Michael Drazer

Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer - PubMed Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer

In a recently published article in NEJM, Ari Rosenberg, MD, and Everett Vokes, MD, discuss the promise and complexities of the KEYNOTE-689 trial, which shows event-free survival benefits from pembrolizumab in curative-intent settings. @arirosenbergmd.bsky.social
pubmed.ncbi.nlm.nih.gov/40532147/

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science

https://go.nature.com/4kIRR01

+1

Guidelines for writing:

• Just get started—no writer's block; only getting started block
• Write for clarity first
• Write for elegance second
• Delete excess words
• Don't write and edit at same time
• OK for first drafts to stink
• Read your work aloud
• Get good sleep

In a study on world class performers, those who made it world class:

-Had more multisport than specialized practice
-Started their main sport later
-Accumulated less practice
-Initially progressed slower than national class peers

🚨 New research finds women with BRCA1/2 mutations who received textured breast implants after mastectomy face a 16x higher risk of developing BIA-ALCL, a rare lymphoma. Study highlights need for awareness years after surgery.

🔗 https://bit.ly/404WEk1

@bloodjournals.hematology.org

How awesome is this?!

JAMA Network Open @jamanetworkopen.com - an open access journal in the JAMA Network - is now on BlueSky!

#MedSky

CrossFilt: A Cross-species Filtering Tool that Eliminates Alignment Bias in Comparative Genomics Studies www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/kennethabarr...

Elon/DJT break up is the biggest split since WHO/ICC

Classic.

@greenwell.bsky.social, your media training is working because I just saved your audiobook to my Spotify library. Keep fighting the good fight, this is an important issue.

Out today in @pnas.org! www.pnas.org/doi/10.1073/...

Science’s ‘Gollum effect’: PhDs bear brunt of territorial behaviour Nature - Survey respondents at all career stages report colleagues engaging in territorial and possessive behaviours — but early-career researchers are most often affected.

💍 The Gollum Effect: possessive behaviours, attempts to undermine others, and efforts to restrict access to data, resources or opportunities

https://go.nature.com/4mxAJvG

Key rules to achieve sustainable success:

1. Consistency trumps perfection.
2. Be a minimalist to be a maximalist.
3. Have a quiet ego.
4. Focus on the process, not results.
5. Establish a secure but flexible identity.
6. Stress + Rest = Growth

Hahahaha I knew you would appreciate that. Great meme as always

The 2016 paper is correct - the "what do with a D14 marrow" question is ripe for a randomized study, but - as was the case in 2016 - there is unfortunately little incentive to address this in the current US system.

Prediction of CR following a second course of ‘7+3' in patients with newly diagnosed acute myeloid leukemia not in CR after a first course

Finally, there is the 2016 effort led by Dr. Estey that beautifully summarizes this question. It's cited in the NCCN AML guidelines, but isn't covered in the NCCN discussion section to the extent it should be.

pmc.ncbi.nlm.nih.gov/articles/PMC...

Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia - PubMed A day 14 BM biopsy may have suboptimal sensitivity for the detection of residual leukemia. Some patients with an IR on day 14 may not require re-induction chemotherapy, but instead, may benefit from c...

In addition to this study from the Duke team, which similarly questioned the utility of re-inducing these patients (and the associated morbidity and mortality) versus awaiting count recovery.

pubmed.ncbi.nlm.nih.gov/23046833/

Kinetics of bone marrow blasts during induction and achievement of complete remission in acute myeloid leukemia - PubMed Kinetics of bone marrow blasts during induction and achievement of complete remission in acute myeloid leukemia

And this paper, which identified a subset of patients whose day 14 marrows were ominous (but improved by day 21 and who ultimately entered remission at count recovery):

pubmed.ncbi.nlm.nih.gov/18519513/

Bone marrow evaluation for diagnosis and monitoring of acute myeloid leukemia The diagnosis of acute myeloid leukemia (AML) can be made based on peripheral blood or bone marrow blasts. In this review, we will discuss the role of bone marrow evaluation and peripheral blood monit...

Some really great stuff - even years later - including this fantastic 2018 paper reviewing the evidence for/against the day 14 marrow:

pmc.ncbi.nlm.nih.gov/articles/PMC...

Was discussing a recent case with a colleague when the utility of the day 14 marrow in our patients undergoing intensive induction for AML was discussed. Prompted a return to the "old" literature on this topic, much of which was written by Eli Estey (and @drchrishourigan.bsky.social).

Vicar of Christ

YouTube video by GOLDLABCOLORADO GoldLab Symposium 2015 - Michael Joyner, M.D.

Classic lecture from Michael Joyner: "Is reductionism killing biomedical research?"

youtu.be/dG8lszogw_E?...

Nearly a decade on, it has aged well

We've worked on eQTLs and CRISPR for 10+ years now, and 4 years ago I hypothesized about their orthogonal strengths and weaknesses, for a review paper with @dgmacarthur.bsky.social. It’s exciting to finally have enough empirical data for a systematic analysis.
www.science.org/doi/10.1126/...

1/ 🧬 A Hitchhiker’s Guide to Long-Read Genomic Analysis is out now!

This mini-review walks through the latest advances in long-read DNA sequencing — from assemblies to variant calling to epigenetics.

Link 🔗 genome.cshlp.org/content/35/4...
🧵👇

Probably a canary in a coal mine

a man with long blonde hair and a beard is holding a fishing rod ALT: a man with long blonde hair and a beard is holding a fishing rod

Bulleit

Fact check:

True.

Image showing a PICO summary for: Factors associated with survival following allogeneic transplantation for myeloid neoplasms harboring TP53 mutations by Baranwal et al. featured in the Stem Cell Evidence Alert - April 2025

From the #StemCellEvidence Alert:

Factors associated with survival following allogeneic transplantation for myeloid neoplasms harboring TP53 mutations
by Baranwal et al.
www.stemcellevidence.com/alerts/artic...
#MedSky

The technology revolution solving medical mysteries for families - Research Pulse: Future focussed health insights CALHN Research Pulse podcast | Season 3 Episode 2 |Recent decades have seen an explosion in the techniques scientists use to study genes.In this episode of Research Pulse, we learn how knowledge about...

Happy to have had a chat about some of our recent work in inherited hematological diseases and pregnancy loss published as a CAHLN Research Pulse podcast. Team effort. @SAPathology @CCB_Research @UniversitySA @SAHealth www.buzzsprout.com/1982738/epis...