Dina Grohmann

I like to show the evolution of this classification to the students to highlight the fantastic bioinformatics work of Kira and Eugene and co-authors but also to illustrate the rapid development in the field ☺️.

True!

Heute noch mal

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

I naturally only highlighted the archaeal aspects but there is so much more. Enjoy delving into this comprehensive story with a ton of data in it. Shoutout also to the Santangelo and Ferreira-Cerca labs that contributed to the archaeal side of things alongside the Grohmann lab. (3/3)

Massive team effort led by RNA modification guru Schragi Schwartz. Happy that the Grohmann lab could contribute in showing that dynamic rRNA modifications in hyperthermophiles are common & tightly regulated by temperature, with about half of all rRNA modifications changing in response to heat. (2/3)

Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing modifications to support...

How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)

Job advertisement

We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...

ribosomologists take note 👇

archaeal ribosome hibernation factors aRDF, Dri, ...and now: Hib (see ALT)
#Archaea #ArchaeaSky

Are you interested in Biomolecular Condensates and looking for a PhD training? Check out the 12 (!) open PhD positions (also 1 on smFRET & condensates 🙃) in Dresden @rtg3120.bsky.social @tudresden.bsky.social starting April 2026. Apply latest by 24 Oct 2025 here: dresdencondensates.org/join-us/

You can get MSAs directly from AlphaFold DB now (alphafold.ebi.ac.uk). I also missed the FoldSeek implementation, which lets you search for structurally similar proteins direktly.

This saves some clicking around. Neat!

Thank you Jane Goodall for EVERY SINGLE SENTENCE in this interview to remind us of what is important and to encourage us to never loose hope and to try to make a difference everyday of our life 🤝🫶!!!

YouTube video by National Geographic Official Film Trailer: JANE | National Geographic

"Jane" (2017), directed by Brett Morgen, with music by Philip Glass, and based on unseen footage discovered shortly before, is one of the most enchanting films I've ever seen. Goodbye Jane Goodall, and thank you.

www.youtube.com/watch?v=FRlU...

The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...

Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...

Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins - Nature Communications Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.

Biogenesis and function of archaeal lipoproteins.

This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.

www.nature.com/articles/s41...

Mir geht das des Öfteren auch so … werden wir alt 😅?? Und viel Spaß in Nürnberg! Schaust Du auch mal bei uns in Regensburg vorbei?

Find up to date links to the Farnung lab's cloning, experiment designer, and buffer preparation software tools here: www.farnunglab.com/tools

Interested in removing particle-associated microbes from particles for eg flow cytometry, culturing, or other single-cell microbiology purposes? Led by graduating PhD stdnt Jordan Coelho:

Detergent-based separation of microbes from marine particles journals.asm.org/doi/10.1128/... #jcampubs 🌊

#FEMSmicroBlog: Halophile archaea healing themselves This #FEMSmicroBlog explains how the halophile model organism Haloferax volcanii repairs DNA double strand breaks quickly and efficiently. #FascinatingMicrobes

To maintain genome integrity, extreme organisms like archaea rely heavily on repair pathways.

This #FEMSmicroBlog explains how the halophile model organism Haloferax volcanii repairs DNA double strand breaks quickly and efficiently. #FascinatingMicrobes

new Lai lab #miRNA paper alert!! happy to share Renfu Shang's mechanistic insights into the mysteries of miRNA cluster assistance. wonderful collab with Niko Popitsch and @ameressl.bsky.social

🧵 later, but if you don't know this process, my daughter illustrated it.🧬

www.biorxiv.org/content/10.1...

Collections Online store and information hub for the street art of ephemeral sidewalk chalk artist David Zinn, known for his cheerful 3D (three-dimensional) creatures including the stalk-eyed monster Sluggo, flyi...

Thank you for finding me here! I try to post new art every couple of days. My original works are temporary street art, but you can buy prints, books, calendars and postcards of their images at zinnart.com/store. Cheers!

Another great story from the Albers lab @archaellum.bsky.social 👍!! Congrats to all authors … exciting science ☺️!!! But how shall we name the motility structures now that archaellum is not exclusively reserved for Archaea any longer 😳??

Archaeal Virus Ph.D. project! (With Tessa Quax)
www.rug.nl/about-ug/wor...

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

YouTube video by Exciting Instruments What is single-molecule FRET?

What is single-molecule FRET? Watch
@timcraggs.bsky.social
explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET

EvoChromo: Evolutionary approaches to research in chromatin Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

3rd Argonaute Conference successfully concludes · AGO 3rd International Argonaute Syndromes Conference in Prague, Czech Republic, and online, was another truly life-changing, inspiring, and emotional event

Read more: argonautes.ngo/en/news/3rd-...

The Argonaute band rocked big time and indeed brought a lot of joy 🤩 ☺️! Thanks again guys!!