Michael Drazer

Losing my mind. Let's go!

I've always been a fan of what the Allen Institute is doing. New in Nature: OpenScholar, an 8B RAG model for scientific literature, outperforms GPT-4o by 6% on correctness. Experts preferred its answers over human-written ones 51%-70 of the time. www.nature.com/articles/s41... 1/3 🧵

Deep contrastive learning enables genome-wide virtual screening Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...

In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

I’ve always preferred reference hiring over interviews.

Come check out our poster for an ongoing trial of ASTX727 +/- Iadademstat in accelerated/blast-phase MPNs #ASH25

"All my homies in the county in Cell Block 6 /
The grits when there ain't enough eggs to cook /
And for D.B. Cooper and the money he took /
You can look for answers, but that ain't fun /
Now get in the pit and try to love someone!"

- Robert James Ritchie

Leadership simplified:

Hire good people.
Give them the tools to succeed.
Provide them the security to take calculated risks.
Get out of their way.
Let go of over-controlling.
Support, don't thwart.
Cultivate intrinsic motivation.
Trust them to do their job.

Team culture does not form during meetings or scheduled activity.

It forms during the in between moments. The cool down conversations, the shared anxiety while awaiting a race, the adventures once the performance is complete and you have got hours to kill in a different city.

Best Big City: Chicago Wins Award 9th Year in a Row Learn why Chicago was voted the Best Big City for the 9th consecutive year by exploring our vibrant culture, welcoming inclusion, and so much more.

BEST BIG CITY IN THE US 9 YEARS IN A ROW.

While critics try to paint Chicago as something to fear, the rest of the world knows the truth — this is the best big city in America.

Simple scaling laws control the genetic architectures of human complex traits Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...

Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.

Thread:
journals.plos.org/plosbiology/...

90% now, 5% later

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

Amplifying one of our neighboring programs - great place to train and GR is a great place to live

(S. E. M. Hill et al. J. Clin. Psychol. Med. Settings 29, 557–569; 2022)

"Other studies, notably a 2022 review on the quality of academic mentoring, describe how supervisors who engage closely with their students can benefit by learning new techniques and discovering emerging fields, and say that they often feel intellectually recharged."

What makes PhD students happy? Good supervision Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

"A 2019 report from the US NASEM report on mentorship in science notes that researchers who invest time in their students tend to lead more-productive, more-collaborative groups and attract stronger future students than those who do not."

www.nature.com/articles/d41...

Awesome application of genomics + cancer bio

Good news for @alice.soragnilab.com, SFPM, and rare disease models. Bad news for mouse cancer enthusiasts (humans are unreliable models of mouse disease).

How would you prove causality, considering ~20% of patients over 70 have CHIP?

Christiana Fogg, 11.7 miles into the 2024 Stone Mill 50-miler. Photo: Dan Reichmann, MCRRC

In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪

A study of gene expression in the living human brain - Molecular Psychiatry Molecular Psychiatry - A study of gene expression in the living human brain

Different results than those found in preserved samples www.nature.com/articles/s41...

Tracing the evolution of sequencing into the era of genomic medicine Nature Reviews Genetics, Published online: 15 August 2025; doi:10.1038/s41576-025-00884-5Extraordinary advances in genomic science have defined the twenty-first century, transforming our understanding of human biology in both health and disease. This timeline Perspective charts two decades of genomic innovation since the human genome reference sequence became available, highlighting the evolution of sequencing technologies and how they, combined with computational advances, paved the way for genomic medicine.

New online! Tracing the evolution of sequencing into the era of genomic medicine

In the ENHANCE-2 study, Magro/Aza did not improve OS of patients with TP53-mutated AML. buff.ly/8DeMMxH #hemesky

Comprehensive genome analysis and variant detection at scale using DRAGEN - Nature Biotechnology DRAGEN rapidly identifies diverse types of genetic variants.

DRAGEN rapidly identifies diverse types of genetic variants go.nature.com/4eXQRT1
rdcu.be/ezphs

Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer - PubMed Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer

In a recently published article in NEJM, Ari Rosenberg, MD, and Everett Vokes, MD, discuss the promise and complexities of the KEYNOTE-689 trial, which shows event-free survival benefits from pembrolizumab in curative-intent settings. @arirosenbergmd.bsky.social
pubmed.ncbi.nlm.nih.gov/40532147/

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science

https://go.nature.com/4kIRR01

+1

Guidelines for writing:

• Just get started—no writer's block; only getting started block
• Write for clarity first
• Write for elegance second
• Delete excess words
• Don't write and edit at same time
• OK for first drafts to stink
• Read your work aloud
• Get good sleep

In a study on world class performers, those who made it world class:

-Had more multisport than specialized practice
-Started their main sport later
-Accumulated less practice
-Initially progressed slower than national class peers