Michael Scherer

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...

🔗 doi.org/10.64898/202...

Proud of @juruehle.bsky.social for getting her PhD paper on biorxiv! In it, we take synthetic enhancer screens to the single cell level, offering new insight into how transcription factors and enhancers interact 👀

Early bird registration is closing Feb 28! We will have an AMAZING party!

La investigación del cáncer en 2025 | Contra el Cáncer Descubre los proyectos y avances clave en investigación contra el cáncer que cuentan con el apoyo de la Asociación Española Contra el Cáncer en 2025

Una buena noticia para empezar el año 😊 El trabajo liderado por @larsplus.bsky.social, investigador del CRG, ha sido reconocido por la Asociación Española contra el Cáncer como uno de los avances de investigación más destacados de 2025.

ONLINE FIRST ALERT!

Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

aacrjournals.org/bloodcancerd...

@aacrjournals.bsky.social

#childhoodcancer
#epigenetics
#precisiononcology

Do not miss this conference!

If you are thinking where to do your Postdoc, I can only give my highest recommendations to join Lars and his team!

GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.

Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....

genzplyr is dplyr, but bussin fr fr no cap.

🚀 Thinking about your next big career step in science?
The Int'l PhD Program at DKFZ could be a perfect fit for you.
🌍 Work in an international environment, with 500+ doctoral researchers
🔬 Do cutting-edge cancer research
Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3

This was a lot of fun! Thanks Daylon and @arunsharmaphd.bsky.social for being great hosts!

DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma - Acta Neuropathologica IDH-mutant gliomas represent a subtype of diffuse gliomas that primarily affect patients in early to mid-adolescence. These tumors are classified into three distinct CNS WHO grades of malignancy. Accu...

DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas.
doi.org/10.1007/s004...

Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.

#IRBBarcelona⁩ & ⁨@crg.eu scientists identify DNA “barcodes” that mark blood cell #aging—accelerating after 50. Published in @nature.com, the work could pave the way for preventive, personalized #antiaging therapies.

https://youtu.be/ST5YmqqMcuQ

@alejofraticelli.bsky.social 

#AgingResearch

🧪

Wie Immunzellen kommunizieren, um Krankheiten und Krebs zu bekämpfen Ein interdisziplinäres Team aus Wissenschaftlerinnen und Wissenschaftlern vom Berlin Institute of Health in der Charité (BIH), vom Max Delbrück Center, dem Deutschen Krebsforschungszentrum (DKFZ), dem...

Ein Team aus Forschenden vom BIH, @mdc-berlin.bsky.social, DKFZ, HI-STEM und @qmul.bsky.social hat eine Technologie zur Entschlüsselung der Immunzell-Kommunikation entwickelt. Damit lässt sich unter anderem ablesen, warum Immuntherapien bei manchen Menschen wirken bei anderen nicht.
t1p.de/w3v16

Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...

Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response https://www.biorxiv.org/content/10.1101/2025.07.30.667694v1

Do you want to improve our understanding of therapy resistance induced by epigenetic heterogeneity? Do you have a PhD in Molecular Biology or related fields? Join us as a (fully-funded) Postdoc in the Division of Cancer Epigenomics at DKFZ. More information here: www.dkfz.de/en/cancer-ep...

DNA demethylation-mediated downregulation of MNX1 in acute myeloid leukemia - Leukemia Leukemia - DNA demethylation-mediated downregulation of MNX1 in acute myeloid leukemia

In our study published in Leukemia, we showed that HMA treatment can also lead to repression of oncogenes such as MNX1 through the activation of miRNAs. Great work by Simge Kelekci from our division. www.nature.com/articles/s41...

Out in Leukemia (@natureportfolio.nature.com). Hypomethylating agents (HMAs) such as decitabine are used in clinical practice for the treatment of Acute Myeloid Leukemia and expected to re-activate tumor suppressor genes de-activated by aberrant DNA methylation.

The next #ScienceatDKFZ event will take place on Monday, 23 June 2025, at 4 pm. In addition to the keynote lecture by Chong Sun, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...

Clonal tracing with somatic epimutations reveals dynamics of blood ageing Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...

Stunning @nature.com paper from the labs of our great friends @larsplus.bsky.social and @alejofraticelli.bsky.social on modelling somatic epimutations for transgene-free single-cell clonal tracing in blood ageing! Enjoy the read: doi.org/10.1038/s415... 🧪

The genetic architecture of an allosteric hormone receptor Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...

1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶

Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.



www.biorxiv.org/content/10.1...



With @benlehner.bsky.social

[1/7]

"A partir de los 50 casi todas las células madre se llaman Rodríguez" (Y eso es malo) Un estudio liderado por dos centros de investigación de Barcelona ha descubierto que, a partir de esa edad, cada vez tenemos menos células madre sanguíneas y las que hay se replican cada vez con más e...

Thanks to phenomenal work by @crg.eu and @irbbarcelona.org press offices, we got to communicate our findings on 🧬 methylation barcodes and 🩸 blood ageing to a wide audience. A cool experience!

🧵 with highlights in 5 languages and funny moments 😬😅

cadenaser.com/nacional/202... (1/n)

Dès l’âge de 50 ans, les cellules de notre sang s’appauvrissent Une équipe espagnole a retracé l’évolution des lignées de cellules du sang chez 13 personnes de 35 à 70 ans. A partir de la cinquantaine, le nombre de cellules souches capables d’engendrer des cellule...

🇫🇷: @scherermich.bsky.social was brave enough to speak to @lemonde.fr in French 💪! Excellent article that definitely sticks out with the accompanying visual.
www.lemonde.fr/sciences/art... (6/n)

15,8 Millionen Euro für neuen Sonderforschungsbereich zu Blutkrebs Die Deutsche Forschungsgemeinschaft (DFG) unterstützt in den kommenden vier Jahren den neuen Sonderforschungsbereich (SFB) 1709 „Zelluläre Plastizität in malignen myeloischen Erkrankungen – Vom Mechan...

📢Die @dfg.de unterstützt in den kommenden vier Jahren den neuen Sonderforschungsbereich „Zelluläre Plastizität in malignen myeloischen Erkrankungen – Vom Mechanismus zur Therapie“ der Medizinischen Fakultät Heidelberg mit rund 15,8 Mio. Euro.
➡️ t1p.de/rpslw

The fantastic lineup for our latest webinar series, Unlocking the Epigenome: Precision Tools for Complex Diseases, includes: @chiaraherzog.bsky.social, @a-radzisheuskaya.bsky.social, @sankarinagarajan.bsky.social, @sebpreissl.bsky.social, @scherermich.bsky.social, and more! Check them out below!

Tracing human clones and lineages with DNA methylation. Congratulations for this fascinating breakthrough!

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

www.nature.com/articles/s41...

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

Clonal tracing with somatic epimutations reveals dynamics of blood ageing
www.nature.com/articles/s41...

Scientists make breakthroughs on blood ageing and limb regrowth Two new studies could help develop better therapies for rejuvenation and regeneration

Scientists make breakthroughs on blood ageing and limb regrowth

https://www.ft.com/content/a1f83886-fb29-4f5f-9577-bec61dfd31d2