王廷方Ting-Fang Wang

Supplement trio shows promise in reversing autism-linked behaviors in mice Researchers led by Tzyy-Nan Huang and Ming-Hui Lin from Academia Sinica in Taiwan report that a low-dose mixture of zinc, serine, and branch-chain amino acids can alleviate behavioral deficits in thre...

www.eurekalert.org/news-release...

I was privileged to work closely with Meng-Chao during my early years as a junior PI at Fred Hutch. We worked on centromeric histones and chromosome dynamics. He fundamentally shaped how I think about genome organization. His mind was brilliant, his rigor uncompromising, his generosity boundless. 2/

Meng-Chao Yao Obituary | 1949 - 2025 | Seattle Times View Meng-Chao Yao's complete obituary, share memories, and explore 1 tribute posts from the community.

Deeply saddened by the passing of my colleague, Prof. Meng-Chao Yao, a remarkable scientist and mentor. He left an indelible mark on all of us fortunate enough to know him. His legacy in molecular and ciliate biology will endure. Rest well, my friend. 1/

obituaries.seattletimes.com/obituary/men...

Figure 1. During homeologous recombination, homologous recombination (HR) proteins antagonize mismatch repair (MMR) in several homology-directed double-strand break (DSB) repair steps, including D-loop formation, capture of the second processed DSB ends, and formation of ZZM-dependent class I crossover (CO) products.

"Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity"
by Ting-Fang Wang (@tingfangwang.bsky.social) & Ji-Long Liao (廖吉隆)

"We postulate that counter-actions of MMR and HR contribute to the post-zygotic isolation..."

authors.elsevier.com/sd/article/S...

Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes - PubMed Rad51 and meiosis-specific Dmc1 catalyze homologous recombination (HR) between maternal and paternal chromosomes during meiosis in many sexual eukaryotes, generating three interhomolog (IH) recombinat...

New meiosis and DNA repair paper
pubmed.ncbi.nlm.nih.gov/40902007/

My postdoctor Lavernchy Jovanska (Indonesia) registered ECFG2025. She can't get travel visa to enter Ireland because the visa Department is still processing visa applied before 30th October, 2024. It is a pity that ECFG2025 refuses to refund her registration fee.

Reconstitution of SPO11-dependent double-strand break formation - Nature Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the re...

Also see two accompanying papers by the labs of Scott Keeney and Ming-Han Tong reporting similar findings, focusing on the SPO11-TOP6BL complex.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

And here is a nice News&views by Mendez Diaz and Corbett.
www.nature.com/articles/d41...

Shared Alteration of Whole-Brain Connectivity and Olfactory Deficits in Multiple Autism Mouse Models https://www.biorxiv.org/content/10.1101/2025.02.02.636175v1

pubmed.ncbi.nlm.nih.gov/39706365/

Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes

www.imb.sinica.edu.tw/ch/research/...

Does “Chromosome Envelope” Exist in Addition to the Cell Membrane and Nuclear Envelope?

Shared Alteration of Whole-Brain Connectivity and Olfactory Deficits in Multiple Autism Mouse Models Autism spectrum disorder (ASD) is a disconnection condition influenced by both heterogeneous genetic and environmental factors, yet it remains unclear whether common connectivity deficits exist. Here,...

Shared Alteration of Whole-Brain Connectivity and Olfactory Deficits in Multiple Autism Mouse Models www.biorxiv.org/content/10.1...

A lose for science.

Signaling in autism: Relevance to nutrients and sex - PubMed Autism spectrum disorders (ASD) are substantially heterogeneous neuropsychiatric conditions with over a thousand associated genetic factors and various environmental influences, such as infection and ...

A new review is just published

pubmed.ncbi.nlm.nih.gov/39731919/