D. the /^[Ll]o[вwv]o?l$/ Lowl

That's so fascinating.

D. Lowl (@dlowl) I ran out of coffee at home the other day. So I was rather glad that I picked up some specialty instant coffee at the Manchester Coffee Festival. I’ve never tried specialty instant, and was very curio...

substack.com/@dlowl/note/...

I ran out of coffee at home the other day. had specialty instant coffee from MCF though. I’ve never tried specialty instant before. We had a cup of each. They were alright. The Kenya was a touch brighter, but generally pleasant cups. They still had this instant coffee taste to them. Gotta try more

I created a Minute Cryptic for you to solve: Waffle maker from five but four, periodically (4)
Give it your best shot!
www.minutecryptic.com/custom/94259...

Ты зачем у меня идею из головы украл

Spotify add music to other people’s queue

Untitled Myco-Structure (speculative origin)
Monochrome print, 2020.

Believed to capture the moment when matter begins to think, this image records a fungal network unfolding across an unseen plane. Some claim it is a laboratory artifact; others, a self-portrait of information learning how to grow

I don't know much enough multi-modal models though, to claim that it'd work.

I do think that representing scRNAseq data in this rank-order way may be constrained. (As it gets rid of a lot of information). It would be interesting to train a multi-modal model with inputs like:
- DNA/RNA seq
- Protein seq
- scRNAseq/HiSeq data
- structural data
then we are def talking

I know wanna see whether I can replicate the our Interdependence Coefficient/Modes paper findings, e.g. if I feed it a bunch of neurons scRNAseq, will it be able to detect Protocadherins as exclusively expressing. Here goes my Sunday I guess.

How does it do with genes of naturally low expression (also what units are used for ordering of genes? some normalisation techniques will result in different orders)

Does it only support only one gene naming convention?

Does it model "on/off" gene state well enough?

It's also not always true that if exp(A) > exp(B) and A is downregulated -> B is downregulated.

Basically counts mean different things for different genes.

It's literally a text generation model, which was fine tuned on "cell sentences" -- space-separated gene names ordered by descending expression. Claims to be able to do quite a few things at inference (see the diagram)

I wonder about a few things though:

How a Gemma model helped discover a new potential cancer therapy pathway We’re launching a new 27 billion parameter foundation model for single-cell analysis built on the Gemma family of open models.

There are some cool news about Gemma fine-tuned model used to find new potential cancer therapy pathway: blog.google/technology/a...

I found the model itself to be quite interesting too: huggingface.co/vandijklab/C...

OCD isn’t about being neat "OCD isn’t about being neat" kind of post, since this is OCD Awareness Week.

"OCD isn’t about being neat" kind of post, since this is OCD Awareness Week

I thought I was just a very anxious person. I was working on my "anxiety" for a few years now. Earlier this year I had a particularly bad episode, which led me to being diagnosed with OCD.

open.substack.com/pub/dlowl/p/...

There are still more shows here in Manchester for a week or so, and then she's going for a tour.

This is exactly how Marina Abramovich's ‘Balcan Erotic Epic' felt like. At first, I tried to perceive it as an exhibition, but it seemed cheesy. Looking at it as a very abstract theatrical performance on the other hand... Loved it a lot.

Say, you're going to Serbia or Bosnia for a weekend. You're planning to meet some friends, enjoy the local nature, eat some ćevapi, maybe visit a cemetery.
But then you get a nasty flu. To not waste the trip, you still do everything you planned, but in a state of basically a fever dream.

Да

That blows my mind.

The time has come

Hollow Knight: Silksong

Anyone in Manchester needs a ticket Arch Enemy (Oct 31) or Manchester Coffee Fest (Nov 15-16)? I've got some I no longer need. Hit me up for MCF. Arch Enemy is here secure.ticketmaster.co.uk/rs/36006175A...

Save 10% on Strange Antiquities on Steam Become the custodian of a store dealing in occult antiquities. Explore the quaint and gloomy town of Undermere, where strange goings-on and dark mysteries abound. Find and identify arcane artefacts, u...

Strange Antiquities is out! It's the sequel to Strange Horticulture, which is a fantastically atmospheric puzzle / mystery / plant game. Big recommend from me:

Photo of square orange tiles, set into the ground, across one of which several cats footprints are clearly visible.

One day, nearly 2000 years ago, a cat dashed across some drying tiles, somewhere near Hadrian's Wall.

It's immortality of a kind, isn't it?

A white cat sleeping in a store box filled with catnip.

Lost in the sauce.

I want to be a fern when I grow up

A wall. On the left: a poster "CMAT The new album EURO-COUNTRY 29.08.25" It pictures a woman on a blue dress in the sky, holding a large 1 euro coin made into a solar symbol. On the right: a poster "Deftones Private music" It pictures a white snake on a plain green background. In the centre, a rusty rolling door with a bunch of tag graffitis