Langridge Lab

A digital illustration of DNA with the text "Funded PhD, Out of order: investigating genetic and environmental drivers of genome rearrangement, with Dr Gemma Langridge, Apply by 2 December 2025"

🎓 #PhDPosition !

🧬 Out of order: investigating genetic and environmental drivers of genome rearrangement with Dr Gemma Langridge @langridgelab.bsky.social

📅Apply by 2 December

➡️ buff.ly/n7AAs8b

Lovely reminder from @langridgelab.bsky.social that today’s actually the first day of the final year of my PhD – only a slightly daunting prospect…

We are so pleased to share that our @stevenrudder.bsky.social passed his viva with flying colours today 🥳 👏🎉 Congratulations Dr Rudder!! Huge thank you to Adrain Egli & @alisonmather.bsky.social for examining #PhDone #AcademicChatter You have definitely left your mark on the group & will be missed🦆

Delighted to share that @stevenrudder.bsky.social has passed his viva today!! Congratulations Dr Rudder, and a huge thank you to @alisonmather.bsky.social and Prof Adrian Egli for examining. Steven, this is so well deserved, we're all super proud of you #PhDone

Delighted to celebrate with @stevenrudder.bsky.social, who has passed his viva today!! Cannot believe your time with the @langridgelab.bsky.social is already over but this is a long time coming & you deserve this so much! Go forth & do your 💩 but please stay in touch #PhDone #academicsky #PhD

Well that's a wrap @biochemsoc.bsky.social #BioPhyChrom2025 thank you to the organisers & everyone here for contributing to a wonderful week. Looking forward to hopefully seeing you all again in Paris 🇫🇷

@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@vslioy.bsky.social

We couldn't really let this #postdocappreciationweek pass without pointing out that we've doubled our awesome postdoc quota this year 💪💪 Between Claire and @emmabeansworth.bsky.social this group runs like a well oiled machine and we can't thank you enough for it 🤩 #NPAW2025

It's #postdocappreciationweek! this year for the 1st time I have a special shout out to the @langridgelab.bsky.social's other VIP (Very Important Postdoc). Claire Hill you are immense addition with your CHill nature. Thank you for taking a good share of the load in looking after the group🐧 #NPAW2025

We have been hearing great things about @biochemsoc.bsky.social #BioPhyChrom2025 & it looks like our Emma is having fun.. maybe too much?😉

Don't worry when she's back she will be writing a paper on this work showing that genomic rearrangement can impact #virulence & #AMR. Find Poster 9 to hear more

What a great 1st session @biochemsoc.bsky.social #BioPhyChrom2025. A great mix of talks & discussion points from all speakers

I am looking forward to sharing my work showing that genome structure variation can influence #virulence & #AMR. Come see me at poster 009

We are looking forward to @vslioy.bsky.social visiting @quadraminstitute.bsky.social tomorrow and hearing about her work on aquired genes shape #Salmonella's chromatin.

We are also looking forward to Vicky taking @emmabeansworth.bsky.social to #BioPhyChrom2025... Peace & quite for a whole week!🤫

UK mode ON 🇬🇧 #BioPhyChrom2025 ahead! First stop @quadraminstitute.bsky.social for some Salmonella chromatin chats with @emmabeansworth.bsky.social & @langridgelab.bsky.social

Genomic epidemiology of SARS-CoV-2 in Norfolk, UK, March 2020–December 2022 In the UK, the COVID-19 Genomics UK Consortium (COG-UK) established a real-time national genomic surveillance system during the COVID-19 pandemic, producing centralized data for monitoring severe acut...

Eleanor's paper explores the #genomic #epidemiology of #COVID in Norfolk, UK during the #pandemic, showing the powers of #sequence surveillance

Also just happens to be featuring as 1 of the most read articles in @microbiologysociety.org's #MicrobialGenomics this month!

What a team! What a year!

Genomic diversity of non-typhoidal Salmonella found in patients suffering from gastroenteritis in Norfolk, UK Salmonella is a significant public health pathogen responsible for a wide spectrum of diseases, ranging from gastroenteritis to invasive non-typhoidal salmonellosis and enteric fever. Although advance...

Both papers are in @microbiologysociety.org's #MicrobialGenomics...

Steven's reveals within-host genome diversity of #Salmonella whilst highlighting the limits of single-colony #sequencing, showing diversity which impacts #AMR & transmission💊

He also submitted his thesis last week #PhDachievements

As we leave late summer behind & enter autumn & some normality, we have been able to get together to celebrate some awesome achievements by our @stevenrudder.bsky.social & @eh-hayles.bsky.social. In a Langridge lab tradition, both received their coasters of their 1st author papers in the group!🎉🥳🎊

Genome-scale metabolic modelling of trimethoprim’s mode of action reveals free ATP salvaged to restore purine pool Trimethoprim is a clinically important antibiotic for treating urinary tract infections yet its mechanism of killing remains elusive due to a cascade of effected metabolic reactions. Metabolites avail...

Once you have read that gem why not treat yourself to another from Cailean's PhD with @gemma-langridge.bsky.social

This preprint uses genome-scale #metabolicmodelling to see how #trimethoprim effects 𝘌. 𝘤𝘰𝘭𝘪's metabolism & how these can be selectively counteracted with growth media supplementation

Genomic diversity of non-typhoidal Salmonella found in patients suffering from gastroenteritis in Norfolk, UK Salmonella is a significant public health pathogen responsible for a wide spectrum of diseases, ranging from gastroenteritis to invasive non-typhoidal salmonellosis and enteric fever. Although advance...

Looking for your next summer read?

Our @stevenrudder.bsky.social's 1st 1st author paper is now published in @microbiologysociety.org's #MicrobialGenomics

Revealing within-host genome diversity of #Salmonella & highlighting the limits of single-colony #sequencing with impacts on #AMR & transmission

Big news! @quadraminstitute.bsky.social Microbe of the Month is Salmonella Typhi! A tiny troublemaker with a big history🦠 Check out Typhi's reel to learn about its genetic gymnastics and long-term love for Mary Mallon 💝 #MicrobeoftheMonth #SalmonellaSlay See @quadraminstitute on instagram for more!

How SARS-CoV-2 impacted Norfolk: What a three year study taught us - Quadram Institute “In the five years since COVID-19 was declared a pandemic, we’ve learnt a lot – not just about the virus that causes COVID-19 (SARS-CoV-2) but also how to track the spread and evolution of microbes th...

We heard a lot about how #COVID impacted the nation, but what happened locally?

Here @eh-hayles.bsky.social discusses her research exploring & understanding how #SARS-CoV-2 spread & evolved in #Norfolk during the #COVID-19 pandemic 🦠 & shows how we can use the past to be prepared for the future💪

How SARS-CoV-2 impacted Norfolk: What a three year study taught us - Quadram Institute “In the five years since COVID-19 was declared a pandemic, we’ve learnt a lot – not just about the virus that causes COVID-19 (SARS-CoV-2) but also how to track the spread and evolution of microbes th...

Waiting for the rain to stop? ⛈️ Need a good read? 📃

Our @eh-hayles.bsky.social has written a blog discussing her research exploring & understanding how SARS-CoV-2 spread & evolved in #Norfolk during the #COVID-19 pandemic 🦠

She shows the powers of #sequence surveillance & #epidemiology💪

🆕 Blog! Our PhD student @eh-hayles.bsky.social discusses her research exploring and understanding how SARS-CoV-2 spread and evolved in #Norfolk during the COVID-19 pandemic 🦠

➡️ buff.ly/YgTTNVG

Congrats @eh-hayles.bsky.social ! And it's always nice to see that one can run 30k genomes on iqtree!

Genomic epidemiology of SARS-CoV-2 in Norfolk, UK, March 2020–December 2022 ReSay · Episode

Prefer to hear about the latest, awesome science in podcast summary instead of reading the entire paper?

Our @eh-hayles.bsky.social's @microbiologysociety.org paper has already been turned into a podcast episode!

Listen here or read the paper here www.microbiologyresearch.org/content/jour...

Genome sequencing SARS-CoV-2 plays a critical role in informing national and international COVID-19 public health responses - Quadram Institute Quadram Institute researchers contributed to genomic surveillance of COVID-19, supporting national and international response to the pandemic

During the #COVID19 pandemic @quadraminstitute.bsky.social, sequenced >87,000 #SARSCoV2 samples, with an emphasis on East Anglia, supporting local hospitals with data informed insights on the emerging pandemic with #COGUK. This paper explores the #genomic #epidemiology of SARS-CoV-2 in Norfolk, UK

Genomic epidemiology of SARS-CoV-2 in Norfolk, UK, March 2020–December 2022 In the UK, the COVID-19 Genomics UK Consortium (COG-UK) established a real-time national genomic surveillance system during the COVID-19 pandemic, producing centralized data for monitoring severe acut...

Truly delighted to see @eh-hayles.bsky.social have her 1st paper out! Not only 1st paper but 1st-1st author paper and 1st paper to ever come from the @mmbdtp.bsky.social!!!

Congratulations to you & all the co-authors👏Such a huge piece of work now in @microbiologysociety.org's #MicrobialGenomics

Key Highlights:
• 401 SARS-CoV-2 lineages detected across the pandemic
• 5 Variants of Concern IDed with Alpha, Delta & Omicron dominating
• 4 distinct regional epidemic waves
• Clear variation in wave patterns between different regions
• 1st paper to ever come from @mmbdtp.bsky.social

🥳🧬 #PhDlife

Genomic epidemiology of SARS-CoV-2 in Norfolk, UK, March 2020–December 2022 In the UK, the COVID-19 Genomics UK Consortium (COG-UK) established a real-time national genomic surveillance system during the COVID-19 pandemic, producing centralized data for monitoring severe acut...

Our @eh-hayles.bsky.social's 1st 1st-author paper is now published in @microbiologysociety.org's #MicrobialGenomics

It explores the #genomic #epidemiology of #COVID in Norfolk, UK

Great job by @andrewjpage.bsky.social @drrobkingsley.bsky.social Javier Guitian #COGUK & @gemma-langridge.bsky.social!

Whoops I fully got catch in the act of passionately discussing my science I3S Congress 🫣 What a great highlight reel! | Emma Waters Whoops I fully got catch in the act of passionately discussing my science I3S Congress 🫣 What a great highlight reel!

What a great movie reel of 3 incredible days of #Salmonella science & networking at #I3S #I3Scongress. A great highlight captured for us is @ukhsa.bsky.social's @mariechattaway.bsky.social vibrant keynote talk!

... & video evidence of our @emmabeansworth.bsky.social actually doing some work😮

The ability of @jidcuk.bsky.social to fund such projects depends on the resources we have today. Donations can help the charity expand their impact and support even more ground-breaking projects in the future. If you would like to support please donate here: www.jidcuk.org/donate