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Paolo Ciracì

@paolociraci.bsky.social

M.D. - Medical Oncology Resident at the University Hospital of Pisa (Italy), focused on clinical and translational research on gastrointestinal cancers

319 Followers  |  265 Following  |  10 Posts  |  Joined: 23.05.2025  |  1.4053

Latest posts by paolociraci.bsky.social on Bluesky

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Final results of the PARERE Study

🩸 428 mCRC pts screened via liquid biopsy for anti-EGFR re-tx
🧬 >⅓ RAS and/or BRAF mut in ctDNA
❌ No OS diff (pani→rego vs rego→pani)
✅ Higher ORR, DCR & PFS with pani, regardless of sequence

doi.org/10.1016/j.anno…

25.10.2025 08:19 — 👍 1    🔁 0    💬 0    📌 0
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Back from an outstanding #ESMO25 in Berlin!
Major milestones: PARERE concomitantly published in Annals of Oncology, final results from the TriComB study, and the 2025 @myesmo.bsky.social Research Fellowship Award

22.10.2025 08:08 — 👍 2    🔁 0    💬 0    📌 0
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Excited to begin this new journey at the Hospital del Mar Research Institute as a 2025 @myesmo.bsky.social Research Fellow!

#ESMO25 #myesmostory

21.10.2025 07:12 — 👍 3    🔁 0    💬 0    📌 0
https://www.annalsofoncology.org/article/S0923-7534(25)04934-8/fulltext

The final results of the PARERE study by GONO Foundation concomitantly published on Annals of Oncology
#ESMO25 @myesmo.bsky.social

Open Access 👉 t.co/sTomWwT8Do

18.10.2025 20:09 — 👍 1    🔁 0    💬 0    📌 0
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#ESMOGI25: Randomised #ClinicalTrials and real-world studies in #mCRC provide further evidence in favour of anti-EGFR rechallenge, particularly with a prolonged intertreatment interval.

Read more in the #ESMODailyReporter

🔗 ow.ly/ZfB450Wl2G8

04.07.2025 14:36 — 👍 5    🔁 2    💬 0    📌 0
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#ESMOGI25 was an incredible experience — truly honored to present results from the PARERE study by GONO in the Proffered Session

@myesmo.bsky.social

05.07.2025 10:52 — 👍 6    🔁 2    💬 0    📌 0
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First results from the PARERE trial by @FoundationGono

🩸RAS and BRAF ctDNA muts: >1/3 of mCRC patients eligible for anti-EGFR re-treatment
➡️ pani re-tx was associated with higher ORR, DCR, and longer PFS independently of the treatment sequencing

#ASCO25
@ascocancer.bsky.social

01.06.2025 17:50 — 👍 7    🔁 0    💬 0    📌 0
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Updated results from the phase 3 TRIPLETE study by GONO

➡️ Upfront mFOLFOXIRI plus panitumumab resulted in a longer OS of 41.1 vs 33.3 mos (FOLFOX/pan)
➡️ no significant difference in PFS and ORR was confirmed

#ASCO25 @ascocancer.bsky.social

01.06.2025 17:45 — 👍 2    🔁 0    💬 0    📌 0
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DYNAMIC-III:

🩸27% of stage III CRC are ctDNA pos

➡️ ctDNA is prognostic but not predictive for adjuvant chemo escalation

#ASCO25 @ascocancer.bsky.social

30.05.2025 21:02 — 👍 3    🔁 2    💬 0    📌 0
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Enco/cet + mFOLFOX6 is the new standard 1L for BRAF V600E mut mCRC patients
➡️ mPFS: 12.8 vs 7.1 mos
➡️ mOS: 30.3 vs 15.1 mos

#ASCO25 @ascocancer.bsky.social

30.05.2025 20:01 — 👍 6    🔁 2    💬 0    📌 0
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The most clinically relevant science in oncology will be presented at #ASCO25, and you can now view the full 5,000 abstracts & their presentation date, time & location info: brnw.ch/21wSRrH

22.05.2025 21:59 — 👍 16    🔁 10    💬 0    📌 4
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Our review and evidence-based algorithm on late-line treatment options for metastatic colorectal cancer patients @natrevclinonc.nature.com

Full Article 👉 rdcu.be/d0AHE

25.05.2025 19:36 — 👍 15    🔁 2    💬 1    📌 0

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