Samuel A. Myers' lab

A good core won't need or use bsa in sheath fluid. Most don't. I was disabused of the need for bsa early on.
PMID: 30792265

Damn @lucasbsullivan.bsky.social you made the first version of a starter pack? Im jellyyyy

This is what studying O-GlcNAc feels like, w/ @lucasbsullivan.bsky.social #glycotime

SP3/PAC beads or
3kDa MWCO filters or
Protein precipitation or
Desalting columns or
Use less biotin and wash the cells more

A druggable redox switch on SHP1 controls macrophage inflammation https://www.biorxiv.org/content/10.64898/2026.02.19.706790v1

New preprint!

TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses

www.biorxiv.org/content/10.6...

To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607

I’m recruiting new members to the Farrell Lab this summer. We will have space for 1 postdoc (since Abhinav is leaving to start his own lab at U Arizona!!) and 2 postbacs, since my current two will leave for PhD programs at the end of the summer. More details in thread:

Wait til you see Southern California driving.

Please 🔁

My group at UBC received an allocation from the school to apply for the Canada Impact+ Training Awards (postdoc). Everything is moving fast but please email me in 48 hours with a CV if you are outside Canada and interested😎
Yachie lab: yachie-lab.org
sshrc-crsh.canada.ca/en/funding/o...

Has anyone tried hiding text in grants and manuscripts that tell AI readers this is great work? Asking for a friend....

Yusssss

"Except it doesn't bend on it's own. It's because we pull it in the direction of justice." Obama.

You can't think out of the box if you don't think. For how i see it this is not an inherent problem of AI, which at the end it's just at tool (for now). It's rather a problem inherent to us, human beings (aka lazy bastards).

Come join next week @lji.org!

Whoa

cool

Happy #MassSpecMonday!
Explain mass spectrometry badly in one sentence.

We’ll start: “Yeet molecules into a vacuum and see who panics first.”
Your turn 👇

#ASMS #TeamMassSpec #MassSpecCommunity

Coaches don't play

@gottschalklab.bsky.social what's that graphic remind you of?
PMID: 35063833

The best thing one can do for technicians who want to go to graduate school is to teach them how to plan an experiment properly. Maybe even full project considerations. They come in so much stronger.

jealous

Lab holiday dinner. Delightful all around. @samyers-lab.bsky.social @lji.org #blessed

cool

Ah yes, the canine cat.

You betcha. And you're probably looking at extracellular domains so you probably don't have to worry about phospho like the other guy mentioned. That's for intracellular OGlcNAc.

BEMAD?

He forgot to mention how I sparked his love for mass spectrometry ;)

Imagine training for years or even decades to critically analyze and interpret data and graphs and then just having some program summarize a paper based on whatever the authors have written. Crazy.

@seth-shipman.bsky.social does it again.