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Rémi Fronzes

@fronzeslab.bsky.social

🔬 CNRS Research Director, Bordeaux | Structural biologist & microbiologist 🏃‍♂️ Runner & 🚴 Cyclist (Velotaf) ⛰️ Mountain & nature lover 🎓 UCL/Birkbeck & Institut Pasteur alumnus fronzeslab.cnrs.fr #cryoEM #cryoET #microsky

3,190 Followers  |  3,690 Following  |  862 Posts  |  Joined: 21.12.2023
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Posts by Rémi Fronzes (@fronzeslab.bsky.social)

Je rêve ou il y a des pénuries d’essence dans les stations !

Il faut arrêter d’écouter les chaînes infos les gens !!!

02.03.2026 18:41 — 👍 0    🔁 0    💬 0    📌 0

Wow. Really really useful paper and also really awesome thread / summary.

27.02.2026 04:13 — 👍 21    🔁 5    💬 1    📌 0

Nor donated money to Donald Trump’s 2025 inauguration committee

27.02.2026 21:14 — 👍 0    🔁 0    💬 0    📌 0

Dario Amodei did not attend Donald Trump’s inauguration.

Just saying

27.02.2026 21:10 — 👍 1    🔁 0    💬 1    📌 0
27.02.2026 21:02 — 👍 0    🔁 0    💬 0    📌 0
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Type IV secretion systems: reconciling diversity through a unified nomenclature This review presents a comprehensive overview of Type IV Secretion Systems (T4SSs), focusing on their structural, functional, and evolutionary diversity ac

Happy to share a new review proposing a unified nomenclature for T4SSs.
Great collaboration with Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson and our team.
academic.oup.com/femsre/artic...
#T4SS#Microbiology

18.02.2026 14:13 — 👍 21    🔁 15    💬 0    📌 2
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À l’ombre de la vieille dame : épisode 10/10 du podcast L'épopée de Lady Liberty AUDIO • L'épopée de Lady Liberty, épisode 10/10 : À l’ombre de la vieille dame . Une série inédite proposée par France Inter. Écoutez Face à l'histoire, et découvrez nos podcasts en ligne.

Série à écouter !

20.02.2026 19:08 — 👍 0    🔁 0    💬 0    📌 0
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The political effects of X’s feed algorithm Nature - Among users initially on a chronological feed, 7 weeks of exposure to X’s algorithmic feed in 2023 shifted political attitudes and account-following behaviour in a more conservative...

Well, science confirms that X is a global propaganda machine ?

19.02.2026 19:54 — 👍 2    🔁 0    💬 0    📌 0
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‘Nice shoes, mate’: we road test the brick-shaped £199 Lego Crocs Lego and Crocs have joined forces to create oversized Lego-shaped shoes. Are they as ridiculous as they sound? We sent our most podophilic writer to find out

1 April has come early this year.

15.02.2026 12:22 — 👍 8    🔁 1    💬 1    📌 0
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Les crues et inondations en Lot-et-Garonne en images Rupture de digue et hébergement d’urgence à Aiguillon, routes et plaines englouties dans le Val de Garonne… Les images de ce samedi 14 février

C’est chez moi ! Bon courage à tous les Aiguillonais !

14.02.2026 17:37 — 👍 1    🔁 0    💬 0    📌 0
One on left is a black dog and above it the words “Reality”. Below it is “I chased a squirrel” 

One the right is a black dog and above it says “LinkedIn”. Below it says, 

Proud to announce that I effectively executed a rapid-response squirrel displacement strategy to mitigate potential yard intrusions.

Humbled by the unwavering support of my family and local stakeholders.

This experience reinforced the importance of vigilance, ownership, and continuous improvement.

Looking forward to scaling this impact in future engagements.

One on left is a black dog and above it the words “Reality”. Below it is “I chased a squirrel” One the right is a black dog and above it says “LinkedIn”. Below it says, Proud to announce that I effectively executed a rapid-response squirrel displacement strategy to mitigate potential yard intrusions. Humbled by the unwavering support of my family and local stakeholders. This experience reinforced the importance of vigilance, ownership, and continuous improvement. Looking forward to scaling this impact in future engagements.

😂

11.02.2026 12:10 — 👍 4382    🔁 1169    💬 68    📌 98

La couleur bleue aurait été naturelle

07.02.2026 07:40 — 👍 3    🔁 0    💬 0    📌 0
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AI is not a peer, so it can’t do peer review If we still believe that science is a vocation grounded in argument, curiosity and care, we can’t delegate judgement to machines, says Akhil Bhardwaj

AI is not a peer, so it can’t do peer review.

To the point !

04.02.2026 07:46 — 👍 5    🔁 1    💬 0    📌 0
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IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

02.02.2026 07:25 — 👍 3    🔁 2    💬 0    📌 1
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Save the date 🤩🤩🤩!

Our student-led Young Scientist Symposium will take place on the 4th & 5th of June this summer!

More information and registration available soon!

29.01.2026 12:03 — 👍 7    🔁 8    💬 0    📌 0

And @wikipedia.org is here on Bsky!

Give them a follow, and throw them a little cash to help their mission of being a resource of facts in a world where information is both becoming more critical and being more poisoned.

28.01.2026 14:03 — 👍 36    🔁 12    💬 2    📌 2
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France Universités condamne les attaques formulées sur CNews France Universités condamne les attaques formulées sur CNews contre plusieurs universités le 27 janvier 2026.

🛑 Parce que l’Université est un pilier de la démocratie, elle doit être défendue contre celles et ceux qui entendent plonger notre pays dans la nuit.
franceuniversites.fr/actualite/fr...

28.01.2026 15:04 — 👍 89    🔁 50    💬 1    📌 4
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Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections Macrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation …

Lactic acid lover? Check out @ronni.bsky.social 's new work in
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...

27.01.2026 19:11 — 👍 26    🔁 16    💬 1    📌 2
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The party behind Kyle Rittenhouse and J6 think Alex Pretti's legal gun was the problem? Seriously?!?

27.01.2026 16:46 — 👍 2391    🔁 574    💬 66    📌 41

Dear colleagues in science - it is time to stop normalising the emerging fascism of the US by attending conferences there as though everything is fine.

25.01.2026 10:15 — 👍 44    🔁 15    💬 8    📌 3
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When cryo-EM modeling meets structure prediction Nature Structural & Molecular Biology, Published online: 23 January 2026; doi:10.1038/s41594-026-01744-4Accurately interpreting density maps into atomic models is a central yet challenging goal of cryo-EM. Two studies now reveal distinct ways in which protein structure prediction can be incorporated into cryo-EM model building to enable more accurate and robust automated construction of protein atomic models from density maps.

New online: When cryo-EM modeling meets structure prediction

23.01.2026 20:26 — 👍 10    🔁 6    💬 0    📌 0

looks very good to me !

19.01.2026 07:45 — 👍 1    🔁 0    💬 0    📌 0

For the French speaking people here.

18.01.2026 11:15 — 👍 2    🔁 1    💬 0    📌 0

I love that !

18.01.2026 11:06 — 👍 4    🔁 2    💬 0    📌 0
Two D-loop resolution systems enable natural genetic transformation in bacteria Natural transformation is a widespread mechanism driving genetic exchanges in bacteria. It proceeds by the capture and internalization of exogenous DNA in linear single strands, ultimately integrated in the genome by homologous recombination. It is unknown how the RecA-directed D-loop intermediate of this dedicated recombination pathway is processed. We report that resolution of the transformation D-loop depends on two endonucleases of opposing phylogenetic distribution in bacteria. One is YraN, which has co-evolved and interacts with the ComM helicase, known to extend DNA recombination at the transformation D-loop. The other is CoiA, which is restricted to the Bacillota. CoiA is shown to be a resolvase of the transformation D-loop, extended by the RadA helicase in these species. We demonstrate that both YraN and CoiA act synergistically with their cognate helicases. These findings reveal that bacteria have evolved two helicase/nuclease pairs for the maturation and recombination extension of the transformation D-loop. ### Competing Interest Statement The authors have declared no competing interest. Agence Nationale de la Recherche, https://ror.org/00rbzpz17, ANR-20-CE12-0004, ANR-10-BLAN-1331, ANR-17-CE13-0031, ANR-22-CE44-0044, ANR-10-LABX-62-IBEID, PIA/ANR-16-CONV-0005 Fondation pour la Recherche Médicale, https://ror.org/04w6kn183, FDT202001010890 European Union's Horizon research and innovation programme. Marie Skłodowska-Curie Postdoctoral Fellowships, 101208987 National Institute of Health, USA, R35GM128674

#microsky
Massive update of preprint with @polardlab.bsky.social!
Bacteria have evolved two systems to recombine extracellular DNA
www.biorxiv.org/content/10.1...
Kudos to lead authors Léo Hardy, Violette Morales and Clothilde Rousseau, and to outstanding Dalia's lab and @epcrocha.bsky.social
🧵⬇️

16.01.2026 16:23 — 👍 18    🔁 8    💬 1    📌 0
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L’Agence nationale de la recherche (#ANR) est contrainte d’adapter temporairement ses activités dans le cadre des services votés. Le calendrier et la mise en œuvre des appels à projets, dans l’attente de l’adoption de la loi de finances pour 2026, sont précisés dans ce #communiqué ➡ bit.ly/3NyLwbI

08.01.2026 15:48 — 👍 11    🔁 18    💬 0    📌 3
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I am thrilled to share with you the outcome of the first collaboration with Albesa-Jove's lab (albesalab.org), in which we characterised the molecular mechanisms underlying the binding of a T6SS adaptor-effector pair in P. putida, Tap3–Tke5. (🧵1/9). Read the full paper here: doi.org/10.1038/s443...

14.01.2026 11:38 — 👍 26    🔁 13    💬 1    📌 0
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a man with a mustache is standing in a room with the words ground control to major tom written below him ALT: a man with a mustache is standing in a room with the words ground control to major tom written below him
09.01.2026 21:22 — 👍 1    🔁 0    💬 0    📌 0

Bonjour, afin de contribuer à la présence des institutions sur Bluesky (et leur permettre de faciliter leur exil de X) , j'ai créé ce starterpack des comptes institutionnels nationaux français présents.

08.01.2026 10:10 — 👍 755    🔁 399    💬 66    📌 19
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Bluesky Recipes for Difficult Days: A Survival Guide for Finding Joy in Life and Food Bluesky Recipes for Difficult Days: A Survival Guide for Finding Joy in Life and Food eBook : Smith, David K: Amazon.co.uk: Books

To make your new year better, I'm essentially giving away my eBook (99p). Simple recipes to nourish the soul and wellbeing tips - it won the Gourmand World Cookbook Award for Food & Mental Health.
If you enjoy, please leave a review.
www.amazon.co.uk/dp/B0DWLYCR96
#FoodSky #BookSky #Foodie #Cookbook

08.01.2026 10:38 — 👍 6    🔁 1    💬 0    📌 0