@gauntgroup.bsky.social
Synthesis. Catalysis. Biology. Technology. Research group @cambridge-uni.bsky.social. Student-run account. Formal enquiries should be directed to MJG.
Congrats to Marcus on this years-long effort. Read it at doi.org/10.1038/s41586-025-09159-9
#ChemSky βοΈπ§ͺ (3/3)
Scheme showing a chemical reaction from Cyclosporin A to homo-Cyclosporin A. The novel one carbon homologation acts on the internal alkene in the WHO essential medicine Cyclosporin A and homologates it to give a novel analog with unexplore properties.
Our methodology demonstrates broad applicability across a diverse range of highly functionalised alkene substrates. It homologates terminal and internal alkenes and complex molecules like Cyclosporine A, enabling the synthesis of analogs with modified βbiological properties. (2/3)
22.05.2025 10:08 β π 3 π 0 π¬ 1 π 0
Scheme showcasing and explaining the novel one-carbon alkene homologation. An (allyl)siloxymethylsulfone reagent is attached to the alkene via cross metathesis, deprotected via acid-mediated fragmentation to the sulfinic acid, and undergoes the retro-ene to deliver the homologated alkene. This reaction works across a broad scope of simple and complex alkenes, including monosubstituted, 1,1-disubstituted and 1,2-disubstituted internal alkenes.
Excited to share that our one-carbon alkene homologation has been published in @nature.com. π Marcus developed a simple reagent that enables the homologation of alkenes by a one-pot cross metathesis-fragmentation-retro-ene cascade giving easy access to the homologated alkene. (1/3) π§΅
22.05.2025 10:08 β π 5 π 1 π¬ 1 π 0
Happy to see our Carbonyl Azinylative Amination highlighted in @acs.org OPR&Ds new items of interest. Alex, Roopender and Rachel's work uses in situ generated heteroarylindium species to form diverse heteroarylaklyamines from three readily available starting materials.
pubs.acs.org/doi/10.1021/...
Find this work at pubs.acs.org/doi/10.1021/...
16.12.2024 23:38 β π 2 π 0 π¬ 0 π 0
A graphic showing a central chemical structure of a palladium-coordinated central N-alkyl piperidine which then undergoes either productive Ξ³-C-H cleavage or decomposition via Ξ²-H elimination. DFT structures highlight how an N-Ac amino acid ligand favours the productive Ξ³-C-H cleavage due to geometic restriction around the Pd-centre. Find this work at https://pubs.acs.org/doi/10.1021/acscatal.4c06160
Check out our new work in 3Β° alkylamine directed #Pd catalysed C-H activation in #ACSCatalysis. Jesus shows how an amino acid ligand favours one CMD pathways to preferentially give Ξ³-C(sp3)-H actiavtion over Ξ²-H elimination enabling us to make some strained 4Β° centres.
#ChemSky π§ͺβοΈ
We are thrilled to see our recent work on carbonyl acylative amination be highlighted in #OPRD. Congrats once more to our colleague Dr. Jianzhong Liu, who is starting his own lab at the University of Science and Technology of China (USTC).
#ChemSky βοΈπ§ͺ
pubs.acs.org/doi/10.1021/...
A celebration in the Gaunt Group's lab kitchen including Matthew Gaunt and the newly graduated Dr. Joe Phelps.
Congratulations on Dr. Joe Phelps for passing his viva ππ!!
#ChemSky π§ͺβοΈ
