Vousden Lab

Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities - PubMed Cancer cells undergo changes in metabolism that distinguish them from non-malignant tissue. These may provide a growth advantage by promoting oncogenic signaling and redirecting intermediates to anabolic pathways that provide building blocks for new cellular components. Cancer metabolism is far from …

Our group leader, Prof. Vousden, has co-authored a new textbook on cancer metabolism with Prof. Navdeep Chandel and Prof. Ralph DeBerardinis. Check it out!
pubmed.ncbi.nlm.nih.gov/39500632/

Interested in tumour metabolism? 🧪
The Keystone Symposia "Tumour Metabolism: New Frontiers in Diet, Microbiome, and Beyond” is taking place next June. Exciting science and discussions ahead — join us there!
#KeystoneSymposia
#TumourMetabolism
#DietandCancer

We're incredibly proud to share that our PI has been awarded the Clowes Award - the oldest award by @theaacr.bsky.social - in recognition of her contributions to cancer research!
She will give her award lecture on April 28, at 5:30 p.m. CT in Chicago.
See you there!😎
@crick.ac.uk
#ProudVousdenites🎉

Ludwig Cancer Research was well represented in a recent @cancergrand.bsky.social panel on The Future of Cancer Research, which included CEO and Scientific Director Chi Van Dang, Scientific Advisor @labvousden.bsky.social and Ludwig @mitofficial.bsky.social Co-director Tyler Jacks.

#CanSky #OncoSky

Congrats!😍

Kicking off spring with exciting news! Our postdoc, @marthamz.bsky.social has been awarded the highly competitive EACR-Mark Foundation Postdoctoral Fellowships. Congratulations!👏💐🎉

@helloeacr.bsky.social @crick.ac.uk
#Pancreaticcancer
#womeninSTEM

🥳🥳🥳

Merry Crickmas!! 🎄🎅🪩

Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...

Very happy to share the latest preprint from the lab. We find that during cell competition, winners induce an increase in proline metabolism in loser cells, and this drives their elimination through repression of the integrated stress response.
biorxiv.org/cgi/content/...

Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment | PNAS The consequences of reactive oxygen species (ROS) in cancer cells are complex and have been shown to both promote and retard tumorigenesis in diffe...

Recent publications from our lab:

1. Invited review on obesity and cancer by Estel Solsona-Vilarrasa
febs.onlinelibrary.wiley.com/doi/10.1111/...

2. Update on ROS regulation by TIGAR in PDAC and its communication with the tumour stroma, by Eric Cheung
www.pnas.org/doi/abs/10.1...

Enjoy the read!

Lab Retreat 2024 @royalsociety.org 😍