a short starter guide with resources.
www.neuronaldynamics.eu/resources/bl...

Also, a thread 🧵 below.

New to Bluesky, we were supposed to first write an introduction post. Enjoying unfiltered content instead.

Hello, 🦋. Heard there's some #neuroscience #neuroskyence #opensource #openhardware going on over here