Alicia Che

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...

Congrats Alex! Well deserved

Congrats Julia!

A Multi-Omic Approach Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder Yale scientists, led by senior author Matthew Girgenti, PhD, assistant professor of psychiatry, established a brain multi-omic and multi-region analysis

In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍

Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD

Beautiful work Alex, Ling-Xiao and Clara! Grateful to be part of it!

Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪

Led by Ling-Xiao Shao and @ItsClaraLiao

Funded by @NIH @NIMHgov

📄 Read in @nature.com - www.nature.com/articles/s41...

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Soohyun is a friend and colleague who is kind, generous, and absolutely brilliant. Sending love. We stand together ❤️

How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

This is the most relevant article to NIH and research cuts I’ve seen.

Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”

globalnews.ca/news/9793403...

Folks trying to save USAID are trying to counterprogram Musk's $40 million Super Bowl ad. They're asking everyone to share this video as widely as you can today: www.youtube.com/watch?v=PqUE...

Indirect Costs and Trump's Attack on Independent Voices.

My latest post:

buttondown.com/sbagen/archi...

Opinion | Don’t Believe Him (Gift Article) Look closely at the first two weeks of Donald Trump’s second term and you’ll see something very different than what he wants you to see.

It’s not easy to keep a cool head with muzzle velocity. Great article. Will share with all my trainees. (Gift without paywall)

www.nytimes.com/2025/02/02/o...

Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex - Nature Communications The development of translaminar cortical circuits remains incompletely understood. Here authors show cortical layer 5 provides translaminar inputs to layer 2/3 during development, strengthening layer ...

Was hoping to share good news at a better time but realized it may not come for 4 years, so here it is! First paper from the lab. We show a transient L5 to L2/3 connection in developing cortex that drives activity-dependent maturation of upper-layer circuits.
www.nature.com/articles/s41...

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Really proud to see my postdoc work out!!

We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging

www.science.org/doi/10.1126/...

Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning - Nature Communications Artificial neural networks, central to deep learning, are powerful but energy-consuming and prone to overfitting. The authors propose a network design inspired by biological dendrites, which offe...

Dendrites doing AI problems, so great to see the increased activity! www.nature.com/articles/s41...