Jose Areta

Overall: energy deficit + aerobic exercise may steer muscle toward a more oxidative and potentially more youthful phenotype. Proud of the team and excited for what’s next! 🚀

We also found reduced ECM and collagen-related proteins — a pattern previously linked to lower age-related fibrosis in monkeys, now shown in humans for the first time.

Despite clear signs of energy deficit (⬇️ leptin, IGF-1, T3), skeletal muscle didn’t simply “shut down.” Instead, it shifted toward a more oxidative profile — increasing mitochondrial proteins tied to quality control, β-oxidation, the Krebs cycle & ETC. 🔥

Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans After consecutive 5-day periods of energy balance and energy deficit (ED, 78% reduced energy availability—EA) including aerobic exercise, trained males experienced reduced fat and fat-free mass, alon...

Excited to share that our new paper is out in The FASEB Journal after years in the making! 🎉
“Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans.”

faseb.onlinelibrary.wiley.com/doi/10.1096/...

Could exercising while losing weight preserve your muscles and help keep them ‘young’? A new study has highlighted how remarkably resilient human muscle is.

What happens to your muscles when you lose weight and exercise?

Our new piece in @uk.theconversation.com explains how combining an energy deficit with training may have a positive effect on skeletal muscle

🔗 theconversation.com/could-exerci...

#MuscleHealth #ExerciseScience #WeightLoss #Research

Limited Empirical Support for Relative Energy Deficiency in Sport (REDs) Syndrome - Sports Medicine Sports Medicine -

Are you interested in the REDs debate?

Our 'Does REDs exist?' viewpoint has been criticised

link.springer.com/article/10.1...

To which we have replied

link.springer.com/article/10.1...

Please read both critically and draw your own conclusions

Openness guides discovery - Nature Biotechnology Nature Biotechnology - Openness guides discovery

Really interesting viewpoint on the evolution of research ideas and the importance of openness to guide discovery:

www.nature.com/articles/s41...

Exciting postdoc opportunity to come and join us at the Institute of Sport.

The Truth About Relative Energy Deficiency in Sport The risks of training while depleted are finally getting lots of attention—maybe too much

Nice to see our work showcased in
@outsidemag.bsky.social by Alex Hutchinson with an invitation to reflect on the important, but likely inflated, role of energy deficit in health and performance.

www.outsideonline.com/health/train...

Our article got ranked 3rd in the IJSNEM paper of the year 2024! Very happy to see our work on the podium

In vivo imaging of glycogen in human muscle - Nature Communications The non-invasive spatial measurement of glycogen in humans has been challenging due to a lack of sensitive approaches. Here, the authors characterize regional glycogen dynamics in human muscle under e...

Delighted to this see this work published in @naturecomms.bsky.social showing super high temporal and spatial resolution of muscle glycogen dynamics using new MRI technology.

Fascinating to see very heterogenous and complex dynamics of glycogen use and resynthesis.

www.nature.com/articles/s41...

Does Relative Energy Deficiency in Sport (REDs) Syndrome Exist? - Sports Medicine Relative energy deficiency in sport (REDs) is a widely adopted model, originally proposed by an International Olympic Committee (IOC) expert panel in 2014 and recently updated in an IOC 2023 consensus...

Are you interested in REDs and low energy availability?

Check out our latest work 'Does REDs exist?', which challenges the idea that low energy availability is the only etiological factor for the syndrome, and brings forward other possible explanations

link.springer.com/article/10.1...

As an international scholar, I’m learning to speak up—accent and all “My ideas matter more than how I sound,” this postdoc writes

www.science.org/content/arti...

There are further reasons why this work is relevant and new.

Fifth, sports science scientific literature is composed of about 6% female-specific research. There is little knowledge about sports nutrition of female athlete. This work expands this knowledge and supports further research to be conducted in female population.

Fourth, it shows that even though the athlete was following current dietary recommendations for athletes, she still faced a rather dramatic energy deficit.

Third, it's the first characterisation of the demands of a female grand tour and the characteristics of the nutrition of an athlete in this type of competition.

Second, it provides new insights into the capacity to perform at high level despite facing significant energy deficit. This is a highly debated topic for which there is little information.

Thank you for the comment. Not all research needs to be revolutionary to show something new. There are a few new things in this piece of work. I detail some here: For one, it is the highest level of energy expenditure reported in a woman, ever, with this state-of-the-art methodology.

Here is a link to a free full version of the article journals.humankinetics.com/view/journal...

IJSNEM Paper of the Year 2024

Our study 'Energetics of a World-Tour Female Road Cyclist During a Multistage Race (Tour de France Femmes)' published at @IJSNEMJournal got shortlisted for paper of the year 2024!!!

If you liked the paper, we need your support! give us a vote here:

docs.google.com/forms/d/e/1F...