Danielle Bitterman MD

Clinical Reporting: Mass General — unNatural Selection Signals Over Noise: Cleaning Up Cancer Trial Data

Mass General physician-scientist @daniellebitterman.bsky.social discusses how AI assists the clinical data pipeline leading to better treatments for patients. Listen to unNatural Selection & register for #WMIF2025 at the link in bio to hear more : www.unnaturalselection.net/podcast/s1e19
#MedTech

Our paper on multilingual reasoning is accepted to Findings of #EMNLP2025! 🎉 (OA: 3/3/3.5/4)

We show SOTA LMs struggle with reasoning in non-English languages; prompt-hack & post-training improve alignment but trade off accuracy.

📄 arxiv.org/abs/2505.22888
See you in Suzhou! #EMNLP

🚀 Join Us at the Forefront of AI & Cancer Care | Danielle Bitterman 🚀 Join Us at the Forefront of AI & Cancer Care Are you driven to use cutting-edge AI to transform patient outcomes in oncology? My lab within the AI in Medicine Program (Mass General Brigham, Har...

Are you driven to use AI to transform patient outcomes in oncology? My lab in the AI in Medicine Program (Mass General Brigham, Harvard Medical School) is seeking Postdoctoral Fellows to pioneer applications of AI—especially LLMs—in cancer care. More here: www.linkedin.com/posts/daniel...

Reliability of Large Language Model Knowledge Across Brand and Generic Cancer Drug Names | JCO Clinical Cancer Informatics PURPOSETo evaluate the performance and consistency of large language models (LLMs) across brand and generic oncology drug names in various clinical tasks, addressing concerns about potential fluctuati...

Reliability of Large Language Model Knowledge Across Brand and Generic Cancer Drug Names | JCO Clinical Cancer Informatics ascopubs.org/doi/abs/10.1... #JCOCCI @daniellebitterman.bsky.social

Does your LRM reason in your language? Check out new preprint led by ✨ @jiruiqi.bsky.social & @shan23chen.bsky.social. Implications for safety/human oversight & accuracy!

Led by @shan23chen.bsky.social!

Agents are all the rage and we need to track their abilities in the medical domain. Enter MedBrowseComp, the 1st benchmark to assess agents' abilities to reason, navigate the web, and search for verifiable med info!

Preprint: arxiv.org/abs/2505.14963
Site: moreirap12.github.io/mbc-browse-a...

"I think we have massive opportunity in cancer care to get patients to the right care, the most advanced care earlier, by taking those workforce shortages and using AI to get to solutions."

#STATBreakthrough

"The other thing I'm scared of, it's a patient's voice is going to be come lost in the conversation of on what type of AI is developed and how we implement it," Danielle

#STATBreakthrough

I’m thrilled to be in San Francisco for @statnews.com's Breakthrough West Summit! I’ll be bringing my firsthand perspective as a physician-scientist to speak about how AI is transforming cancer care, alongside leaders in the field.

Let's connect if you're here!
#STATBreakthroughSummitWest

A social card that reads Featured Session: AI in Cancer Care. Then underneath are four headshots and titles. They read: Danielle Bitterman, M.D., Clifford A. Hudis, M.D., Karen Knudsen, Ph.D., and STAT's Angus Chen.

AI in Cancer Care

Artificial intelligence has the potential to upend oncology, changing everything from diagnosis to treatment options. Get a wide-ranging view of how the use of technology could play out over the next few years.
Moderated by @angusrohan.bsky.social
#STATBreakthrough

ChemoTimelines 2025 Treatment regimens are key details in understanding the effects of genetic, epigenetic, and other factors on tumor behavior and responsiveness. As precision oncology progresses, insights into the fine...

Exciting news: we are organizing a shared task – 2nd edition of the Chemotherapy Treatment Timelines Extraction from the Clinical Narrative (text mining task) -- collocated with the Clinical NLP Workshop. Do LLMs solve the task? Check out bit.ly/ChemoTimelin...

graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

Conference and professional societies: PLEASE make hybrid options available for attendees and presenters at your conferences so that scientists from HHS-funded agencies can attend. These are unmissable opportunities to promote all the great intramural science and scientists from our government.

Unseen Commercial Forces Could Undermine Artificial Intelligence Decision Support Artificial intelligence (AI) is poised to transform health care, yet without robust safeguards, unseen commercial interests could distort care by prioritizing profit over patient well-being. The ph...

My Perspective in @NEJM_AI. AI could distort clinical decision-making in ways that prioritize profit over patient care. Oversight & regulation must go beyond performance metrics alone to address hidden commercial forces that could shape decision support. ai.nejm.org/doi/full/10....

My opinion as an actual NIH-funded researcher (unlike Vinay) at ucsf: his lies about how NIH dollars are used reflect a complete lack of understanding of how research is performed, a lack of respect for research, and are harmful to the entire biomedical research enterprise #grifter

Budgeting for the next year of my grants and they will all need to be rescoped, even before the 15% IDC rate. NCI funding at 83% for new awards and another 10% reduction for renewals (current state). Essentially, we are getting 50% of what we asked for...how is this sustainable? @carlbergstrom.com

As a cancer doctor I see every day how NIH-funded clinical trials save lives and has made the U.S. a leader in medical innovation. Here's one example: In the 1970s, childhood cancer survival was only 58%. Today it is 85%, largely thanks to NIH/NCI funding of Children's Oncology Group trials.

Congressional delegation outside USAID now: “We are here to shed a light on a crime unfolding before our eyes.”

Senator Andy Kim just went to the USAID building, talked to the security guard there to confirm employees are being barred entry, and then did a press gaggle right there in front to call it out.

This is doing something. This is making an effort on messaging. Other Democratic lawmakers: take notes.

Gay? Lesbian? Trans? Intersex?

NYC Health has health information for everybody. 🏳️‍🌈🏳️‍⚧️

LLM attachment styles: Secure - Claude, Anxious - DeepSeekR1/o1, Avoidant - Gemini

Am I wrong?

My lab is funded by the NIH to improve monitoring and management of cancer treatment side effects, so that patients can stay on treatments that are working against their cancer, and have a better quality of life during and after treatment

In addition to the research funded by the NIH, I am grateful and indebted to the dedicated NIH scientists & staff. Their work advances breakthroughs, scientific careers, and improves & saves lives across the U.S

this is the content I need today

this is amazing - congratulations Sasha!

Also applies broadly to treating trainees/junior faculty kindly and collaboratively.

Love this paper, thanks for this contribution @roxanadaneshjou.bsky.social and @rajpurkar.bsky.social. This is the way to start to understand how LLMs can and should perform for diagnostics - clinical vignettes don't reflect real world medical practice.

Supplementary Table 2.docx The TRIPOD-LLM Statement: A Targeted Guideline For Reporting Large Language Models Use Supplementary Table 2: Fillable TRIPOD-LLM checklist Section Item Checklist Item Research Design LLM Task Page Ti...

Oh I see it was converted. Here is an unofficial version: docs.google.com/document/d/1...

There is a word doc already provided in the supplementary materials.