Takeshi Irie

Any daily #alcohol consumption is associated with certain cancers, and the risk of #cancer increases with higher alcohol intake.

📊 This JAMA Insights discusses the evidence related to the
US Surgeon General’s Advisory on alcohol and cancer risk.

ja.ma/41EkKTy

Intra-arterial #lidocaine may improve survival in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolisation #TACE: is this too good to be true?

Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature Gene editors designed using artificial intelligence can undertake precision editing of the human genome.

Nature research paper: Design of highly functional genome editors by modelling CRISPR–Cas sequences

go.nature.com/3UAYBBB

Research Highlight: Computationally designed enzymes show potent catalytic activity www.nature.com/articles/s41...

Visual Abstract in #Anesthesiology - Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial) 🖌️ ow.ly/Kial50Wqw8a

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

—Why did you go to sleep?
—My mitochondria made me do it.
www.nature.com/articles/s41...

On the potential risk of gabapentin (Neurontin) for mild cognitive impairment and dementia
rapm.bmj.com/content/earl...

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

Peel-away nasal trumpet for fibreoptic tracheal intubation: buckle resistance and geometry of 3D-printed prototypes with high performance in airway manikin simulations Difficult airway management is a rare but high-stakes scenario encountered in perioperative and other acute care settings. The 2022 update to the American Society of Anesthesiologists difficult airway...

www.bjanaesthesia.org/article/S000...

We hope our efforts help pave the way to making difficult intubations easier. Thank yous to the team, and to @msk-anesthesia.bsky.social

Peel-away nasal trumpet for fibreoptic tracheal intubation: buckle resistance and geometry of 3D-printed prototypes with high performance in airway manikin simulations

3D-printed biomedical grade peel away nasal trumpets in nasal fiberoptic intubation of manikins. Concave longitudinal tear guides performed faithfully
sciencedirect.com/science/arti...
#PANTs #AFOI #airway #intubation #3D-printing

Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections

Not just shingles vaccine, but also RSV vaccine reduces the risk of dementia, which highlights the benefit of revving up the immune system in older individuals
www.nature.com/articles/s41...

The future of mobile healthcare!

#BlueSky #Medsky #BlueSky

It’s a SNaP: New Technique Paves Way for Scalable Therapeutic Nanoparticle Manufacturing Bridging the gap between lab-scale drug delivery research and large-scale pharmaceutical manufacturing

An NYU Tandon research team led by Assistant Prof Nathalie Pinkerton has developed Sequential NanoPrecipitation (SNaP), a breakthrough in drug delivery manufacturing.

#NYUTandonMade @ieeespectrum.bsky.social

This is figure 6, which shows the pathways of nanoplastics-induced gut microbiota changes.

Nanoplastics can compromise intestinal integrity in mice by altering the interactions between the gut #microbiome and the host, according to a paper in Nature Communications. go.nature.com/4jLgF6u #medsky 🧪

Programmable RNA acetylation with CRISPR–Cas13 - Nature Chemical Biology Yu et al. developed a programmable RNA acetylation system using dCas13–eNAT10 to specifically install N4-acetylcytidine on target RNAs in cells and in vivo, enabling functional studies of RNA acetylat...

A programmable RNA acetylation system using dCas13-eNAT10 is developed to install N4-acetylcytidine on target RNAs in cells and in vivo, enabling functional studies of RNA acetylation and revealing the unique role of RNA acetylation in transcript localization

www.nature.com/articles/s41...

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...

Grant Cancellation Web Form WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP? The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower

Are you a PI of a federal grant cancelled by the Trump administration?

Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪

forms.office.com/pages/respon...

Sleep apnea pill shows striking success in large clinical trial Drug combination targeting lax airways is nearing an FDA submission

Many with sleep apnea aren’t adequately treated because they find continuous positive airway pressure machines too burdensome. A new pill may offer an alternative.

The initiation of vasopressin following recommendations by a reinforcement learning model was associated with decreased mortality in patients with septic shock already receiving norepinephrine.

ja.ma/4jaZE5d

A team co-led by Ludwig @unil.bsky.social’s Helen Carrasco Hope & Nicola Vannini reports that age-related metabolic decline impairs CAR-T cell function. Replenishing NAD+, a key metabolic molecule, in the cells restores their efficacy in preclinical models of cancer. bit.ly/4kspK4H

#CanSky #OncoSky

Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...

They're terminating OPT.

Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.

6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com

World first: ultra-powerful CRISPR treatment trialled in a person Immune-cell function improved in a teenager whose DNA was altered using prime editing.

The CRISPR family’s most versatile member has made its medical debut: a cutting-edge gene-editing technique known as prime editing has been used to treat a person for the first time

https://go.nature.com/3YNta9V

Personalized Gene Editing to Treat an Inborn Error of Metabolism. #NEJM #TIC2025

www.nejm.org/doi/full/10....

All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊

Estrogen and Progesterone Stimulate the Body to Make Opioids A new study found that female hormones can suppress pain signals before they reach the brain by making immune cells near the spinal cord produce opioids.

New study from @ucsfmedicine.bsky.social shows estrogen and progesterone signal T-regs in the meninges to produce opioids, stopping pain before it reaches the brain. tiny.ucsf.edu/pG5MU9

#Remimazolam is increasingly used as an induction agent for general anaesthesia. The optimal bolus induction dose for children is estimated to be 0.45-0.60mg/kg for age 1-6 years and 0.35-0.45mg/kg in 6-12 years

Exclusive: NSF faces radical shake-up as officials abolish its 37 divisions Changes seen as a response to presidential directives on what research to fund

Exclusive: National Science Foundation staff were told today that the agency’s 37 divisions—across all eight directorates—are being abolished and the number of programs within those divisions will be drastically reduced.

"Approximately 5%of annual cancer diagnoses or
100,000 cancers were projected to result from [U.S.] CT utilization in 2023.
"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832778

RSI — Project for Universal Management of Airways

But I'm sure you'd agree that's clearly outdated & something the majority of clinicians would disagree with.

In the @universalairway.org guidelines we've defined RSI based on a spectrum of practice that adheres to specific principles.

www.universalairway.org/rsi