Stephen O'Rahilly

Pre-pregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum Severe nausea and vomiting of pregnancy and hyperemesis gravidarum are associated with adverse maternal, fetal, and child outcomes. The recurrence ris…

sciencedirect.com/science/arti... Great to see further evidence emerging supporting the pressing need for trials of preconceptional GDF15 desensitisation with metformin for prevention of severe nausea and vomiting of pregnancy in women with a previous history. Congrats to @drfejzo.bsky.social

Opinion | How the Gay Rights Movement Radicalized, and Lost Its Way

www.nytimes.com/2025/06/26/o... Amazing to see this article appear in the NYT. I hope many of my fellow endocrinologists are reading it @endocrinesociety.bsky.social

OMG. This looks terrifying.

Mice lacking this amino acid lost 30% of their body weight But eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

I did start my talk by showing the photo and saying (with a wry smile, of course) how delighted I was to be in Uppsala….

Had a great time at Lund university attending their Spring Meeting. Amused to see this poster outside the lecture theatre. Those old English universities: it’s hard to tell them apart 😊

Graphic of medicines on a blue background

📢 Job Vacancy! Institute of Metabolic Science
@ims-mrl.bsky.social are looking for a Research Nurse to join their team. Applications open until 30th May!

>>> For more info: bit.ly/4iIkrNo

@cuhnhs.bsky.social @mrcepid.bsky.social @stephenorahilly.bsky.social @cambridgeuni.bsky.social

Indeed. And so ironic that while the new administration says it is very keen to understand the effects of food on health, their actions are resulting in the closure of one the US’s most effective labs in that area @kevinh-phd.bsky.social

Carole Hooven: Why I Left Harvard After I stated banal facts about human biology, I found myself caught in a DEI web, without the support to do the job I loved. The only way out was to leave it.

www.thefp.com/p/carole-hoo.... While I applaud Harvard for standing up to the Trump government, this article is mandatory reading for anyone who doesn’t understand how it got to this point.

UK’s supreme court rules that legal definition of woman is based on biological sex. This is a hugely important decision. Unanimous .I hope it will open up rational debate in other countries.

Thanks so much Brent. I hope I made it clear in my talk that the discovery of the role of GDF15 in pregnancy sickness was very much an international collaborative effort

I really enjoyed recording one of these with you several years ago. Wishing you well with whatever your next venture will be.

Almut Gadow v Open University Almut Gadow Dr Almut Gadow has a personality similar to those I’ve stumbled across a lot whilst talking to people about gender ideology. She’s fiercely intelligent, does not back down a…

Almut Gadow v Open University genderblog.net/almut-gadow-... This piece is from Nick Wallis, the journalist whose doigged research exposed the Post Office Scandal. He is now taking a serious interest in an area that is increasingly affecting UK universities.Worth a read

Come and study with us for a Masters!

Shahrar Ali on X: "Fiery speech @ChrisDaviesLD pulling no punches, calling out impact upon impressionable youth of sex denialism, unfettered social contagion & failure of medical due diligence. Truth will cut through in end, once we've properly dispensed with no debate. https://t.co/SlXvgnn4mx" / X Fiery speech @ChrisDaviesLD pulling no punches, calling out impact upon impressionable youth of sex denialism, unfettered social contagion & failure of medical due diligence. Truth will cut through in end, once we've properly dispensed with no debate. https://t.co/SlXvgnn4mx

x.com/shahrarali/s...

The Observer view on gender data: failure to accurately record biological sex harms us all | Observer editorial A report lays bare the extent of real-world detriment caused by institutions that have caved in to activist pressures

www.theguardian.com/commentisfre...

The absence of data on biological sex is an affront to reality The 226-page report into how official data on sex and gender is recorded, by Professor Alice Sullivan of University College London, exposes shocking gaps in public records due to confusion between

The absence of data on biological sex is an affront to reality

www.thetimes.com/article/7463...

Sorry. That should be the Berthold Lecture!

Honoured to be in Baden-Baden to receive the Berthold Medal from the German Endocrine Society and give the abet gold lecture. Really great questions from a wonderfully engaged and responsive audience. Thanks to #JensBruining for his very kind introduction.

Sex Matters on X: "“Everybody, regardless of their politics, needs accurate data.” @ProfAliceS speaks to @JustinOnWeb @BBCr4today about the #SullivanReview 📻 https://t.co/BSR8ls60pP" / X “Everybody, regardless of their politics, needs accurate data.” @ProfAliceS speaks to @JustinOnWeb @BBCr4today about the #SullivanReview 📻 https://t.co/BSR8ls60pP

x.com/sexmattersor...

This International Women's Day, we celebrate as women advocate for change, equity, & inclusivity paving the way for future generations of women scientists

Meet Agnes Lukasik, Patient and Public Involvement & Engagement Manager @ims-mrl.bsky.social

#IWD2025 #AccelerateAction

@mrcepid.bsky.social

Pretty much any bit of useful science I have ever done has involved focusing on the outliers! Each to their own!

Ghastly as the tech bros are, and crude the tools they are using to seek out research they don’t approve of, the most organised efforts to expunge the words “female” and “woman” from sci pubs have actually been made by some of our “leftybro” friends in their ill-judged attempts to be inclusive.

Final Report – Cass Review

cass.independent-review.uk/home/publica.... This article reveals how and why that happened at @nejm.org. In no other area of medicine would the conflict of interest revealed been allowed, or at least allowed to remain undeclared

The Corruption of The New England Journal of Medicine A leading medical journal has capitulated to transgender activists.

www.city-journal.org/article/new-... I was shocked when a recent Perspective in @NEJM disregarded the most thorough, unbiased, science-based assessment of the risk/benefits of taking a pharamacological approach to minors asking for help in relation to their biological sex/

adiposetissue.org: A knowledge portal integrating clinical and experim... www.sciencedirect.com/science/arti... Thanks to the authors for providing a great online tool for the community

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity - Nature Communications Systemic lipid homeostasis requires hepatic autophagy to recycle intracellular fat. Here, the authors identify peripheral mechanisms regulating energy homeostasis, showing that MC3R is a regulator of ...

www.nature.com/articles/s41.... Interesting but report of liver autonomous effects of MC3R a bit surprising given the very low expression of MC3R in liver, at least in humans

Senate confirms Robert F. Kennedy Jr., a vaccine opponent, as health secretary Controversial attorney will oversee vast health research and drug safety programs

www.science.org/content/arti... Unless he radically changes his approach, which seems unliely, this could be very bad news for US public health and biomedical science. He is actvely campaiigning againsyt HPV vaccination which is abolishing cervical cancer and mainatining an excellent safety record

see nationally commissioned and extremely rigorous Cass Report ( cass.independent-review.uk/home/publica...)

Advancing Transgender Health amid Rising Policy Threats | NEJM The current U.S. political landscape poses escalating challenges for transgender health. Clinicians, researchers, policymakers, and advocates can act to counteract regressive policies.

www.nejm.org/doi/full/10.... . States that gender affirming care (incl puberty blockers and cross-sex hormones in minors) is "essential, evidence-based, and often lifesaving". In no other field would the @NEJM advocate for therapies with such a weak evidence base.