PRIMED Consortium

Funding for BGE sequencing and analyses are provided through the NIH-funded PRIMED Consortium @prsmethods.bsky.social

For more information and how to apply for access, visit primedconsortium.org/research/our...

/end

The release includes self-reported basic demographics, anthropometric traits, cardiometabolic outcomes, and Blended Genome-Exome sequencing data on 621 study participants

2/

🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org!
anvilproject.org/news/2025/11...
1/

Recommendations for responsible use of population descriptors in polygenic risk score development - Nature Genetics In this Perspective, authors from the Polygenic Risk Methods Development (PRIMED) Consortium highlight the ethical and analytical impact of population descriptors in polygenic risk score development a...

📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun

www.nature.com/articles/s41...
in @natgenet.nature.com

🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social !

"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."

Quantifying Social Determinants of Health for Disease Prediction: A Multi-Level Approach Using Healthy People 2030 and All of Us Data Despite the growing recognition that social determinants of health (SDoH) play a prominent role in shaping health outcomes, inconsistent measures across health systems and research studies - and the a...

👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...

ASHG 2025 PRIMED Abstracts

Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...

👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

‪The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!

👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries

www.medrxiv.org/content/10.1...

📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference

In-person registration closes Aug 19: https:/bit.ly/anvil2025

Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!

www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...

🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!

- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual

Don’t miss it!

Co-authors include @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the Data Sharing Working Group!

@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium

🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏

See also our thread on the pre-print - bsky.app/profile/prsd...

ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social

www.cell.com/ajhg/abstrac...

Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social!

Genetic information can help improve risk prediction for a broad range of health outcomes.

Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...

I wrote a thing.

I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.

Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

Find this and other @prsdiversity.bsky.social publications and preprints on our website, primedconsortium.org/publications...

They also discuss current challenges in fully using local ancestry in genetic epidemiological studies and suggest future directions towards its full usage. 3/

Quan Sun and colleagues at the EPIC-PRS PRIMED Site review methods to infer and incorporate local ancestry in various analyses including admixture mapping, association testing, and polygenic prediction. 2/

Opportunities and challenges of local ancestry in genetic association analyses Recently, admixed populations make up an increasing percentage of the US and global populations, and the admixture is not uniform over space or time o…

👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/
www.sciencedirect.com/science/arti...

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

📣 Call for community feedback!

The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...

Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

H/t to co-authors @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the entire Data Sharing Working Group! @prsdiversity.bsky.social is an NHGRI and NCI funded Consortium 7/

Additionally, we make recommendations for policy and practice across all these areas, to inform future research and data sharing efforts 6/

We introduce key policy clarifications and suggested approaches to sharing genomic summary results, such as new polygenic risk score models - a key product of @prsdiversity.bsky.social 5/