#PCBCommunity |🧫El @cnag-eu.bsky.social cartografia el conjunt més complet de dominis proteics en retrovirus endògens humans.🔬L'estudi liderat per @annaesteveco.bsky.social amb @idibell.bsky.social ha identificat 17.540 dominis proteics retrovirals en les seqüències HERV.
👉 https://tuit.cat/125qv
🚀 New paper out in NAR Genomics and Bioinformatics!
👉 CNAG maps the most complete set of protein domains in human endogenous retroviruses
@annaesteveco.bsky.social & @tmontsay.bsky.social analysed 120K ORFs derived from HERVs, identifying 17K retroviral protein domains
www.cnag.eu/news/cnag-ma...
🙌 What a great day at #Transfiere2026!
This week, our Clinical Genomics Manager at CNAG, @lmatalonga.bsky.social, took part in the roundtable “Biomedicine-IMPaCT and Prevention” alongside @saludisciii.bsky.social, @sanidad.gob.es, and @farmaindustria.bsky.social
#ICTS #ICTSNews #IMPACT #CNAG
💜CNAG Lights Up For Rare
Tomorrow it's #RareDiseasesDay, a day to raise awareness of the 300 million people living with rare diseases worldwide
At CNAG, we improve diagnosis through genomics and help families find answers
#LightUpForRare @rarediseaseday.bsky.social @erdera.bsky.social #rarediseases
#RareDiseaseDay is an opportunity to recognise the 30 million people in Europe living with a rare disease. As a partner in @erdera.bsky.social, we're working together to advance prevention, diagnosis, and treatment
Proud to be part of a community making more impact than you can imagine 🤝
🚀 A new #BreastCancer project takes off: HER-CARE!
🩷 A doctoral training programme on Hereditary and Early-onset breast cancer
🎯 Our role: determine how germline and somatic variants affect protein structure, using an AI-based classifier to analyse them
📎 www.cnag.eu/projects/her...
#CancerdeMama
🙌¡Qué gran día en #Transfiere2026!
Ayer, nuestra Responsable de Genómica Clínica en Centro Nacional de Análisis Genómico, @lmatalonga.bsky.social, participó en la mesa redonda “Biomedicina-IMPaCT y prevención” junto a @saludisciii.bsky.social, @sanidad.gob.es y @farmaindustria.bsky.social
@Fycma
🚨Call for Abstracts and Registration Open!
Join us at the European Society for Spatial Biology Conference - Painting a New Biology!
🗓️September 28th to October 1st, 2026
📍Hotel Melià Sitges (Barcelona, Spain)
👉Organised with the support of CNAG (@pascual-reguant.bsky.social)
essb2026.org
#essb
💫The study, led by CNAG, @cabd-upo-csic.bsky.social and the Duke University Medical Center, is a further step to understand non-coding regulatory regions and 3D hubs that coordinate gene expression, laying the foundation for more precise genome engineering and modification of gene expression
24.02.2026 10:21 — 👍 0 🔁 0 💬 0 📌 0
5️⃣ 𝘈𝘱𝘱𝘭𝘪𝘤𝘢𝘵𝘪𝘰𝘯𝘴
These findings show how the same gene can play distinct roles in different tissues, as illustrated in mammalian sex determination. They also provide a foundation to better understand a group of conditions, such as Differences of Sex Development (DSD)
#RealApplications #HumanHealth
4️⃣ 𝘛𝘩𝘦 𝘳𝘦𝘴𝘶𝘭𝘵𝘴
Using the geostatistics-inspired method, researchers identified a novel regulatory region controlling Fgf9, a key gene downstream of Sry that activates Sox9 and triggers testis development, as well as new regulatory networks including the Meis1 and Meis2 genes
#Computational #Biology
3️⃣ 𝘛𝘩𝘦 𝘮𝘢𝘫𝘰𝘳 𝘤𝘩𝘢𝘭𝘭𝘦𝘯𝘨𝘦
To decode this vital process, CNAG developed 𝘔𝘌𝘛𝘈𝘓𝘰𝘤𝘪, a powerful predictive method that brings together a comprehensive and unified view of multiple genomic sites that had remained hidden, identifying 3D regulatory hubs and mapping gene regulation across cell types
2️⃣ 𝘛𝘩𝘦 𝘧𝘪𝘳𝘴𝘵 𝘴𝘵𝘦𝘱
To provide new answers to these questions, researchers began by obtaining the tiny gonadal cell populations before and after sex determination. Surprisingly, even using Hi-C and ChIP-seq, only minimal 3D chromatin changes were observed
#3DGenome #Nature #Research #HiC #ChIPSeq
1️⃣ 𝘛𝘩𝘦 𝘤𝘰𝘯𝘵𝘦𝘹𝘵
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process
#CNAG #StructuralGenomics #SexDetermination
🚀 New paper out in @natsmb.nature.com!
🔝Dr @mamartirenom.bsky.social (Structural Genomics Group Leader at CNAG and CRG) and Dr Juan Antonio Rodríguez launch 𝗠𝗘𝗧𝗔𝗟𝗼𝗰𝗶, a novel computational framework that reveals the 3D mechanisms of sex determination in mammals
📎 www.cnag.eu/news/metaloc...
💫 Excited to welcome Lluís Solà as the new General Manager of CNAG!
🔝With over 2 decades of experience in research, innovation, and leadership, he will contribute to strengthening our impact on international genomics and research excellence
Our warmest welcome, Lluís!
📎 www.cnag.eu/news/llu%C3%...
✈️ De camino a #Transfiere 2026!
🗣️ Nuestra Responsable de Genómica Clínica en CNAG, @lmatalonga.bsky.social, participará en la mesa redonda 'Biomedicina - IMPaCT y prevención' junto con @saludisciii.bsky.social, @sanidad.gob.es y @farmaindustria.bsky.social
🗓️ Martes 24/02 🕐14:35h
#ForoTransfiere
🗣️Ayer, nuestro Jefe del Grupo de Genómica de Célula Única en CNAG, @hoheyn.bsky.social, participaba en la Conferencia 'Ómicas de célula única y el Atlas Celular Humano', organizada por la @fundacionareces.bsky.social y @springernature.com
📎 www.youtube.com/live/qF0jcQv...
#frAreces #genomica
🙌 Our first year of @easigen-eu.bsky.social, what an important milestone!
Really excited to be behind this challenging project, which aims to design a European genomic infrastructure to bring the benefits of genomics to all countries on the continent
💙 Together, we are going to make it possible!
🗓️ Free webinar: “Streamlining Tumour Interpretation with the Cancer Genome Interpreter (CGI)”
🕐 9 April 2026, 14:00–15:30 CET
Organised by the @cgiclinics.bsky.social project, aimed at advancing personalised oncology across Europe. CNAG is one of the partners in this initiative.
More information ⬇️
👀 Curious about what we’re doing in immune-mediated inflammatory diseases across Europe?
📹 Watch this presentation by our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, under the umbrella of the DOCTIS Project ⬇️
📎 doctis.eu/relive-docti...
#IMIDResearch #AutoimmuneTherapies
🆕 Preprint: Standardized transcriptome analysis boosts rare disease diagnosis in the pan-European Solve-RD consortium
🙌 Using a harmonized RNA-seq analysis, 19 families got a molecular diagnosis
With @annaesteveco.bsky.social, @vyepez.bsky.social, Julien Gagneur
www.medrxiv.org/content/10.6...
🚀 New reference genome!
🪱 This time, for the milky worm endemic to the Pyrenees
🧬 The CNAG team sequenced the genome and carried out its assembly, curation, and annotation within the framework of @ergabiodiv.bsky.social & @biogeneurope.bsky.social
📎 open-research-europe.ec.europa.eu/articles/6-26
Photo Credit: Marta Moreiras.
🙌 𝗖𝗡𝗔𝗚 𝗶𝘀 𝗻𝗼𝘄 𝗮 𝗺𝗲𝗺𝗯𝗲𝗿 𝗼𝗳 𝘁𝗵𝗲 𝗖𝗹𝘂𝘀𝘁𝗲𝗿 𝗼𝗳 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗘𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 – 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀 𝗳𝗼𝗿 𝗛𝗲𝗮𝗹𝘁𝗵 𝗶𝗻 𝗔𝗳𝗿𝗶𝗰𝗮 (𝗖𝗼𝗥𝗘-𝗚𝗛𝗔)!
🌍 We are excited to contribute to harnessing the power of genomics to transform healthcare across Africa through our membership, led by Pedro Rodríguez (CNAG)
📎 www.cnag.eu/news/cnag-be...
Last Friday we had the pleasure of hosting Dr Marc Martí-Renom @mamartirenom.bsky.social from @cnag-eu.bsky.social & @crg.eu at our #SeminarsIN with his talk: “4D Nucleomics, advances in genome structure analysis”
Fantastic lecture, thank you! 👏
@barcolab.bsky.social @csic.es @dicv.csic.es @umh.es
Fátima Al-Shahrour, líder de la @bioinformatics.cnio.es, interviene en la mesa redonda 'Bioinformática e inteligencia artificial en la era de la genómica' en la conmemoración del 25 aniversario del Proyecto Genoma Humano en @cnag-eu.bsky.social
10.02.2026 12:57 — 👍 4 🔁 2 💬 0 📌 0
👉 @irbbarcelona.org i @cnag-eu.bsky.social descobreixen el mecanisme que explica la resistència d'alguns càncers colorectals a l'oncogen KRAS
04.02.2026 10:24 — 👍 4 🔁 2 💬 1 📌 0🗞️A study published in @naturemedicine.bsky.social and led by #ICREAresearcher Holger Heyn ( @hoheyn.bsky.social @cnag-eu.bsky.social ) expands the current knowledge of inflammation biology and creates a framework for classifying inflammatory diseases.
05.02.2026 08:13 — 👍 2 🔁 2 💬 0 📌 0
🙌5th @hereditaryeu.bsky.social Meeting!
In our 3rd year, we are making strong progress in federated learning and analytics, advancing privacy-preserving multimodal health data analysis across Europe
🧬Proud that CNAG contributes to this European Project
#HorizonEurope #HereditaryCancer #CNAG
🚨Job Alert!
Join us and be part of our cutting-edge genomics centre:
Our current openings:
👉 Head of Finance
👉 Accounting Manager
👉 People Officer
👉 PhD Computational Biologist
👉 PhD/Postdoc Fellowship 2026
👉 Lab Facilities Support Assistant
📎 www.cnag.eu/jobs
#CNAG #Jobs #Empleo #Barcelona
