Osman Lab

Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP pr...

🚨 Preprint alert! 🚨
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria

www.biorxiv.org/content/10.1...

Lost in translation? Chloroplasts can handle slang!
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social‬ @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1

Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance.

www.embopress.org/doi/full/10....

Fantastic!! Sooo coool!! 🤩🤩

Spectacular!! Congratulations!!

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

And here's the thread by @gavsturm.bsky.social explaining their herculean and fascinating work on #pearling #biophysics!

@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ?

@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"

need this here!

Yep, that's us! Thanks for posting!!!