liti_nice

Le Dr Isheng Jason TSAI et le Pr. Gianni LITI avec leurs médailles au côté du Pr. Alain FISCHER, président sortant de l'Académie des sciences.

Le Grand Prix scientifique franco-taïwanais 2025 du Conseil National des Sciences de #Taïwan et de @academiesciences.bsky.social a été décerné à Gianni LITI, de l'Institut de recherche sur le cancer et le vieillissement de Nice, et Isheng TSAI, du Biodiversity Research Center de l'Academia Sinica.

So excited to see my PhD work finally being published!!!

It was such a pleasure working with a great team!!!

Congratulations to EMBO Member Tony Hyman on his appointment as the next Director General of EMBL! We look forward to working with him to strengthen European and global #LifeSciences.

Read more:
https://www.embo.org/features/embo-congratulates-new-director-general-of-embl/

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae Yeast plasmids expressing human Aβ-42, α-syn, htt, and TDP-43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transpor...

In this #Yeast review article, Jose Ribamar Ferreira-Junior, Vittoria de Lima Camandona & Mario H. Barros show how Saccharomyces cerevisiae can be used as a model to study the cellular processes underlying #neurodegenerative disorders and to test new drugs 💊

onlinelibrary.wiley.com/doi/10.1002/...

18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′‐End Modification During TOR Inhibition. Saccharomyces cerevisiae produces exonuclease-resistant rRNA molecules upon TOR inhibition. This phenomenon occurs when cells enter the diauxic phase, upon addition of rapamycin to the culture, or wh...

In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.

onlinelibrary.wiley.com/doi/10.1002/...

Happy 40th birthday Yeast: Yeast: Vol 42, No 11 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃

You can browse it at this link:

onlinelibrary.wiley.com/toc/10970061...

Polyphosphate Accumulation Is Determined by Zinc and Inositol in Saccharomyces cerevisiae Zinc and inositol supplementation during phosphate starvation significantly enhances final polyphosphate levels in S. cerevisiae.

In the latest #Yeast research article, Alexander Deitert, Lars M. Blank and team investigated the effect of zinc and inositol in polyphosphate accumulation in Saccharomyces cerevisiae, revealing their role in energy metabolism and phosphate signalling.

onlinelibrary.wiley.com/doi/10.1002/...

Characterization of Vector Elements and Soluble Expression of Pcv3 Cap Protein in Kluyveromyces Marxianus We engineered a vector system that was suitable for Kluyveromyces marxianus-based recombinant protein expression. Endogenous promoter PDC1 with high expression strength was used in this vector system...

In this new #Yeast research article Yueting Zheng, Wei Yang, Wei Zhang & teams developed a new expression vector system to produce exogenous proteins in Kluyveromyces marxianus, and they successfully expressed the cap gene of porcine circovirus type 3 (PCV3).

onlinelibrary.wiley.com/doi/10.1002/...

NEW GENOME ALERT 👇: in this new #Yeast research article
@dmattanovich.bsky.social , Brigitte Gasser, Alexandra B. Graf and team published the complete and annotated genome sequence of the Komagataella phaffii type strain, revealing new genes and SNPs.

onlinelibrary.wiley.com/doi/10.1002/...

Ever wondered what is in your Tarhana dough? In the latest #Yeast research article, Burcu Ozel, Bilal Agirman, Omer Simsek and Huseyin Erten investigated the effects of backslopping on the yeast and volatile aroma compound diversity of tarhana.

onlinelibrary.wiley.com/doi/10.1002/...

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?

Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...

Happy 40th birthday Yeast: Yeast: Vol 42, No 8-10 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The new issue of #Yeast is out ... with a surprise 😄! This issue marks the 40th anniversary of the creation of our journal, in 1985. To celebrate this achievement, we made a brand new cover with the most beautiful #Yeast front pages 😍

Happy birthday Yeast!!!

onlinelibrary.wiley.com/toc/10970061...

Big congratulations to Dilanaz Arisan (@rquatrini.bsky.social 's lab) and Pablo Quintrel (@fcocubillosr.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the @smbe-chile2025.bsky.social conference in Puerto Varas 🎉🎉🎉

Sucrose‐Induced Transcriptomic Response in Ogataea polymorpha TBRC 4839 Reveals its Potential for Recombinant Protein Production Sucrose induction in Ogataea polymorpha triggers a metabolic shift, enhancing carbohydrate metabolism while suppressing amino acid biosynthesis, stress signaling, and cell division. This adaptation o....

In the latest #Yeast research article, Somsak Likhitrattanapisal, Niran Roongsawang and team investigated the genome of Ogataea polymorpha and its transcriptomic response during growth in sucrose-supplemented medium.

onlinelibrary.wiley.com/doi/10.1002/...

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth. https://www.biorxiv.org/cgi/content/short/2025.09.26.678705v1 Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab and continued for four more years as I built my own lab in Shenzhen.

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...

CRISPR/Cas9‐Mediated Construction of a YPS Gene‐Deficient Komagataella phaffii Strain for Enhanced Expression of BIAP Ⅱ CRISPR/Cas9-mediated genetic modification of a 4-copy Komagataella phaffii strain significantly reduced proteolytic degradation of the target protein BIAP Ⅱ, increasing its final purification yield t...

In the latest #Yeast research article, Haili Yu, Fuqiang Ma & team develop a new strain of Komagataella phaffii with increased production of bovine intestinal alkaline phosphatase, thanks to the editing of multiple YPS proteases with CRISPR/Cas9 technology.

onlinelibrary.wiley.com/doi/10.1002/...

New paper!
We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments.
Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work!
#metaHiC

Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...

New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...

Big congratulations to Ziv Ben-Moshe, Daishi Shirasaya and Yueming Dong for winning the best posters awards sponsored by the #Yeast journal at the #ISSY38 conference in Warsaw 🎉🎉🎉

#Yeast sponsored prizes in all major yeast conferences in 2025 and will also sponsor prizes at ISSY39 (www.issy39.org)

The special issue will be guest-edited by @pjboynton.bsky.social (Wheaton College
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).

You can find more information on the accepted topics and submission instructions by using the QR code below:

Yeast Call for Papers: International Yeasts Meetings of 2025 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

We are very happy to announce that #Yeast is launching a new special issue on the International Yeast Meetings of 2025: #ICYGMB32, #pombe2025 and #ISSY38. The deadline for abstract submission is 30th September 2025. Hurry up!!!
More info in the thread below.

onlinelibrary.wiley.com/page/journal...

Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica The discovery, description, and taxogenomic analysis of a novel species of Lachancea revealed correlations between gene content and carbon and nitrogen physiological assays.

New #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹

onlinelibrary.wiley.com/doi/10.1002/...

#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz

Predicting natural variation in the yeast phenotypic landscape with machine learning | Molecular Systems Biology imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantitative phenotypic predictions at scale. Large-...

Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social

@litinice.bsky.social will present “Continental-scale variation of Saccharomyces yeasts” at #ISSY38 in Warsaw 🇵🇱 on Sept 4, 09:00. Don’t miss it.

Exploiting the Geranylgeranyl‐Pyrophosphate‐Sensing N‐Terminal Domain of HMG‐CoA Reductase 2 to Regulate Farnesyl Pyrophosphate Synthase (Erg20p) for Improved Monoterpene Production in Saccharomyces cerevisiae Dynamic downregulation of the endogenous farnesyl pyrophosphate (FPP) synthase (Erg20p) is crucial to engineer heterologous monoterpene production in the yeast Saccharomyces cerevisiae. FPP downstrea...

Improved limonene and geraniol production in Saccharomyces cerevisiae via the modification of the farnesyl pyrophosphate synthetase Erg20p. Read more about it in the latest #Yeast research article by Zeyu Lu, @claudiavickers.bsky.social , Bingyin Peng & team.

onlinelibrary.wiley.com/doi/10.1002/...

Big congratulations to @henrigal.bsky.social (Gregory Batt's lab), Stefano Nenciarini (Duccio Cavalieri's lab) and @rmcgettigan.bsky.social (@mnemon.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the ICYGMB32 conference in Paris 🎉🎉🎉

#Yeast2025

The #Yeast2025 meeting has finally reached its end after four days of exciting talks, posters and networking activities.
Stay tuned for the upcoming special issue about the conference!
More infos will follow in the next coming weeks. 🙂

Ruairi McGettigan won the best poster prize at #yeast2025

And now is the end of #yeast2025. Fantastic meeting, superb talks/posters and lots of ideas to bring back to the lab. A lovely community to be part of. In addition, super proud that Ruairi McGettigan, PhD student in the lab, won the best poster award!!! #IGMM #Biolum #proudPI

"Meet the editors" session yesterday at #Yeast2025 in Paris where editors talked about best practices in scientific publishing. Our #Yeast journal was represented by its editor-in-chief @litinice.bsky.social