Longwei Bai

ShineGAL4 FLP-out clones

#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social

@dev-journal.bsky.social
tinyurl.com/4jpw9jd6

Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...

Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3

Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...

📣First preprint of the lab📣 Did that really happen?😅

Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...

Happy 2026 everyone- the time has come to apply!
Registration for this exciting Dev Bio conference is until the end of January!

Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social

Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.

Thank you so much, Dafni😀😀

Thank you, Julie 😀😀

A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signalling Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...

Latest from the lab by @longweibai.bsky.social
www.biorxiv.org/content/10.1...
1/6

Congratulations🥳🥳

Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...

Thank you, bro🙈🙈

Huge thanks to the whole Leulier's team for their support over the past four years😘😘

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

Very happy and proud to share the latest work from our lab.
Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

Very happy to share our latest lab publication!
The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators!
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...

An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...

Lastest work from Zhai's lab. mTORC1-mediated nutrient sensing orchestrates metabolic processes to maintain physiological homeostasis and influences organismal ageing in Drosophila.
www.biorxiv.org/content/10.1...

Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

Happy to share our new preprint! We explored the mechanisms underlying differences between male and female #Drosophila in susceptibility to intestinal #infection. #symbiosky
#immunity #AcademicSky #insect #symbiosis

Discovery of a gut hormone that regulates protein intake, sleep, and influences lifespan
www.nature.com/articles/s42... (open-access) @natmetabolism.nature.com
www.nature.com/articles/s42... in mice and flies

Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...

Happy to share our latest minireview on
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity journals.asm.org/doi/10.1128/...
#immunity #infection #antimicrobialpeptides #microbiome #Drosophila #AcademicSky #insect #endosymbiont #symbiosis

Glutamine-glutamate intercellular relay model for brain sparing

Our latest preprint…Adrien Franchet, Yuhong Jin et al @crick.ac.uk show that circulating glutamine drives brain sparing during nutrient restriction. Great collab with labs of Yaël Grosjean and Ian Gilmore.
#metabolism #Drosophila #neuralstemcells

www.biorxiv.org/content/10.1...

The lab will be represented at #Dros25.
@longweibai.bsky.social presenting in the Physiology session on Friday at 5pm after I give the intro to his talk in a plenary Thursday morning 😉.
#Drosophila #microbiome friends, let’s catch up and go see Longwei ´s talk he has a really cool story to share.

And enjoyed it even more when highlighting it in Cell Host Microbe
Free access link here:
authors.elsevier.com/a/1kbY9_hwRX...