Communications Medicine

Adverse childhood experiences increase the long-term accumulation of morbidity in women - Communications Medicine Rocca et al. examine the effect of early-life adverse experiences, including early adulthood, on late-life morbidity using a cohort study in the US. The authors show that both adverse childhood experiences and abuse in childhood or early adulthood are associated with an accelerated accumulation of morbidity later in life.

🚨 NEW RESEARCH! ⚕️ 🩺

Rocca et al. show that adverse childhood experiences #ACEs are associated with an accelerated accumulation of morbidity later in life.

https://bit.ly/4l6vAJ2
#ChildAbuse #HealthOutcomes

The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study - Communications Medicine Lin et al. investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Four gut microbial species and microbial diversity associate with 24-h blood pressure traits, supporting a potential role for the gut microbiome in blood pressure regulation and variability.

🚨 NEW RESEARCH! ⚕️ 🩺

Lin et al. find a link between the gut microbiome and blood pressure regulation🫀

https://bit.ly/3UKlFOk
#GutHealth #heartHealth

Cancer Research Funding in Africa - Communications Medicine Afolaranmi et al. analyze data from four databases on funded cancer research projects in Africa, over a 20-year period. They report an increasing trend in cancer research funding; however significant disparities exist in regional distribution and cancer types funded, with over-reliance on external funders prominent in Sub-Saharan African countries.

🚨 NEW RESEARCH! ⚕️ 🩺

Afolaranmi et al. report on the trends in cancer research funding in Africa over 20 years, highlighting the regional disparities.

https://bit.ly/3UBKSKO
#HealthinAfrica #PublicHealth

Quality of life and mental health in children with long COVID - Communications Medicine Noij et al. assess health-related quality of life (HRQoL) and mental health in children with pediatric Long COVID (PLC) compared to children with chronic health conditions and the general population. They find that children with PLC report worse HRQoL and higher risks of severe anxiety, depressive symptoms, and sleep-related impairment.

🚨 NEW RESEARCH! ⚕️ 🩺

Noij et al. find that children with pediatric Long-COVID report worse health-related quality of life, particularly with mental health.

https://bit.ly/41j5zim
#PediatricHealth #LongCOVID

Feasibility of serial measurement of nitrite for pharmacodynamic monitoring and precision prescribing in urinary tract infections - Communications Medicine Stadler et al. evaluate the diagnostic value of urinary tract infection biomarker, nitrite, in predicting disease progression and treatment efficacy. The longitudinal measurement of nitrite in an in-vitro UTI distinguishes between amoxicillin-resistant and susceptible E. coli strains and correlates with bacterial colony-forming unit counts in-vitro and in clinical UTI.

🚨 NEW RESEARCH! ⚕️ 🩺

Stadler et al. evaluate the diagnostic value of #UTI biomarker nitrite in predicting disease progression and treatment efficacy.

https://bit.ly/4mguBqu


#HealthResearch

Influence of geomagnetic disturbances on myocardial infarctions in women and men from Brazil - Communications Medicine Rezende et al. analyze the link between geomagnetic activity and myocardial infarction hospitalizations in a city of Sao Paulo State, Brazil during 1998-2005. They find that disturbance in geomagnetic conditions that are due to solar activity increase myocardial infarction cases, particularly for women.

🚨 NEW RESEARCH! ⚕️ 🩺

Rezende et al. find that disturbances in geomagnetic conditions from solar activity increase myocardial infarction cases particularly for women🫀

https://bit.ly/458sfD8

#PublicHealth

Recent advances in CRISPR-based single-nucleotide fidelity diagnostics - Communications Medicine Kohabir et al. review recent advances in CRISPR-based diagnostics aimed at achieving single-nucleotide fidelity for clinical applications. By dissecting strategies in gRNA design, effector selection, and reaction conditions, the authors highlight how these innovations can support precise and accessible genetic testing at the point-of-care.

🚨 NEW REVIEW! ⚕️ 🩺

Kohabir et al. explores recent strategics aimed at refining CRISPRdx specificity for SNV detection to broaden applicability and improve precision detection of CRISPRdx in diverse clinical settings.

https://bit.ly/3TY2sbW

#CRISPR

🚨 NEW COMMENT! ⚕️ 🩺

Imani-Musimwa et al. highlight the causes, as well as the challenges and strategies needed to curb the spread of the current uncontrolled Mpox outbreak in the Democratic Republic of Congo.

https://bit.ly/3IKWJUn #Mpox #DRCongo

Towards individualised treatment of urinary tract infections - Communications Medicine Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.

🚨 NEW COMMENT! ⚕️ 🩺

Stadler et al. highlight the potential of longitudinally monitoring biomarkers in urine using existing technologies to enable individualized PK-PD optimization in urinary tract infections.

Long-term spatial patterns in COVID-19 booster vaccine uptake - Communications Medicine A key line of defence against many infectious diseases is vaccination, and it is especially important to vaccinate people at the highest risk of becoming seriously unwell if infected. For COVID-19, this includes (amongst others) the elderly and people living in more deprived areas. Looking at Scottish vaccine data and comparing it to data on how deprived different areas in Scotland are, we show how uptake has dropped off in some of these at-risk groups. This is different from the early stages of the pandemic, when there was more motivation to get vaccinated so life could get back to normal. This is concerning because, although we are no longer in a pandemic, COVID-19 continues to circulate in high numbers, and the protection offered by a COVID-19 vaccine is relatively short-lived. The findings of this study suggest that those at-risk groups should be specifically targeted for booster vaccinations moving forward.

🚨 NEW RESEARCH! ⚕️ 🩺

Wood et al. utilize Scottish vaccine data to understand how uptake has dropped off in some at-risk groups and highlight who should be specifically targeted for booster vaccinations moving forward.

AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models - Communications Medicine Novak, Lin et al. use AI computational drug prediction and CRISPR-enabled in vivo disease modeling to identify therapeutic strategies for the treatment of Rett syndrome. Findings reveal the…

Wyss researchers used an AI-enabled drug discovery approach to identify a potentially game-changing treatment for Rett Syndrome, which has been advanced from the lab bench to an FDA Orphan Drug Designation in record time. This work was published in @commsmed.nature.com.

A comprehensive overview of the burden, prevention, and therapeutic aspects of arboviral diseases in India - Communications Medicine Gupta et al. discuss the epidemiology and burden of major circulating arboviral diseases in India, touching on diagnosis, treatment, and preventative measures. They highlight key research and policy gaps, along with direction for future research, to improve surveillance and control measures.

🚨 NEW REVIEW! ⚕️ 🩺

Gupta et al. explores current literature surrounding major arboviruses in India and advancements in diagnosis, treatment protocols, supportive care, and the development of preventive measures.

https://bit.ly/44Z075B #Arboviruses

Development and multicenter validation of on-site breast cancer diagnosis using paper spray ionization miniature mass spectrometry - Communications Medicine Huang, Chung et al. develop the MiniMaP platform, a miniature mass spectrometer coupled with paper spray ionization, enabling rapid breast cancer diagnosis from core needle biopsy samples. The machine learning model trained on molecular profiles maintains consistent accuracy in multi centre validation.

🚨 NEW RESEARCH! ⚕️ 🩺

Huang et al. developed the MiniMaP platform, a small mass spectrometer designed for rapid breast cancer diagnosis, capable of quickly analyzing the molecular composition of tissue samples.

Overcoming data scarcity in life-threatening arrhythmia detection through transfer learning - Communications Medicine Monachino et al. investigate how to overcome the challenge of data scarcity in life-threatening arrhythmias (LTA) detection. They propose a transfer learning-based deep learning model that detects LTAs from single-lead ECGs with 92.68% sensitivity and 99.48% specificity and includes a confidence score to better support emergency response.

🚨 NEW RESEARCH! ⚕️ 🩺

Monachino et al. propose a deep-learning model that uses large dataset of general cardiac signals and subsequently adapts to smaller datasets specific to life-threatening arrhythmia cases.

Hydrogen sulfide aggravates neutrophil infiltration, vascular remodeling and elastase-induced abdominal aortic aneurysm in male mice - Communications Medicine Bechelli et al. evaluate the effect of sodium thiosulfate (STS), a hydrogen sulfide donor, on abdominal aortic aneurysm (AAA) progression in normotensive mice. They see neutrophil-driven matrix degradation, vascular smooth muscle cell senescence and accelerated development of AAA.

🚨 NEW RESEARCH! ⚕️ 🩺

Bechelli et al. investigated whether sodium thiosulfate (STS), a H₂S-releasing compound, could reduce abdominal aortic aneurysm progression in mice finding this compound worsened the condition.

Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments - Communications Medicine Patel et al. explore serum metabolomic differences in PCOS women from urban and rural India. Rural women show higher lipid-related metabolites like Palmitone, while urban women exhibit altered carbohydrate and nucleotide metabolism, likely due to processed food consumption. These findings highlight the impact of lifestyle on PCOS metabolism.

🚨 NEW RESEARCH! ⚕️ 🩺

Patel et al. find differences in serum metabolomics between rural vs. urban women with #PCOS.

https://bit.ly/46ANpMA

#WomenHealth #PolycysticOvarySyndrome

Obesity This cross-journal collection welcomes submissions of clinical and preclinical work that explores all aspects of obesity, including causes, pathophysiological ...

Our joint collection w/ @commsmed.nature.com, @natcomms.nature.com, Nature Medicine and Nature Metabolism welcomes submissions of clinical & preclinical work that explores all aspects of obesity, including causes, pathophysiological mechanisms & more.

Read more here 👇
www.nature.com/collections/...

Optimal timing for atrial fibrillation patients to undergo catheter ablation - Communications Medicine Lin et al. investigate the impact of diagnosis-to-ablation timing on atrial fibrillation (AF) recurrence after catheter ablation. This study finds that early catheter ablation, characterized as diagnosis-to-ablation in less than 3 years, is preferable for maintaining sinus rhythm, particularly in persistent AF.

🚨 NEW RESEARCH! ⚕️ 🩺

Lin et al. identify the optimal timing for atrial fibrillation patients to undergo catheter ablation as less than 3 years. 🫀

https://bit.ly/3GrWI75
#HeartHealth #CatheterAblation

🚨 NEW RESEARCH! ⚕️ 🩺

Kuwahara et al. show that maintaining or improving healthy lifestyles is linked to a lower risk of developing prediabetes in a large Japanese cohort.

https://bit.ly/4eZ1YvT
#DiabetesPrevention

Temporal trends of blood-based markers in various psychiatric disorders and their cross-sectional brain structure associations - Communications Medicine Wang, Zhou et al. conduct a nested case-control study within the UK Biobank cohort to investigate the temporal trends of blood-based biomarkers across major psychiatric disorders. They report significant temporal alterations in biomarkers and their associations with cross-sectional structural variations in specific brain regions, highlighting disease-specific neurobiological correlates.

🚨 NEW RESEARCH! ⚕️ 🩺

Wang, Zhou et al. identify temporal trends of blood-based #biomarkers across major psychiatric disorders that are potentially linked to earlier diagnosis and better treatment outcomes.

https://bit.ly/3Gqi194
#Psychiatry

Determining frailty index thresholds for older people across multiple countries in sub-Saharan Africa - Communications Medicine Dzando et al. identify locally relevant frailty thresholds for older people in Sub-Saharan Africa through Receiver Operating Characteristic analysis and random-effects meta-analysis. Findings demonstrate variability in population level thresholds with a pooled threshold of 0.29 demonstrating good sensitivity and specificity across the populations.

🚨 NEW RESEARCH! ⚕️ 🩺

Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries.

https://bit.ly/44QDcdy

#FrailtyResearch

Healthy Aging This collection welcomes submissions based on studying preclinical models, as well as population-wide and clinical studies. Studies that advance our ...

💡 NEW COLLECTION on Healthy Aging!

Click here to learn more:

https://bit.ly/4kuQIbE

#HealthyAging

High tumor expression of CTLA4 identifies lymph node-negative basal-like breast cancer patients with excellent prognosis - Communications Medicine Røssevold et al. identify a subset of patients with early-stage basal-like breast cancer with an excellent prognosis, defined by high tumor expression of the immune checkpoint gene CTLA4. These patients are currently considered high-risk and receive extensive systemic treatment, which the authors suggest could safely be de-escalated or omitted.

🚨 NEW RESEARCH! ⚕️ 🩺

Røssevold et al. find that basal-like breast cancer patients with high levels of the immune-related gene CTLA4 in tumor had less recurrence after initial treatment and excellent prognoses.

https://bit.ly/45R95DZ #BreastCancer #CTLA4

PERSPECTIVE ⚕️ 🩺

Alimohamed et al. discuss the economic benefits of adopting pharmacogenomics implementation in Africa and the impact on healthcare cost drivers.

https://bit.ly/3ToeJpC #Pharmacogenomics #HealthEconomics #AfricaHealth

Towards individualised treatment of urinary tract infections - Communications Medicine Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.

COMMENT ⚕️ 🩺

Stadler et al. highlight the potential of real-time pharmacokinetic-pharmacodynamic (PK-PD) monitoring of urine biomarkers for individualized treatment of UTI.


https://bit.ly/3GufoTw
#PersonalizedMedicine #UrinaryTractInfection

Forging a novel therapeutic path for patients with Rett Syndrome using AI By Benjamin Boettner (BOSTON) — Rett syndrome is a devastating, rare genetic childhood disorder primarily affecting girls. Merely 1 out of 10,000 girls are born with it, and much fewer boys. It is cau...

Wyss researchers identified a drug known as vorinostat as a promising treatment for Rett syndrome, demonstrating disease-modifying abilities across multiple neuronal and non-neuronal tissues in preclinical models. This work was published in @commsmed.nature.com. #RettSyndrome #RareDisease

Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans - Communications Medicine Bernaquez et al. investigate the genomic epidemiology of a cluster of extensively drug-resistant Salmonella enterica serovar 4,[5],12:i:- ST34 affecting Canadians and cattle following the acquisition of an IncHI2A plasmid. Findings reveal dogs fed raw meat-based diets as the main source of transmission in young infants.

🚨 NEW RESEARCH! ⚕️ 🩺

Bernaquez et al. characterize an outbreak of Salmonella using genomics and epidemiology. Feeding raw meat-based diets to dogs increased disease risk, particularly in young children.

https://bit.ly/45TFb1Q
#Epidemiology #Salmonella

Pretrained patient trajectories for adverse drug event prediction using common data model-based electronic health records - Communications Medicine Kim et al., develop an adverse drug event (ADE) prediction model using language model-based electronic health records (EHR) pretraining model. Authors show that EHR pretraining models can accurately predict ADEs with proper explanations.

🚨 NEW RESEARCH! ⚕️ 🩺

Kim et al. present an AI model to predict potential adverse events due to prescribed medications, using data from EHRs.



https://bit.ly/4kpwxfc #AI #Healthcare #EHR #DrugSafety

Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions - Communications Medicine Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The co...

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @commsmed.nature.com. We benchmarked a set of PGS for cardiovascular traits available from the pgscatalog.org resource in different Canadian cohorts🍁.

See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...

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High tumor expression of CTLA4 identifies lymph node-negative basal-like breast cancer patients with excellent prognosis - Communications Medicine Røssevold et al. identify a subset of patients with early-stage basal-like breast cancer with an excellent prognosis, defined by high tumor expression of the immune checkpoint gene CTLA4. These patien...

📍 High tumor expression of CTLA4 identifies lymph node-negative basal-like breast cancer patients with excellent prognosis
📰 Published in @commsmed.nature.com
🤝 Reused data: EGAS00000000083
👉 www.nature.com/articles/s43...