Gesa Freimann

Very excited to share this article written with my PhD advisor @hassansalem.bsky.social, highlighting the amazing work on organ remodeling for symbiosis by Nishino et al @fkttkm.bsky.social. A fascinating system to think about!

Wenn's dir nicht gefällt, mach neu: Der Wechsel von Real Scientists DE von X zu Bluesky. Jetzt kommen zwei der Organisatorinnen von @realscientists.de auf die Bühne. @sophieelschner.bsky.social und @scicommlena.bsky.social. Wer das Projekt nicht kennt - unbedingt folgen #wisskon25

Science in 2050: the future breakthroughs that will shape our world — and beyond Nuclear fusion. People on Mars. Artificial general intelligence. These are just some of the advances that could come by the mid-century mark.

A feature in Nature examines what could come in science before 2050, including nuclear fusion and people on Mars. 🧪

MONDE·T: A Database and Interactive Webserver for Non-Canonical Amino Acids (ncAAs) in the PDB Summary Non-canonical amino acids (ncAAs) are understood as amino acids that are not genetically encoded. They are of wide interest for protein design and applications in pharmaceutical and cell biolo...

I am so excited that MONDE·T is out!

Alex and I worked so hard on this database and webserver to make it easy for everyone to work with ncAAs.

-> mondet.tuebingen.mpg.de

It was a please for me to collaborate on that project with you, Alex 🥰 For many more to come.

www.biorxiv.org/content/10.6...

Is human limb regeneration science fiction? 🤯 What if the oxygen we breathe suppresses our ability to regenerate? @canaztekin.bsky.social busts myths and reveals the potential of regeneration. Watch the video: www.fml.tuebingen.mpg.de/71433/videos #BiologyMyths

We’re renewing our collaboration with Google DeepMind!

We'll keep developing the AlphaFold Database to support protein science worldwide 🎉

To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.

www.ebi.ac.uk/about/news/t...

🖥️🧬 #AlphaFold
@pdbeurope.bsky.social

Stability vs flexibility: reshaping archaeal membranes in silico

This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO

Webinar Special Edition: Summer School 2025 poster prize winners (2025-09-23) Date: 23 September 2025 Time: 15:00 CET Registration This special edition of the BioExcel webinar series features student speakers who were awarded poster prizes at the BioExcel Summer School 2025. R...

🔔 Don't forget to register for our special edition webinar on 23 September where we will have 3 interesting talks by our BioExcel Summer School 2025 poster prize winners:

Find out more and register here ➡️ bioexcel.eu/ion8

This is figure 1, which shows MNP exposure and cellular effects.

There are strong indications that micro- and nanoplastics exposure negatively impacts human health, but a robust evidence base is lacking. A Review in Nature Medicine focuses on the current state of the science. go.nature.com/47H9Q3s #medsky 🧪

Reminder: We want to hear *your voice* on taboos in women's and gender diverse health! 💬🧠Your perspective will directly inform priorities in research and a women's health resource platform. Find survey link at our website: www.cbs.mpg.de/cbs/en/resea...

📢Our next webinar is a special edition featuring the BioExcel Summer School 2025 poster prize winners

🗓️ Join us on 23 September at 15:00 CET
✍️ Registration and further information ➡️bioexcel.eu/ion8

Find out more about our speakers and their research...

One-shot design of functional protein binders with BindCraft - Nature BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

Nature research paper: One-shot design of functional protein binders with BindCraft

go.nature.com/46bhOAv

Zu sehen ist ein Teil der Ausstellung, mit Leuchtschriftzügen wie "Oxytocin" und bunten Lampen an der Decke

Was passiert, wenn Hirn, Herz und Hormone aufeinandertreffen? Das zeigt die Ausstellung „LIEBE.“ im Universum Bremen. Die wissenschaftliche Leiterin Dr. Kerstin Haller erläutert, wie die Liebe jenseits gängiger Klischees vermittelt wird. www.wissenschaftskommunikation.de/so-wird-lieb... #Wisskomm

Mykorrhiza: Wie Pilze und Pflanzen zusammenarbeiten Pilze und Pflanzenwurzeln verbindet eine enge Gemeinschaft: In ihrer Mykorrhiza-Symbiose tauschen sie lebenswichtige Nährstoffe aus.

#Pflanzen und #Pilze arbeiten eng zusammen - und sie profitieren beide! 🤗 Wie diese #Symbiose funktioniert, erklärt Caroline Gutjahr in diesem Podcast 🎙️https://detektor.fm/wissen/forschungsquartett-mykorrhiza #Mykorrhiza @detektorfm.bsky.social @mpi-mp-potsdam.bsky.social @carogutj.bsky.social

This summer school was so much fun! I feel honored to be selected as a speaker at the BioExcel webinar 🎤🎤☺️

Day 4 of the Summer School 2025 was about workflows and protein structure prediction

Adam Hospital introduced BioExcel Building Blocks #BioBB and followed up with a hands-on #tutorial on how to perform protein-ligand complex #moleculardynamics in Jupyter notebooks using BioBB

Day 3 of the Summer School is about enhanced sampling and free energy calculations⚡️

Berk Hess introduced the AWH method implemented in #GROMACS and illustrated its application to alchemical transformations where the main challenge is to define a good reaction coordinate

First full day of the Summer School on Biomolecular Simulations 2025 in Sardinia 😎 🏖️

It's mostly about #moleculardynamics and #GROMACS with lectures and hands-on tutorials

Check out these useful MD tricks from Prof. Berk Hess👇

Fantastic Proteins, Fantastic Team, Fantastic Diversity Day! 🪄

At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪

Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️

A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...

@mpi-bio-fml.bsky.social

209 new entries in #PDBrelease (http://PDBe.org/latest)! Here's the cryo-EM derived structure of a photosystem II complex with a Lys317Ala mutation that reveal new insights into proton egress through the conserved chlorine (Cl1) hydrogen-bonding channel (http://PDBe.org/9eh5).

Structural pathway for PI3-kinase regulation by VPS15 in autophagy The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and -C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzy...

Cook, Chen, Nguyen, Claveras et al. used #CryoEM ❄️& #moleculardynamics 💻 to crack the activation code of this essential complex. Read more here: www.science.org/doi/10.1126/...

PDB101: Molecule of the Month: Assembly Line Polyketide Synthases Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner.

January's Molecule of the Month on Assembly Line Polyketide Synthases
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner. Column by @janetiwasa
pdb101.rcsb.org/motm...

YouTube video by MPI for Biology & Friedrich Miescher Laboratory Plant Pathogen Evolution: Bananas

Is your favourite fruit at risk?🍌
Watch & learn from Dr. Honour McCann @honour.bsky.social as she dives into the impact of the pathogen Ralstonia syzygii on banana plantations in our new video.
For more on #PlantPathogen #Evolution, visit: www.bio.mpg.de/48883/plant-pathogen-evolution-honour-mccann

📣Please share: we're hiring a 𝗧𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝗔𝘀𝘀𝗶𝘀𝘁𝗮𝗻𝘁 (75%-100%) for the Friedrich Miescher Laboratory (FML) of the Max Planck Society. For an overview of the tasks, our requirements for the role and to apply: jobs.tue.mpg.de/jobs/241
Deadline 15 January 2025

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.

www.biorxiv.org/content/10.1...

Applications are now open for fully-funded #PhD positions at the Max Planck Institute for Biology and Friedrich Miescher Laboratory. The new cohort starts September 2025.

Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS

MDRepo—an open data warehouse for community-contributed molecular dynamics simulations of proteins Abstract. Molecular Dynamics (MD) simulation of biomolecules provides important insights into conformational changes and dynamic behavior, revealing critic

If you've ever thought to yourself "self, I wish there was a place that I could share all my molecular dynamics (MD) simulations, to support findability and re-use", I have great news!

I present to you: MDrepo, an open repository of MD simulations for proteins:

academic.oup.com/nar/advance-...