Longwei Bai

Congratulations🥳🥳

Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...

Thank you, bro🙈🙈

Huge thanks to the whole Leulier's team for their support over the past four years😘😘

Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative slee...

elifesciences.org/articles/99999

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

Very happy and proud to share the latest work from our lab.
Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

Very happy to share our latest lab publication!
The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators!
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...

An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...

Lastest work from Zhai's lab. mTORC1-mediated nutrient sensing orchestrates metabolic processes to maintain physiological homeostasis and influences organismal ageing in Drosophila.
www.biorxiv.org/content/10.1...

Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

Happy to share our new preprint! We explored the mechanisms underlying differences between male and female #Drosophila in susceptibility to intestinal #infection. #symbiosky
#immunity #AcademicSky #insect #symbiosis

Discovery of a gut hormone that regulates protein intake, sleep, and influences lifespan
www.nature.com/articles/s42... (open-access) @natmetabolism.nature.com
www.nature.com/articles/s42... in mice and flies

Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...

Happy to share our latest minireview on
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity journals.asm.org/doi/10.1128/...
#immunity #infection #antimicrobialpeptides #microbiome #Drosophila #AcademicSky #insect #endosymbiont #symbiosis

Glutamine-glutamate intercellular relay model for brain sparing

Our latest preprint…Adrien Franchet, Yuhong Jin et al @crick.ac.uk show that circulating glutamine drives brain sparing during nutrient restriction. Great collab with labs of Yaël Grosjean and Ian Gilmore.
#metabolism #Drosophila #neuralstemcells

www.biorxiv.org/content/10.1...

The lab will be represented at #Dros25.
@longweibai.bsky.social presenting in the Physiology session on Friday at 5pm after I give the intro to his talk in a plenary Thursday morning 😉.
#Drosophila #microbiome friends, let’s catch up and go see Longwei ´s talk he has a really cool story to share.

And enjoyed it even more when highlighting it in Cell Host Microbe
Free access link here:
authors.elsevier.com/a/1kbY9_hwRX...

Drosophila larval gut transcriptome reveals a microbe-mediated intestinal tissue growth via Ecdysone during adaptive growth Juvenile growth is an adaptive trait since chronic undernutrition leads to reduced growth rate and delayed maturation. Using Drosophila and mouse gnotobiotic models, we previously established the evol...

Latest preprint from the Lab, co-led by Cathy Ramos, lecturer in the team and pushed to the final line by Longwei Bai, Ph’d candidate.

Deals with microbiome (what else… 😉), guts and steroid hormone in flies.

#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...