Andrew

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Congrats to @ananya-p.bsky.social on her outstanding Master’s defense on #gdTcell migration! 🍾🎉 We’re looking forward to another couple of years with Ananya as she takes on the new role of senior grad student @sinaiimmuno.bsky.social 😁

two men are riding a bicycle with a basket on it . ALT: two men are riding a bicycle with a basket on it .

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social

a man in a suit and tie is standing next to a woman in a blue tank top and a man in a white shirt . ALT: a man in a suit and tie is standing next to a woman in a blue tank top and a man in a white shirt .

Congrats to co-first authors @weilix27.bsky.social and @nbgolovchenko.bsky.social on their fantastic achievement and hard work getting this project off the ground! Thanks to Irving for all the help in the revision process and the many labmates @andrewfong.bsky.social that contributed. 9/n

@sinaiimmuno.bsky.social just gained a rockstar #PhD student with the acceptance of @ananya-p.bsky.social! Come see why we’re so lucky that Ananya will be joining us for a few more years at the APS Summit. She’ll be presenting two flashtalks (#GIL Trainee Symposium & Forte) on #gdTcell #migration 😍

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Congratulations to Dr. Sara Alonso on a spectacular defense! 👏 🍾 Sara is a powerhouse of #gdTcell #immunometabolism data in the lab. We can’t wait to share the #preprint of her thesis work on #gdTcells and #microbiota with you later this week. @sinaiimmuno.bsky.social

Reminder to floss on #FluorescenceFriday just like this gamma delta IEL (pink)!