Tiphaine Le Roy 🦠

Reconsidering the microbial origins of primary sclerosing cholangitis and related autoimmune disorders: A case for the antro‐duodenal microbiome | Request PDF Request PDF | On Aug 5, 2025, Richard Kellermayer and others published Reconsidering the microbial origins of primary sclerosing cholangitis and related autoimmune disorders: A case for the antro‐duod...

Location in the digestive tract matters!

💩 microbiota ≠ duodenal microbiota

As our understanding of the effect of the #microbiome in #PSC grows, it beomes more nuanced.

#LetsBeatPSC
#primarysclerosingcholangitis

Some people can't even do a proper copy-paste 🤷‍♀️

😂😂 not sure it will enhance it significantly but go ahead 😂

Agora2 ? I’m not a specialist in the field but I am very interested by this subject and what you will find 😅

We are currently discussing in the lab putting all our codes on github before publication, as you can understand, it makes me nervous that the code could be retrieved by someone even in private mode before the studies are published 😅 and I would like to send the original post to my colleagues.

1/2. a few month ago, I saw someone her and/or on Linkedin telling that he discovered that his private code on github was stolen and used in a paper not acknowledging him. I can't find it, does someone remember this and send me the link to the original post ? #science

This a nice piece of work from a mechanistic point of view, but considering the detrimental effect of Peptostreptococcus anaerobius on colorectal carcinogenesis and resistance to immuno-therapies, do we know if other bacteria have a similar hability to ferment proline ?

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes - Nature Communications Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J S...

Standardized mouse model GM15
www.nature.com/articles/s41...

What if We Can't Rely on PubMed? - Absolutely Maybe PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…

Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally:

absolutelymaybe.plos.org/2025/02/14/w...

#medlibs

technically not a problem if you eat the whole cake by yourself
🦠 🎂 🤔

Diversity in women and their vaginal microbiota Women’s health is essential to global societal and economic wellbeing, yet health disparities remain prevalent. The vaginal microbiota plays a critical role in health, with research indicating that re...

📢Sarah Lebeer (@sarahlebeer.bsky.social) and colleagues at the Isala team call for a more comprehensive, global, and inclusive understanding of the #vaginal #microbiome, critically reflecting on the use of 'race' and 'ethnicity' in studies.

Read the Opinion piece here: www.cell.com/trends/micro...

And…. I didn’t get it 🙃😭. At least it was fast.

(𝘛𝘳𝘺𝘪𝘯𝘨 𝘵𝘰 𝘯𝘰𝘳𝘮𝘢𝘭𝘪𝘻𝘦 𝘳𝘦𝘫𝘦𝘤𝘵𝘪𝘰𝘯 𝘩𝘦𝘳𝘦 𝘣𝘦𝘤𝘢𝘶𝘴𝘦 𝘪𝘵 𝘪𝘴 𝘩𝘢𝘳𝘥 𝘵𝘰 𝘩𝘢𝘯𝘥𝘭𝘦.)

bsky.app/profile/titi...

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...

#weekendreading🔬

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

@cellpress.bsky.social
#microsky #microbiome #diet

www.cell.com/cell/fulltex...

bsky.app/profile/titi...

... colossal amounts of wet lab work and, at least in my experience, it is not easy to get funding for such projects.

www.nature.com/articles/s41...

Hold my beer (ℎ𝑒𝑎𝑑𝑠 𝑜𝑓𝑓 𝑡𝑜 𝑡ℎ𝑒 𝑚𝑖𝑐𝑟𝑜𝑏𝑖𝑜𝑙𝑜𝑔𝑦 𝑙𝑎𝑏). 🧫 🦠🧪
Kidding aside, I completely agree that classical microbiological approaches are crucial to address causality and mechanisms. However, it requires...

#MicroSky #microbiomesky #science

Au fait, on s'est dit qu'il fallait quand même qu'on vous propose aussi un kit avec les adresses de toute l'équipe d'Epsiloon. Parce que oui, on est tous là maintenant. Bienvenue ! go.bsky.app/3EFfgk2

Nope, our holidays are not their priority. Last summer a 5th sept deadline from the ANR screwed up my summer holidays 😭. Hope you got the grant (I didn’t 🫠)

Ho I could 100% have missed it 😬😇.

I hope so… but if they decide to give me money they can take as long as they want 😂

French diabetes association 😅

a man in a suit and tie is standing in the rain and crying . ALT: a man in a suit and tie is standing in the rain and crying .

Me realising that the deadline for a grant submission is sunday night, not monday night, and that I need to cut my holiday short now, not tomorrow.
🧫 🦠🧪#esr #MicroSky #microbiomesky #PhDSky #AcademicSky

ChatGPT 4.o QUERY: Improve this: "Ask an LLM to rephrase an awkward sentence. You can judge for yourself whether its suggestion improves your original text." RESPONSE: "Ask a language model to rephrase an awkward sentence and see if the result enhances your original wording. You can decide for yourself if its suggestion is an improvement."

Many of my students and a few of my colleagues run their writing through an LLM to improve the prose.

LLMs can make bad writing better, but they can just as easily make decent writing worse. Note the lack of flow and the added redundancy in the example below.

J'en ai PLEIN LE FIAK de voir les gens foutre de l'IA partout même s'il y en a pas besoin, puis de casser les miches aux gens un peu réfractaires en mode "Ohlala c'est juste un outil ce qui est important c'est comment on s'en sert".

Many microbiologists probably already know this, but I was today years old when I learned that 𝘛𝘶𝘳𝘪𝘤𝘪𝘣𝘢𝘤𝘵𝘦𝘳 𝘴𝘢𝘯𝘨𝘶𝘪𝘯𝘪𝘴 is filamentous 😅.

#MicroSky #microbiomesky 🧫 🦠🧪

I have to tag @arthremys.bsky.social and her profile picture featuring the « new » lab when our institution made us leave our old lab 😂😂

I know 100% that this doesn't mean my project proposal was crap, but every rejection hurts.
🦠🧫#esr #microbiome #MicroSky #microbiomesky #science

I also study host-microbe interaction in the context of metabolic diseases, could you add me please.

I am guilty of using the term "gut microbiome" many times in studies based on the fecal microbiota analyses, but yes, you are right and we should be more carreful to use the right term.

It's certainly more complicated and invasive, but it can be done, we and other have done it recently, using endoscopy or ingestible capsules. Each technique has its limitations though...