PRIMED Consortium

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

‪The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!

👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries

www.medrxiv.org/content/10.1...

📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference

In-person registration closes Aug 19: https:/bit.ly/anvil2025

Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!

www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...

🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!

- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual

Don’t miss it!

Co-authors include @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the Data Sharing Working Group!

@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium

🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏

See also our thread on the pre-print - bsky.app/profile/prsd...

ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social

www.cell.com/ajhg/abstrac...

Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social!

Genetic information can help improve risk prediction for a broad range of health outcomes.

Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...

I wrote a thing.

I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.

Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

Find this and other @prsdiversity.bsky.social publications and preprints on our website, primedconsortium.org/publications...

They also discuss current challenges in fully using local ancestry in genetic epidemiological studies and suggest future directions towards its full usage. 3/

Quan Sun and colleagues at the EPIC-PRS PRIMED Site review methods to infer and incorporate local ancestry in various analyses including admixture mapping, association testing, and polygenic prediction. 2/

Opportunities and challenges of local ancestry in genetic association analyses Recently, admixed populations make up an increasing percentage of the US and global populations, and the admixture is not uniform over space or time o…

👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/
www.sciencedirect.com/science/arti...

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

📣 Call for community feedback!

The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...

Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

H/t to co-authors @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the entire Data Sharing Working Group! @prsdiversity.bsky.social is an NHGRI and NCI funded Consortium 7/

Additionally, we make recommendations for policy and practice across all these areas, to inform future research and data sharing efforts 6/

We introduce key policy clarifications and suggested approaches to sharing genomic summary results, such as new polygenic risk score models - a key product of @prsdiversity.bsky.social 5/

We describe challenges and solutions to sharing the output of harmonizing genotypes and phenotypes given that we are secondary users of pre-existing data sources 4/

Technical implementation of data sharing in the @anvilproject.org cloud platform includes managing access to data storage and analysis workspaces, and developing new tools and workflows 3/

We describe design and implementation of data sharing policies and procedures to bring diverse data together, including coordinated dbGaP applications and a Consortium Data Sharing Agreement 2/

Data Sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking Sharing diverse genomic and other biomedical datasets is critical to advance scientific discoveries and their equitable translation to improve human health. However, data sharing remains challenging i...

👀🔖 Curious how a research consortium manages sharing data to collaborate on improving genetic risk prediction in global populations? Check out this new preprint from the @prsdiversity.bsky.social data sharing working group! arxiv.org/abs/2502.09351 1/

Researchers look to genetics to better understand heart disease in South Asians People of South Asian descent are more likely to be affected by heart disease, but their risks often go unnoticed. Researchers are looking to genetics to learn more and prevent early deaths.

So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social

📹🍿🧬 Check out @yunfeng-ruan.bsky.social's recent talk at the @broadinstitute.org, "Polygenic risk scores: method development and application" in our growing collection of videos on the @prsdiversity.bsky.social website primedconsortium.org/education#vi...

📣 👀 🧬 Join @prsdiversity.bsky.social and @geneticssociety.bsky.social tomorrow for a journal club on developing polygenic risk scores in diverse populations

NHGRI appoints Erin Ramos as Director of the Division of Genome Sciences In the January 2025 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Erin Ramos as the new director of the Division of Genome Sciences (DGSci).

We're delighted to have the @prsdiversity.bsky.social Perspective featured in the Genomics Landscape, the NHGRI Director's monthly newsletter, https://buff.ly/3PsUJjF. The Perspective outlines goals, approaches, and ongoing activities, including new PRS methods and models.