TJ McCorvie

A do-or-die moment for the scientific enterprise Reflecting on our paper “The entities enabling scientific fraud at scale are large, resilient, and growing rapidly”

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community.

reeserichardson.blog/2025/08/04/a...

A comprehensive digital map of human metabolism to improve disease treatment Thousands of genes, enzymes, and biochemical reactions involved in inherited metabolic diseases (IMDs) are now included in the most complete digital map of human metabolic pathways to date. The map al...

A wealth of newly integrated data will help accelerate diagnosis and personalized treatment of inherited metabolic diseases. SIB contributed to this first draft of the most comprehensive digital map of human metabolic pathways to date as part of Recon4IMD, a Swiss/EU/UK-funded project. See more👇

Springer Nature retracts book with fake citations. Help us find more cases like this. Springer Nature has officially retracted a book on machine learning following coverage by Retraction Watch. A reader sent us a tip about this book; we’d love your help identifying more. As we reported, the book, Mastering Machine Learning: From Basics to Advanced, contained many citations to nonexistent works. These fake references are a hallmark of … Continue reading Springer Nature retracts book with fake citations. Help us find more cases like this.

Springer Nature retracts book with fake citations. Help us find more cases like this. https://retractionwatch.com/2025/08/04/springer-nature-retracts-book-fake-citations-help-us-find-more/

Frontiers' Research Integrity team uncovers peer review manipulation network Frontiers Research Integrity Auditing team has uncovered a network of authors and editors who conducted peer review with undisclosed conflicts of interest and w

Fox finds raccoons in henhouse.

www.frontiersin.org/news/2025/07...

Associate or Senior Editor, Nature Biomedical Engineering Job Title: Associate or Senior Editor, Nature Biomedical Engineering Organization: Nature Portfolio Location: New York, Jersey City, Shanghai or Beijing – Hybrid Working Closing date: August 20, 2025 ...

If you’d like to join me on this journey, NBME is hiring!! This is a fantastically rewarding career that keeps you very much in science. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Queuosine is incorporated into precursor tRNA before splicing pubmed.ncbi.nlm.nih.gov/40745156/ #cryoEM

As measles spreads, old vaccination canards do too For as long as there have been vaccines, there has been passionate opposition to them

"Health freedom" arguments against vaccination are popular again, but they've been tested in courts for centuries, and always found lacking. In today's @FT I explain why this dubious stance, and ancient history of antivaccine disinformation

www.ft.com/content/0307...

If you are applying to a PhD, don't use an LLM in composing your proposal.

If you are doing a PhD, don't use an LLM to do the writing and reading and thinking for you.

Sorry, I am going to die on this hill.

Scientist and green-card holder detained at SFO for more than a week, lawyer says A Texas Lyme disease researcher faces deportation after being detained in San Francisco after returning from his brother's wedding in South Korea.

We are failing to meet the promise of this country's founding documents, and it hurts all of us.

Will's story is here in the LA Times:

From left to right, Dr. Albert Mulenga, William Tae Heung Kim, Dr. Thu Thuy Nguyen, Dr. Alex Kiarie Gaithuma, Dr Hassan Hakimi and Emily Bencosme Cuevas. Kim is a Texas A&M researcher who was detained in San Francisco last Monday despite being a permanent resident of the United States and a green card holder. COURTESY OF TEXAS A&M UNIVERSITY

I NEED to tell you the story of Tae Heung “William” Kim.

He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.

He's a *legal permanent resident* of the United States.

And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...

Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.

Screenshot of the wsj that says Trump Administration Scraps Effort to Pause Health-Research Funding White House officials intervened to force budget office to reconsider health-research funding pause

Wait! Good news!! The attempt to stop research funding has *already* been scuttled!

“Funding for scientific research should not be controlled by a small group of highly paid and unaccountable insiders at the NIH, many of whom stay in power for decades. The NIH monopoly on directing research should be broken”.

Project 2025, page 462. Today, Russell Vought did just that.

This is what is so frightening about this informed propaganda. Technically, yes, the IC Directors decide what is and is not funded. But in PRACTICE, they have a tiny input compared with the process of peer review. See 🧵👇🏾

Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions:
* Postdoc in structural biology (cryoEM, ideally with X-ray too)
* Full time lab manager/technician with wetlab experience

"...cancer mortality rate declined by 34% from 1991 to 2022 in the United States, averting approximately 4.5 million deaths."
- ACS Cancer Statistics, 2025.

In 30 years, we've cut the death rate from cancer by a third. The current pipeline has *actual cures* for specific cancers in it.

Widespread misidentification of scanning electron microscope instruments in the peer-reviewed materials science and engineering literature Materials science and engineering (MSE) research has, for the most part, escaped the doubts raised about the reliability of the scientific literature by recent large-scale replication studies in psych...

New study @reeserichardson.bsky.social dropped:
Widespread misidentification of scanning electron microscope instruments in the peer-reviewed materials science and engineering literature

When descriptions in the Methods do not match the photos in the Results.
journals.plos.org/plosone/arti...

I want to create a "Behind the Paper"-like perspective article for CSH Protocols, where authors would succinctly summarize a recent methods paper they've published in any journal.

This can provide a bit more context & is a way for authors to directly connect with the community.

Interested? Lmk!

This is why we at NIH do what we do 💕. #FightForMedicalScience

YouTube video by Apple TV Murderbot — Dr. Mensah's Panic Attack | Scene | Apple TV+

One of my favorite scenes for a Friday: www.youtube.com/watch?v=sxQt...

Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex Nature Structural & Molecular Biology, Published online: 25 July 2025; doi:10.1038/s41594-025-01635-0Jansen et al. determined the cryo-electron microscopy structure of human GTPase-activating protein complex GATOR2 bound to CASTOR1 in the absence of arginine, providing insight into how CASTOR1 binds to GATOR2 to disinhibit GATOR1 when arginine levels are low, promoting mechanistic target of rapamycin complex 1 inactivation.

New online: Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex

Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀
www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!

Architecture and regulation of filamentous human cystathionine beta-synthase - Nature Communications Cystathionine beta-synthase is a conserved essential enzyme of one-carbon metabolism. Here, the authors show that the enzyme oligomerises to form filaments that undergo conformational and morphologica...

The EMPIAR datasets related to my work on human cystathionine beta-synthase are now released. Hopefully they are useful unusual filament cases for #cryoEM data processing
www.nature.com/articles/s41...
1. www.ebi.ac.uk/empiar/EMPIA...
2. www.ebi.ac.uk/empiar/EMPIA...
3. www.ebi.ac.uk/empiar/EMPIA...

"My main message to young scientists is simple: don’t be afraid to speak up. Research misconduct may not always be visible at first glance, but if you are vigilant and critical, you can spot it."

Cheers @lonnibesancon.bsky.social !

The COVID-19 pandemic transformed this scientist into a research-integrity sleuth Lonni Besançon has faced online abuse, threats and legal challenges. But he remains proud of his service to science and society.

Lonni Besançon faced online abuse, threats and legal challenges in response to his research integrity sleuthing during the COVID-19 pandemic

go.nature.com/4m5DN0X

It's a good discussion! I agree with a lot of what is being said. The table showing metrics for cryo-EM processing and model stats does need updating. Average and ligand Q-scores definitely should be stated