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Brian English

@sciencethecat.bsky.social

senior scientist at Janelia | single particle tracking & #microscopy πŸ”¬ | PhD on single-molecule enzymatic dynamics | my path: πŸ‡©πŸ‡ͺβ†’πŸ‡ΊπŸ‡Έβ†’πŸ‡ΈπŸ‡ͺβ†’πŸ‡ΊπŸ‡Έ | https://scholar.google.com/citations?user=UzGfR3MAAAAJ&hl=en

2,270 Followers  |  2,431 Following  |  26 Posts  |  Joined: 17.01.2024  |  1.694

Latest posts by sciencethecat.bsky.social on Bluesky

Very excited to be co-organizing this meeting. Hope to see you there!

17.10.2025 11:39 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Maud Menten was born in Canada in 1879 and completed her UG and MD education at University of Toronto. As a research assistant with Leonor Michaelis in 1912, they wrote the classic paper describing the β€œMichaelis-Menten” model of enzyme kinetics.. #WomenInScience

16.10.2025 01:02 β€” πŸ‘ 332    πŸ” 84    πŸ’¬ 5    πŸ“Œ 9

Just heard him speak at Janelia just now. Wonderful talk!

08.10.2025 16:41 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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#miasanfamilyβ™₯️

04.10.2025 20:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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(Part 1) Hear from @hhmi_news Investigator David Stern about his research program and what he's uncovering in the lab.

Stern will join the Institute in February 2026, bringing his lab and HHMI appointment to Kansas City. @hhmi.org

Read more: bit.ly/4np96Fb

30.09.2025 17:10 β€” πŸ‘ 14    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

"Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." - Jennifer Doudna (2/2)

02.10.2025 13:48 β€” πŸ‘ 21    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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The culmination of many years work. One of the most advanced light-sheet microscopes in the world!

-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!

For details see previous posts and here: github.com/amsikking/HT...

28.09.2025 18:32 β€” πŸ‘ 28    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

Congratulations Jie! @jiexiaolab.bsky.social

24.09.2025 20:22 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Stunningly beautiful RNA movies, congratulations!

22.09.2025 18:48 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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πŸš€ Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

πŸ”— www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

22.09.2025 18:27 β€” πŸ‘ 222    πŸ” 97    πŸ’¬ 6    πŸ“Œ 9
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Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubellaβ€”these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE

18.09.2025 16:34 β€” πŸ‘ 260    πŸ” 96    πŸ’¬ 4    πŸ“Œ 5
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Today’s work, aside from meetings.

12.09.2025 23:34 β€” πŸ‘ 9    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
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Head of Scientific Instrumentation Workshops EMBL is a world leader in scientific research and at the forefront in the development of cutting-edge technologies. It operates across six sites in Heidelberg (headquarters), Barcelona, Cambridge, Gre...

@embl.org Heidelberg is looking for a new Head of Scientific Instrumentation! This is an exciting opportunity at the interface between scientific research and technology development, overseeing our mechanical and electronic workshops!
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

12.09.2025 18:48 β€” πŸ‘ 35    πŸ” 32    πŸ’¬ 2    πŸ“Œ 0

Beautiful work led by @oliveringe.bsky.social. It was great fun to be involved with this project.

See Ollie’s paper and thread πŸ‘‡

09.09.2025 20:17 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thanks Misha for the shout-out!
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.

08.09.2025 16:30 β€” πŸ‘ 46    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1
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We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

04.09.2025 08:21 β€” πŸ‘ 341    πŸ” 118    πŸ’¬ 16    πŸ“Œ 8

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

01.09.2025 19:32 β€” πŸ‘ 4003    πŸ” 1352    πŸ’¬ 16    πŸ“Œ 22
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Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...

This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime

31.08.2025 20:41 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Vaccines save lives, pass it on.

30.08.2025 00:41 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 2
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(1/n) A simple, ultrastable, and cost-effective oxygen-scavenging system for long-term DNA-PAINT imaging

Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
πŸ‘‡πŸ§΅

#SuperResolution #DNAPAINT #SMLM #Microscopy

21.07.2025 15:46 β€” πŸ‘ 31    πŸ” 9    πŸ’¬ 3    πŸ“Œ 0
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A new 25-camera multifocus microscope can capture 3D volumes of living organisms at high speeds.

Using the microscope, the researchers were able to view a fruit-fly larva’s heart beating at about 2 Hz.

Read the OPN story: bit.ly/4muEQbx

#imaging #microscopy πŸ’‘βš›οΈπŸ§ͺ

22.08.2025 15:40 β€” πŸ‘ 22    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
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One of the people I'm indebted the most for creating stunningly beautiful #mesoSPIM samples was Martina Schaettin - who tragically passed away in March this year. To honor her memory, Elkhan Yusifov created an award - submit your best #microscopy images & videos! www.linkedin.com/company/mart...

22.08.2025 17:32 β€” πŸ‘ 60    πŸ” 15    πŸ’¬ 2    πŸ“Œ 2
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Clever mug :-)

26.08.2025 14:21 β€” πŸ‘ 120    πŸ” 11    πŸ’¬ 4    πŸ“Œ 4
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Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
www.nature.com/articles/nme...

22.08.2025 13:17 β€” πŸ‘ 149    πŸ” 41    πŸ’¬ 0    πŸ“Œ 0
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Wim Wenders war bei Alles gesagt? Der bedeutendste deutsche Filmregisseur unserer Zeit wird heute, am 14. August 2025, 80 Jahre alt.

14.08.2025 08:31 β€” πŸ‘ 25    πŸ” 3    πŸ’¬ 5    πŸ“Œ 0
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We’re excited to welcome @kevin-dean.bsky.social to the #mesoSPIM2025 Symposium! Explore his innovations in Multiscale Cleared-Tissue Axially Swept Light-Sheet Microscopy for imaging from organ to subcellular levels.
πŸ—ΊοΈOct 13–15 | Zurich & hybrid
Interested? Register now: t.uzh.ch/1Ss

12.08.2025 09:50 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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a bunch of balloons are flying in the sky . ALT: a bunch of balloons are flying in the sky .

I have some BIG NEWS to share today!

Today I begin my next adventure as

Chief Editor of Nature Biomedical Engineering!!

(a thread) @natmethods.nature.com @natbiomedeng.nature.com @natureportfolio.nature.com

01.08.2025 14:27 β€” πŸ‘ 695    πŸ” 34    πŸ’¬ 94    πŸ“Œ 3

I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.

18.07.2025 03:30 β€” πŸ‘ 560    πŸ” 187    πŸ’¬ 18    πŸ“Œ 11
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a yellow sign that says we 're hiring ALT: a yellow sign that says we 're hiring

Nature Methods is hiring!
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

09.07.2025 17:58 β€” πŸ‘ 31    πŸ” 32    πŸ’¬ 1    πŸ“Œ 3
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Fantastic talk by @hhmijanelia.bsky.social alumna and @embl.org group leader Dr. Claire Deo (@clairedeo.bsky.social). Stay tuned for her HHMI YouTube recording youtube.com/playlist?lis... #openscience @prevedel-lab.bsky.social @markkitti.bsky.social @kaydanych.bsky.social @rhodamine110.bsky.social

08.07.2025 18:03 β€” πŸ‘ 13    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

@sciencethecat is following 20 prominent accounts