Kishor Sivaraj

I’m thrilled to announce that I will be giving a talk on Single Cell RNA Sequencing of Bone Stromal Cells at the ECTS 2025 Congress in the beautiful city of Innsbruck, Austria! 🇦🇹 Join me!
www.ects2025.org
@ectssociety.bsky.social

Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...

"Great news! The ECTS Congress is heading to Innsbruck! 🏔️ Join us for an incredible gathering of ideas, collaboration, and innovation in this stunning alpine city. We can’t wait to see you there! #ECTS2025

Adrenocortical stem cells in health and disease Nature Reviews Endocrinology, Published online: 10 March 2025; doi:10.1038/s41574-025-01091-2This Review outlines the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche — comprising capsular stem cells and cortical…

ICYMI: New content online: Adrenocortical stem cells in health and disease

The 2025 Mini Symposium is only TWO weeks away. To hear talks from @ralfhadams.bsky.social , A/Prof Sanjay Patel, @ianparish.bsky.social and @cgerlachlab.bsky.social - you can register here 👉 www.iseh.org/2025MiniSymposium

🔥Excited to share our preprint doi: doi.org/10.1101/2025... on the spatiotemporal reprogramming of the bone marrow in myelofibrosis #fibrosis #MPNsmlead in a highly collaborative effort 👇- looking forward to hearing your thoughts and please share 👍

Thank you for highlighting our work 🙏

very interesting research and great mentor!!

Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩

#SmoothMuscleCell Mechanobiology

Effects of Pulsatile (not Cyclic) Stretch
(9% physiological strain, heart pressure waveform, 1 Hz, FlexCell) on
10 select genes human aortic SMC for 4/24/72 h

COL1A1
MMP2
LAMA5
FBN1
TGFBR1/2
MLCK
PRKG1
TAGLN
TNFRSF11B

#SciRep 2024
www.nature.com/articles/s41...

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)

Local erythropoiesis directs oxygen availability in bone fracture repair https://www.biorxiv.org/content/10.1101/2025.01.10.632440v1

View from lab @mpi-muenster.bsky.social

Endothelial LATS2 is a suppressor of bone marrow fibrosis - Nature Cardiovascular Research Sivaraj, Majev et al. demonstrate that the inactivation of Lats2 in endothelial cells triggers the upregulation of serum response factor and endothelial-to-mesenchymal transition, leading to myofibrob...

🦴 vessels 🔥 www.nature.com/articles/s44...