liti_nice

Sucrose‐Induced Transcriptomic Response in Ogataea polymorpha TBRC 4839 Reveals its Potential for Recombinant Protein Production Sucrose induction in Ogataea polymorpha triggers a metabolic shift, enhancing carbohydrate metabolism while suppressing amino acid biosynthesis, stress signaling, and cell division. This adaptation o....

In the latest #Yeast research article, Somsak Likhitrattanapisal, Niran Roongsawang and team investigated the genome of Ogataea polymorpha and its transcriptomic response during growth in sucrose-supplemented medium.

onlinelibrary.wiley.com/doi/10.1002/...

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth. https://www.biorxiv.org/cgi/content/short/2025.09.26.678705v1 Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab and continued for four more years as I built my own lab in Shenzhen.

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...

CRISPR/Cas9‐Mediated Construction of a YPS Gene‐Deficient Komagataella phaffii Strain for Enhanced Expression of BIAP Ⅱ CRISPR/Cas9-mediated genetic modification of a 4-copy Komagataella phaffii strain significantly reduced proteolytic degradation of the target protein BIAP Ⅱ, increasing its final purification yield t...

In the latest #Yeast research article, Haili Yu, Fuqiang Ma & team develop a new strain of Komagataella phaffii with increased production of bovine intestinal alkaline phosphatase, thanks to the editing of multiple YPS proteases with CRISPR/Cas9 technology.

onlinelibrary.wiley.com/doi/10.1002/...

New paper!
We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments.
Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work!
#metaHiC

Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...

New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...

Big congratulations to Ziv Ben-Moshe, Daishi Shirasaya and Yueming Dong for winning the best posters awards sponsored by the #Yeast journal at the #ISSY38 conference in Warsaw 🎉🎉🎉

#Yeast sponsored prizes in all major yeast conferences in 2025 and will also sponsor prizes at ISSY39 (www.issy39.org)

The special issue will be guest-edited by @pjboynton.bsky.social (Wheaton College
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).

You can find more information on the accepted topics and submission instructions by using the QR code below:

Yeast Call for Papers: International Yeasts Meetings of 2025 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

We are very happy to announce that #Yeast is launching a new special issue on the International Yeast Meetings of 2025: #ICYGMB32, #pombe2025 and #ISSY38. The deadline for abstract submission is 30th September 2025. Hurry up!!!
More info in the thread below.

onlinelibrary.wiley.com/page/journal...

Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica The discovery, description, and taxogenomic analysis of a novel species of Lachancea revealed correlations between gene content and carbon and nitrogen physiological assays.

New #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹

onlinelibrary.wiley.com/doi/10.1002/...

#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz

Predicting natural variation in the yeast phenotypic landscape with machine learning | Molecular Systems Biology imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantitative phenotypic predictions at scale. Large-...

Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social

@litinice.bsky.social will present “Continental-scale variation of Saccharomyces yeasts” at #ISSY38 in Warsaw 🇵🇱 on Sept 4, 09:00. Don’t miss it.

Exploiting the Geranylgeranyl‐Pyrophosphate‐Sensing N‐Terminal Domain of HMG‐CoA Reductase 2 to Regulate Farnesyl Pyrophosphate Synthase (Erg20p) for Improved Monoterpene Production in Saccharomyces cerevisiae Dynamic downregulation of the endogenous farnesyl pyrophosphate (FPP) synthase (Erg20p) is crucial to engineer heterologous monoterpene production in the yeast Saccharomyces cerevisiae. FPP downstrea...

Improved limonene and geraniol production in Saccharomyces cerevisiae via the modification of the farnesyl pyrophosphate synthetase Erg20p. Read more about it in the latest #Yeast research article by Zeyu Lu, @claudiavickers.bsky.social , Bingyin Peng & team.

onlinelibrary.wiley.com/doi/10.1002/...

Big congratulations to @henrigal.bsky.social (Gregory Batt's lab), Stefano Nenciarini (Duccio Cavalieri's lab) and @rmcgettigan.bsky.social (@mnemon.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the ICYGMB32 conference in Paris 🎉🎉🎉

#Yeast2025

The #Yeast2025 meeting has finally reached its end after four days of exciting talks, posters and networking activities.
Stay tuned for the upcoming special issue about the conference!
More infos will follow in the next coming weeks. 🙂

Ruairi McGettigan won the best poster prize at #yeast2025

And now is the end of #yeast2025. Fantastic meeting, superb talks/posters and lots of ideas to bring back to the lab. A lovely community to be part of. In addition, super proud that Ruairi McGettigan, PhD student in the lab, won the best poster award!!! #IGMM #Biolum #proudPI

"Meet the editors" session yesterday at #Yeast2025 in Paris where editors talked about best practices in scientific publishing. Our #Yeast journal was represented by its editor-in-chief @litinice.bsky.social

Great @embo.org keynote lecture from @balazs-papp-lab.bsky.social at the Yeast 2025 in Paris

Don’t miss @litinice.bsky.social presenting “Continental-scale 🌍 variation of Saccharomyces yeasts” 🌳 on Thursday, 24 July at 12:45 PM at #ICYGMB32 in Paris 🇫🇷! @ircan.bsky.social
@cnrsbiologie.bsky.social

The Saccharomyces Genome Resequencing Project 5 (#SGRP5) will be presented by @litinice.bsky.social at #ICYGMB32 in Paris 🇫🇷, while I'll be at #ESEB2025 in Barcelona 🇪🇸.
If you're around, come say hi - always happy to chat about genomics!

Yeast: Vol 42, No 5-7 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The third issue of #Yeast of 2025 (Volume 42, Issue 5-7, June 2025) is now out!!! It includes #technoYeast papers about new transformation methods, growth and fermentations, and even a new predacious #FantasticYeasts species 😃

You can browse it at this link:

onlinelibrary.wiley.com/toc/10970061...

Yeast Call for Papers: Yeast in Microbiomes Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The deadline for submissions to the special issue "Yeast in Microbiomes" has been extended to 15 October. We accept manuscripts exploring yeast diversity, interactions, and adaptations in diverse host environments. Hurry up and don't miss this opportunity!!!

onlinelibrary.wiley.com/page/journal...

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

Cooperative Function of Atg8‐ and TORC1‐Mediated Activities in Yeast The atg8Δ mutant is sensitive to rapamycin, and both lipidation-dependent and -independent functions of Atg8 are necessary for survival during impaired TORC1 activity. Atg8- and TORC1-mediated functi...

In this new #Yeast research article, Yumiko Oba, Miyuki Higuchi, Naoka Takahashi, Haruko Katsuta, Naoki Koike, Takashi Ushimaru & Yoko Kimura investigated the cooperative role of ATG8 and TORC1 in Saccharomyces cerevisiae.

onlinelibrary.wiley.com/doi/10.1002/...

An Investigation of TDA1 Deficiency in Saccharomyces cerevisiae During Diauxic Growth Tda1p is a protein kinase in Saccharomyces cerevisiae with unknown/disputed function. Its role during the diauxic shift was investigated in three independent transcriptomics experiment. From the evid...

In the latest #Yeast research article, Erik Y. Bjurström, Praphapan Lasin, Daniel Brunnsåker, Ievgeniia A. Tiukova & Ross D. King investigate the effects of TDA1 deficiency on gene expression during the fermentation and the respiratory phases of growth.

onlinelibrary.wiley.com/doi/10.1002/...

Nikola Tesla était un ingénieur de génie né de parents serbes orthodoxes, à Smiljan, en 1856. Rendons lui justice en rappelant que ce n'est pas une marque de voitures !
👉 https://l.sciencesetavenir.fr/CIu

Grande Marco! Congratulazioni a te e Mariana 👏👏👏

Excited to share the first paper of my PhD with @marcofumasoni.bsky.social ‬, now published in @molsystbiol.org 🥳! We explored how nutrient levels influence adaptation to perturbed DNA replication. Here’s what we learned 🧵👇 www.embopress.org/doi/full/10....

Yeast 2025 - PremC

🎉 The final Yeast 2025 conference program is now live!
Check out the full list of oral presentations and posters.
We can't wait to share the science (and more 🍷) with you!
🔗 premc.org/yeast2025/
🔗 yeast2025.exordo.com/programme/at...
#Yeast2025