Jingli Cao Lab

Thank you for the shout out! We are hiring a postdoc to study heart development and regeneration using zebrafish and human cardiac organoids. Refer to caolab.net and email me!

🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶

For more details see here research.chusj.org/RECHERCHE/fi...

I am thrilled to release our latest preprint from @amilangscience.bsky.social, out today @ biorxivpreprint!

Local erythropoiesis directs oxygen availability in bone fracture repair.

biorxiv.org/cgi/content/...

A paper thread:

Calling all cardiovascular scientists.... @WeinsteinConf is in Milwaukee May 14-16! Abstract submission now open. Registration portal is imminent!

childrenswi.org/weinstein

Are you a trainee and want to be considered for a platform talk - abstract due Feb 21!

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...

Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Timely TGFβ signalling inhibition induces notochord - Nature Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.

Our latest: how to generate the notochord
"Timely TGFβ signalling inhibition induces notochord"

A thread:

www.nature.com/articles/s41...

How can some vertebrates naturally recover from deafness?

In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...

Zebrafish glial-vascular interactions progressively expand over the course of brain development Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

And somehow I missed it going live last week 😂 - our #zebrafish glial-vascular paper is available for those finterested! One of the best ways to end 2024 as a #newPI www.cell.com/iscience/ful...

Drawing of an adult male zebrafish. You can see the attention to detail in the scales.

Meticulous drawing of an adult zebrafish. Credit to @jacsciart.bsky.social. #ZebrafishZunday 🧪

Congrats Caghan! Beautiful work!

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system - Nature Communications Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...

🚨 Our new study out in @natureportfolio.bsky.social! 🌟
We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟

More about how this changes what we know about heart functionality.
#Zebrafish #Neuroscience #LittleBrain

doi.org/10.1038/s414...

Congrats Ruben and the team! Great to see its publication. Beautiful work!

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response Summary: flt1 inactivation promotes zebrafish cardiac regeneration by enhancing coronary revascularization and endocardial expansion, while limiting myofibroblast differentiation.

And it's finally out! Very happy to share or latest work.
This has only been possible thanks to the tremendous work and commitment of Zhenyu, Armaan and all the co-authors. We hope you find it interesting!

journals.biologists.com/dev/article/...

Thanks Ruben! Great to see your Dev paper in print. Beautiful work!

Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury - Communications Biology Dynamic cross-species single cell transcriptomic analyses reveal conserved and disparate cardiac and extracardiac inflammatory responses upon heart injury between models with fibrotic and regenerative...

2 papers in a row! We have new story published in Communications Biology. Working with James Lo and Doron Betel labs at Weill Cornell, we jointly revealed disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury. www.nature.com/articles/s42...

Thank you Sofia!