Osman Lab

Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• PS1 in inner membrane regulates cristae & mtDNA stability 🧬
• MitoMetrics refines forensic likelihood ratios
• SMC loss linked to MELAS dysmotility 🔬
#Genetics

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Daily mtDNA Research Briefing Header

Daily #mtDNA intel: • Most axonal mitochondria lack mtDNA/ATP 🧬 • ROS impairs lysosomal flux in human APOE4 cells • Mitogenome variants impact Parkinson's progression 🔬 #Neuro

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Daily #mtDNA intel: • Fumarate loss activates cGAS-STING 🧬 • MT-CO2 m.8024G>A drives bioenergetic failure • mtDNA background impacts pS65-Ub in Lewy body disease 🔬 #genetics

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Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• C24-Ceramide-VDAC1 binding triggers hypoxic mtDNA release 🧬
• TFAM roles mapped across pan-cancer types
• Melatonin identified as a mitochondrial radioprotectant 🔬

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Daily #mtDNA intel: • Liver mitochondria drive systemic inter-organ aging 🧬 • cGAS-STING blockade preserves tendon stem cell fitness • ZBP1 promotes RIPK1-dependent apoptosis

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Agreed, the engagement seems rather low to me as well

#C.elegans is about to join the 'centriolar satellites' club. Check out our new preprint #centriolarsatellites: www.biorxiv.org/content/10.6...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• MAF1 inhibits AIM2 by sequestering host mtDNA 🧬
• Cytoskeleton loss dysfunctions B-ALL mitochondria
• LRRK2 G2019S drives oxidative DNA damage 🔬
#CellBio #Genetics

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Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 Nature Structural & Molecular Biology, Published online: 27 February 2026; doi:10.1038/s41594-026-01756-0Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.

New online: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15

Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• APOL3 mediates mtDNA efflux via lysosomal damage
• ALS blood/CSF mtDNA indices profiled 🧬
• CRISPR-guided biogenesis in iPSC-CMs 🔬

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Daily #mtDNA intel: • TFAM replication vital for oocyte competence 🧬 • Hypoxia triggers APOBEC3A-mediated DNA damage • Aging reduces muscle resilience after disuse #MitoSci

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Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• PRMT5 regulates stability via TFAM methylation 🧬
• Leakage triggers cGAS-STING neuroinflammation
• Mitophagy failure promotes release in selenium deficiency 🔬

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Daily #mtDNA intel: • 4,5-DHA validated as robust disease marker • Single-cell lineage tracing via inheritance modeling • ROS quenching suppresses cGAS-STING signaling 🧬🔬

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Check out today's mtDNA research briefing!

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Daily #mtDNA intel: • Cardiospecific POLG loss drives cardiomyopathy 🧬 • EV-mediated mtDNA transfer triggers osteoarthritis • Gstk1 inhibits cGAS/STING in sepsis 🔬 #genetics

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Rapid directed evolution guided by protein language models and epistatic interactions Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...

www.science.org/doi/10.1126/...

Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...

This argues against the hydrogen hypothesis of mitochondrial origin. 👇
www.nature.com/articles/s41...

See also this excellent context (including a microscopy 🔬movie of crawling Asgards) by @carlzimmer.com:
www.nytimes.com/2026/02/18/s...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel: • Single-cell lineage tracing via inheritance 🧬 • USP10-MTX2 axis regulates cGAS-STING signaling • EV mtDNA transfers drive osteoarthritis 🔬

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A pilot in a submersible vehicle collecting sediments samples in 30 meters of water looking for Asgards (microbial relatives of eukaryotes)

One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22

We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!

More about us: martinottlab.com

Apply here:
web103.reachmee.com/ext/I005/103...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel: • Mito transfer fuels tumor pyrimidine synthesis 🧬 • mtDNA dsRNA drives aging-associated cognitive decline • Novel 12244G>A variant linked to MELAS phenotype 🔬

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New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1.
www.biorxiv.org/content/bior...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel: • dsRNA drives aging-linked cognitive decline 🧬 • EV mtDNA transfer triggers osteoarthritis • ANOMALY pipeline identifies NuMTs in long-read data 🔬 #Bio #Genetics

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Daily #mtDNA intel: • Gstk1 inhibits cGAS/STING in septic hearts 🧬 • LL37-mediated mtDNA stress drives rosacea 🔬 • Nanosystems enable mtDNA control for wound repair

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Daily #mtDNA intel: • mtDNA inheritance enables lineage tracing 🧬 • LONP1 variants linked to diverse phenotypes • HSP90α/DRP1 axis triggers sepsis brain injury 🔬 #mitochondria

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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.

www.science.org/doi/10.1126/...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• RNA G-quadruplexes brake OXPHOS assembly 🧬
• EV-mediated mtDNA transfer drives osteoarthritis
• Photoactivatable POLRMT inhibition targets cancer 🔬
#CellBio

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Mitochondrial fusion safeguards stomatal defence in plants - Nature Plants Plants close their stomata to block pathogen entry, but how this defence is supported at the organelle level remains unclear. Our study reveals that immune signalling promotes MIRO1-dependent mitochon...

All together now 🗣️🗣️ : mitochondrial dynamics are vital *even in plants*! 🗣️🗣️ Fantastic work looking looking at the prime candidate for the mysterious & elusive plant mito fusion factors: MIRO1

The momentum for plant mito dynamics is picking up 💪🏻

www.nature.com/articles/s41...

Daily mtDNA Research Briefing Header

Daily #mtDNA intel:
• Nanosystems modulate mtDNA levels for healing
• LONP1 variants linked to diverse phenotypes
• MBD5/6 loss impairs respiration via chromatin 🧬
#genetics #biology

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To all #mitochondria lovers: Euromit 2026 early-bird registration is coming up!