Miguel Reyes-Múgica, MD

Why is your separase such a big protease? Recent structural work explains a fundamental event during cell division, the timely and specific cleavage of the chromosomal cohesin complex by the protease separase.

Great advance in science! Why is your separase such a big protease? | Science Advances www.science.org/doi/10.1126/...

For children and teens, heart and blood vessel complications of Covid overshadow the very rare and short-term risk of vaccinations, a new report from nearly 14 million kids
www.thelancet.com/journals/lan...

Chimpanzees rationally revise their beliefs The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...

Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...

Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults | Annals of Internal Medicine Background: Although physical activity recommendations increasingly consider daily step counts, it remains unclear whether step accumulation patterns—short versus sustained longer bouts—affect associa...

Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity
@annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...

Amazing video and description of Ectopia Cordis in the
@NEJM
! I have seen and written about this rare congenital heart and thoracic malformation. nejm.org/doi/full/10.... Pediatric Pathology> 1 I :85-95, 1991 & American Journal of Medical Genetics 44540 (1992)
#PediPath

Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically complex set of rare diseases of undefined pathogenesis, including mycosis fungoides (MF), lymphomatoid papulosis (Ly...

Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...

People with some cancers live longer after a COVID vaccine mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.

A vaccine that helps to fight cancer might already exist: People being treated for deadly cancers lived longer if they had received an mRNA COVID-19 vaccine.

The vaccines have this apparent life-extending effect not because they protect against COVID-19 but because they rev up the immune system.

In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...

Peter Sellers was great!

I have not used Spotify for years, since they contributed to misinformation. Bad platform.

Spotify is running ICE ads. I went to cancel on mobile and saw that this isn’t allowed on mobile. They make you cancel on desktop. You think that’s gonna stop me, Spotify? I will erase you and forget you ever existed.

THOU SHALT CANCEL SPOTIFY!!!

An illustration of a naked man. He is being hit or pierced with various weapons including knives, swords, and clubs. Next to the wounds is text describing accompany treatments. This illustration is from the Wellcome Collection in London.

“Wound Man” is an illustration which first appeared in European surgical texts during the Middle Ages. It laid out schematically the various wounds a person might suffer in battle or in accidents, with accompanying text stating treatments.

It's Friday! Tag yourself as a wound 🫠

It is amazing to see the multitude of possibilities! The illustration may have represented an advanced medical compendium of traumatic medicine. We have made a few advances since then! #HistoryofMedicine is fascinating!

Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...

A new world record for ultra rapid whole genome sequencing and interpretation for critically ill individuals less than 4hrs! www.nejm.org/doi/full/10....

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling - Scientific Reports Scientific Reports - Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling

Highly relevant paper for #PediPath: www.nature.com/articles/s41...

Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically complex set of rare diseases of undefined pathogenesis, including mycosis fungoides (MF), lymphomatoid papulosis (Ly...

Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...

This 4-year-old's heart is failing. A federal grant that might help him was canceled A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.

A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down. n.pr/3KIfcSn

Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically complex set of rare diseases of undefined pathogenesis, including mycosis fungoides (MF), lymphomatoid papulosis (Ly...

#PediPath Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...

Nobel Laureate Professor Sir John Gurdon dies aged 92 It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

Some arrive, others depart. John Gurdon, Nobel Laureate 2012, has passed.

www.cam.ac.uk/research/new...

"Anyone who is interested in the current and future states of healthspan treatments can appreciate......"—Prof @ctmurphy1.bsky.social @nature.com
www.nature.com/articles/d41...

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

September 29, 1964: the first Mafalda comic strip appears in Primera Plana magazine. The rest is history.

I hope you recover fully soon!

This seems like a good time to repost this thread…. 💉

Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.

The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...

In places like Baltimore, for example, the gap between inner-city and suburban residents can add up to a staggering 20 years.

Read more ⬇️

Transformative Research in Cystic Fibrosis | NEJM Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

Interesting article, relevant to #PediPath! Transformative Research in Cystic Fibrosis | New England Journal of Medicine www.nejm.org/doi/full/10....