Youran R Zhang

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Scratching exacerbates skin inflammation and enhances host defense against S. Aureus. And of course it’s all because of mast cells. Check out the new paper by Andrew Liu in the Kaplan lab. www.science.org/doi/10.1126/...

31.01.2025 00:54 — 👍 0    🔁 0    💬 0    📌 0

Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.

Thrilled to share my work at Science Translational Medicine! Glutamate receptor GluK2 is enriched in mast cells. Small molecule agonism suppresses mast cell response to MrgprB2/X2 ligands and reduces inflammation in murine models of contact dermatitis and rosacea www.science.org/doi/10.1126/...

12.12.2024 11:08 — 👍 2    🔁 0    💬 0    📌 0