Dan Jones

Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5 PP2A serine/threonine phosphatases are heterotrimeric complexes that execute many essential physiologic functions. These activities are modulated by a…

Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors!

www.sciencedirect.com/science/arti...

09.04.2025 15:29 — 👍 6    🔁 1    💬 0    📌 0

Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity Protein phosphatases are dynamic enzymes that exhibit complex regulatory mechanisms, with disruptions in these regulatory processes associated with di…

Great to see our work on protein phosphatase 2A (PP2A) and IER5 featured in a recent review by Peti and Page labs. Particular focus on our work identifying structural homology between IER and SRTD proteins using a conserved alpha helical hairpin motif. www.sciencedirect.com/science/arti...

27.02.2025 13:07 — 👍 0    🔁 0    💬 0    📌 0

Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.

11.02.2025 01:30 — 👍 43    🔁 27    💬 3    📌 2

Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍

Shimakawa et al:
www.cell.com/cell/fulltex...

Nam et al:
www.cell.com/cell/fulltex...

@biozentrum.bsky.social press release:
www.biozentrum.unibas.ch/news/detail/...

Read on for more...
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29.11.2024 15:17 — 👍 239    🔁 65    💬 7    📌 6

Yes please!

25.11.2024 00:54 — 👍 1    🔁 0    💬 1    📌 0

Diving into Rosetta this Sunday morning with a mutation scan and a coffee.

24.11.2024 15:25 — 👍 0    🔁 0    💬 0    📌 0

It’s nice to have a feed filled with science rather than all that other stuff. Hope it stays that way.

17.11.2024 23:02 — 👍 0    🔁 0    💬 0    📌 0

Earlier this year we published functional profiles of all 33 adhesion GPCRs in signalling/biosensor assays. Led by recently graduated Drew Dates, we found a dichotomy of tethered agonist dependent and independent receptors.
www.sciencedirect.com/science/arti...

17.11.2024 20:14 — 👍 3    🔁 1    💬 0    📌 0

Our recent story on the mechanism of PP2A/B55 inhibition by IER5 - a notch target gene essential for keratinocyte differentiation in squamous cell carcinoma cells. We use functional assays, biochemistry and Cryo-EM to determine the molecular mechanism www.biorxiv.org/content/10.1...

17.11.2024 20:03 — 👍 2    🔁 0    💬 0    📌 0