Mycoses Study Group Education & Research Consortium

Table of recommendations part 1

Table of recommendations part 2

Fungal diagnostic stewardship in immunocompromised populations: a focus on molds and dimorphic fungi

@jmsteinbrink.bsky.social @hannah-imlay.bsky.social et al on behalf of @msgerc.bsky.social

journals.asm.org/doi/10.1128/... #IDSky #MedMycoSky #MicroSky #TxID

Our new review article on #iatrogenic #mold #cns #infections #IDSky #MedSky @msgerc.bsky.social journals.asm.org/doi/10.1128/...

Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin α3β1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1α (HIF1α) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-βD-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyte–macrophage colony-stimulating factor (GM-CSF) and IFN-γ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue …

Risk factors for Mucormycosis

Risk factors for mucormycosis continued

Mucormycosis

Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh

www.nejm.org/doi/10.1056/...

#IDSky #TxID #MedMycoSky @msgerc.bsky.social

Free interactive training on neglected fungal diseases

👇👇

www.train.org/cdctrain/cou...

On behalf of @efisg_escmid

👇👇

gbr01.safelinks.protection.outlook.com/?url=https%3A%…

One Health approach requires collaboration between researchers, physicians, engineers, ecologists, plant health experts, and other disciplines to tackle the spread of mycoses.

Potential applications of AI in Mycology may include compound screening for antifungal drug discovery (top left), clinical trial design and execution (bottom right), fungal identification (top right), and outbreak surveillance (bottom right).

Emerging Frontiers in Clinical Mycology: Innovations, Insights, & Impacts

Our report, led by @annaapostolopoulou.bsky.social, on the cutting edge of clinical mycology & future directions, from expert discussion @ the 2024 @msgerc.bsky.social biennial meeting

onlinelibrary.wiley.com/doi/10.1111/...

Emerging Frontiers in Clinical Mycology: Innovations, Insights, and Impacts The Mycoses Study Group Education and Research Consortium (MSGERC)—a group comprising clinicians, researchers, patients, and industry partners—meets every 2 years to review the most significant chall...

Where is the field of #medical #mycology heading? Great write up by @msgerc.bsky.social #IDSky onlinelibrary.wiley.com/doi/10.1111/...

Welcome! You are invited to join a webinar: Testing Rationally in Mycology: Using Fungal Diagnostics to Drive Better Antifungal Decisions Webinar. After registering, you will receive a confirmation em... Join us as we explore practical, evidence-based approaches to fungal diagnostic testing and how to apply results effectively in clinical decision-making. Discussants will review the indications, stren...

msgerc.wildapricot.org/EmailTracker...

New webinar on fungal diagnostics!

Link in next post

Sign up here 👇👇

MSGERC is pleased to announce its fifth Biennial meeting!

We cordially invite you to this educational event for those seeking to diagnose, prevent, treat, and cure invasive fungal infections.

9-11 September 2026 in beautiful Colorado

PEDIATRIC MOLD INFECTIONS: WHAT’S NEW? - Fungus Education Hub

funguseducationhub.org/pediatric-mo...

Going to @idweek.bsky.social?

Join us for the MSG reception!

Register at msgerc.wildapricot.org/event-6217095

Fungus amoung us - a dive into medical mycology - with Neil Stone Podkastepisode · Pestpodden · Ekstramateriale for sesong 1 · 39 min

My specialist interest is serious fungal infection

Yes seriously..

Did you know fungi kill nearly 4 MILLION people each year?

I got to talk all about it with the "Pestpodden" podcast in Norway! 🇳🇴

podcasts.apple.com/no/podcast/p...

PEDIATRIC MOLD INFECTIONS: WHAT’S NEW? - Fungus Education Hub

funguseducationhub.org/pediatric-mo...

Tomorrow!

Get up to date on invasive candidiasis management

Register here 👇

funguseducationhub.org/closing-gaps...

New Molecular Diagnostics CME Course!

www.funguscme.org/AMT2025/inde...

Great news! @msgerc.bsky.social has just launched a new Dr Fungus App. All of the great information that is on the website is now on a (very) easy to use app put together by Matt Pullen. Apple (L) and Google (R) play store QR codes below.

Tomorrow at #TIMM2025 in Bilbao!
📍 4:15–5:45 PM
👉 @rosannesprute.bsky.social opens YECMM Clinical Research (Room 0A)
👉 @salmantongarcia.bsky.social kicks off “Diagnostic challenges in low-resource settings” (Room 0C)

Don’t miss it!

CME Registration Open: Closing Gaps in Invasive Candidiasis Care
register here 👇

t.co/jAOxUx4VKh

The new Dr. Fungus app is now available on all iOS and Android/Google devices! This app serves as a handy companion to the Dr. Fungus website, providing quick, easy access to information on fungal organisms, medical mycoses, and antifungal medications!

It's Fungal Disease Awareness Week!

Did you know that fungal infection kills many millions of people every year?

The MSG is dedicated to tackle this problem through education and research

Be aware! We are in the Fungal disease awareness week!

funguseducationhub.org/closing-gaps...

Episode 88: Mycology Unmasked: What Every Clinician Should Know - RCP Medicine Podcast In this episode of the RCP Medicine Podcast, Dr Neil Stone, consultant in infectious diseases and microbiology at University College London Hospitals and associate professor at UCL, joins host Dr Roha...

www.buzzsprout.com/1118672/epis...

CLINICAL TRIALS - HOW DO I FIND A CLINICAL TRIAL? - Mycology Advocacy, Research & Education (MyCARE)

fightfungus.org/clinical-tri...

Best Practices in Management of Fungal Pneumonias: Primary Care and Emergency Medicine Perspectives - Fungus Education Hub

funguseducationhub.org/best-practic...

funguseducationhub.org/best-practic...

New podcast from @RCPhysicians

@drneilstone.bsky.social on all things mycology!

player.rcp.ac.uk/podcasts/medic…