Valerio Sorichetti

Amazing colloquium talk by Christa Schleper from @univie.ac.at @archaea-vienna.bsky.social on how archaea use protrusion to crawl on surfaces!

#archaea #loki
@istaresearch.bsky.social

Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota) Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways1–3. Asgard archaea (phylum Promethearchae...

Asgard on the move ! Watch our videos!
Biorxiv.org/content/10.1101/2025.11.30.690169v1

From the point of view of how we conduct our day-to-day work, I definitely agree. But we are also, technically, building a model described by equations and then solving (using a computer) these equations.

theorist. I think it's quite interesting, I've discussed it with colleagues doing agent-based simulations and analytical theory and some seem to consider the first aspect more important, whereas others focus on the second one. 2/2

Yes, that's an important distinction and I agree with you. However, even when doing agent-based simulations, I think that while the day-to-day work is very close to that of an experimentalist, conceptually one is still solving equations, which makes it close to the work of an analytical 1/2

Something I was recently discussing with some colleagues: is the work of computational scientists closer to the one of experimentalists or to the one of theorists working on analytical models?

I tried it -- very impressive!

A caveat, however -- it might make you feel as if your published papers aren't as good as you thought 😅

Temporal and spatial coordination of DNA segregation and cell division in an archaeon | PNAS Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segre...

Our paper on chromosome segregation in the archaeon Sulfolobus Acidocaldarius has been published in PNAS! This has been a great collaboration with @joeparham19.bsky.social and the rest of @buzzbaum.bsky.social's team. Stay tuned for more to come!😉 @istaresearch.bsky.social

doi.org/10.1073/pnas...

Just noticed a mistake in the paper reference in the slide: the last two authors should be Šaric and Baum, not vice versa!

Grateful for this opportunity of taking part in the 9th International Soft Matter Conference in beautiful Crete and presenting my research! It's been a great week of science, stimulating discussions and great food in a beautiful scenery 😊🏖️

It has been a great workshop! Thanks to @romanstano.bsky.social, Peter, Emanuela and Christos for giving me the opportunity to present my work :)

Super excited that our group will be supported by an ERC Starting Grant!

In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.

We'll have PhD and Postdoc positions available, please get in touch if interested!

Huge congrats!! 👏🏼👏🏼👏🏼 Super well deserved!

I know two of the authors, this paper was a huge hit in the media 😁

@istaresearch.bsky.social

@istaresearch.bsky.social

Nonequilibrium Remodeling of Collagen IV Networks in Silico Active bond remodeling enables collagen IV networks to have a range of responses to strain while maintaining their mechanical integrity.

Our paper on the nonequilibrium mechanics and remodelling of collagen-IV networks is finally out on @prxlife.bsky.social! It has been a long and exciting scientific journey, led by @billiemeadowcroft.bsky.social! @ivnpla.bsky.social @yanlanmao.bsky.social

journals.aps.org/prxlife/abst...

Sally Rooney books are kinda neat until you read a couple and realize that all the plots and characters are exactly the same...

Sass de Putia, Dolomites!

Of course! Maybe we can even meet there, that would be great :)

The Dolomites really are a special place. Very lucky to have had so many days of great weather! ⛰️🥾

A stambecco (ibex) with her baby 🐐

Scientific curiosity at IMBA inspired this year's art series, created from research images. Today's kaleidoscope is based on an artistic rendering of the spiral staircase model of the mitotic chromosome, produced by the Goloborodko lab using new tools for analyzing 3D chromosome structure.

And it's finally published on @prxlife.bsky.social! Thanks to Paul Robin (Hannezo lab) , @ivnpla.bsky.social (Šaric lab), @aharmendariz.bsky.social (Cuylen lab). It's been a very stimulating and highly satisfying journey! 🧬

journals.aps.org/prxlife/abst...

Sass dla Crusc in the Dolomites 😊

So satisfying when the last round of proofs for your paper comes back the day before you leave for vacation! 😊

Is it just me or Google search results got significantly worse recently?

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

Wow!! This is super cool!

5-panel comic. (1) [teacher with long hair next to whiteboard] TEACHER: I’m supposed to give you the tools to do good science. (2) [teacher addressing students] But what *are* those tools? Methodology is hard and there are so many ways to get incorrect results. What is the magic ingredient that makes for good science? (3) TEACHER: To figure it out, I ran a regression with all the factors people say are important: [embedded list in sub-panel, cut off at end] Outcome variable: correct scientific results. Predictors: collaboration; skepticism of others’ claims; questioning your own beliefs; trying to falsify hypotheses; checking citations; statistical rigor; blinded analysis; financial disclosure; open data (4) TEACHER: The regression says two ingredients are the most crucial: 1) genuine curiosity about the answer to a question, and 2) ammonium hydroxide. (5) STUDENT: Wait, why did *ammonia* score so high? How did it even get on the list? LONG HAIR: ...And now you’re doing good science!

Good Science

xkcd.com/3101/