Amitesh Panda

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

We are excited to share our new preprint:

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.

www.biorxiv.org/content/10.64898/2025.12.01.691499v1

Our new preprint is out! 🎉

Happy and proud to have led this project during my PhD, and excited to share this story now as a preprint on bioRxiv.

Grateful to my amazing mentors for their guidance and support: @crougeulle.bsky.social , @jfouimette.bsky.social, @pasquelab.bsky.social

🔬 Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool!

👉 www.molgen.mpg.de/5098010/stei...

📢 Speaker showcase for our 2nd Meeting #Embryo2026 🧬Vincent Pasque @pasquelab.bsky.social from @kuleuvenuniversity.bsky.social will speak about his work on modelling early human embryogenesis with naïve pluripotent stem cells.
More information👇
www.molgen.mpg.de/embryo2026

Exciting Research Professorship Position in Stem Cell and Developmental Biology at the University of Leuven. Amazing research ecosystem, great colleagues, high quality of life, tenure track. For those interested in joining us, please see below:
www.kuleuven.be/personeel/jo...

#PhDDefense #BiomedicalSciences #DevelopmentalBiology #Epigenetics #StemCells #XChromosomeInactivation #Embryology #AcademicMilestone #PostdocSearch #LifeAsAPhD #ScienceLife #KULeuven

👨‍👩‍👧‍👦And of course, endless thanks to my family and friends and others. With that, I am now actively seeking exciting postdoctoral opportunities in the fields of developmental biology and epigenetics. Let’s connect!

👩‍⚖️ A heartfelt thanks to my PhD defense panel: Dr. Frederic Lluis, Dr. @leuccilrcb.bsky.social, Dr. Thorsten Boroviak, Dr. @maudborensztein.bsky.social, and Dr. Atilgan Yilmaz. I deeply appreciate your time, insightful questions, and valuable feedback.

🤝 Huge thanks to our collaborators: Dr. @crougeulle.bsky.social ,Dr. @jfouimette.bsky.social , Dr. @leo-carrillo.bsky.social , and all Rougeulle lab members; Dr. Frederic Lluis's lab; Dr. @nicolasrivron.bsky.social and others. 🙌

👨‍🏫 My deepest gratitude goes to my PI, Dr. Vincent Pasque @pasquelab.bsky.social , for his mentorship, trust, and constant support. To the entire Pasque Lab, thank you for being an incredible team and for your continued encouragement! 💙

🔬My research focused on how transcriptional and epigenetic regulation guide early human embryonic development, using stem cell–based embryo models and studying X-chromosome inactivation. This journey has been both an incredible challenge and a deeply rewarding experience. 🧠💭

🎓 PhD: Defended & Done! ✅
I am thrilled to share that I have successfully defended my PhD in Faculty of medicine, KU Leuven, Belgium! 🌟

Figure 1 Schematics of extra-embryonic mesoderm development across species. (A) An intermediate stage of reptilian development displaying the vascularized trilaminar omphalopleure, also known as choriovitelline membrane, and the bilaminar omphalopleure. (B) A later developmental stage in squamates, showing a feature unique to squamates: the yolk cleft. The composition of the amnion, allantois and chorion is similar in all reptiles. (C) E1 (24 h) chick embryo showing the primitive streak, area vitellina and vasculosa. (D) E10 chick embryo displaying the localization of vascularized and non-vascularized extra-embryonic mesoderm (EXM) cells.

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

🎉 Excited to see our review on extraembryonic mesoderm is out in @dev-journal.bsky.social! An often-overlooked but crucial lineage in early embryo development. Also happy that a tree was planted in the Forest of Biologists for this work! 🌱🌳

We have an opening for a Reviews Editor on Development. If you love developmental biology and its academic community, and have an interest in publishing and science communication, this could be the role for you. Full details here: www.biologists.com/wp-content/u...

Registration and abstract submission for YEN 2025 is officially open!

We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.

Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential Conventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-imp...

Exciting community effort for robust feeder-free maintenance of human naive pluripotent stem cells with blastoid formation potential. Collaboration with @grazianomartello.bsky.social, @leeboratory.bsky.social @jzylicz.bsky.social @nicolasrivron.bsky.social tinyurl.com/5n6z9rt9

It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!

📢 JOB VACANCY

4-Year Postdoc Position in Protein Design at @bristoluni.bsky.social

Develop new peptides and proteins to manipulate, target and probe the mechanisms that underpin intracellular transport by microtubule motors.

More: www.bristol.ac.uk/jobs/find-in...

Deadline: 6 Feb 2025

The transcription factor GABPA is a master regulator of naive pluripotency - Nature Cell Biology Zhang and colleagues identify the transcription factor GABPA as a regulator of zygotic genome activation, epiblast formation and naive pluripotency establishment.

NEW: Zhang & co identify the transcription factor GABPA as a regulator of #ZygoticGenomeActivation, epiblast formation and naive #pluripotency establishment.
www.nature.com/articles/s41...

YouTube video by OMGenomics RNA-seq tutorial with DESeq2: Differential gene expression project

🎁 New RNA-Seq tutorial! Learn to run differential expression analysis with DESeq2, and create your own bioinformatics projects using public data and the Expression Atlas 🧬 🖥️

youtu.be/NGbZmlGLG5w

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators Nature Cell Biology - Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and...

#NCB2024
In June, Liu, Xie & co profiled putative cis-regulatory elements in mouse #oocytes and pre-implantation #embryos. They further identified the transcription factors TCF3 and TCF12 as key regulators of #folliculogenesis.
rdcu.be/d3NiG
www.nature.com/articles/s41...

Registrations are open for the first edition of 'Gene regulation, one molecule at a time'! Very excited to bring #SingleMoleculeGenomics and #SingleMoleculeImaging community together @embl.org !
www.embl.org/about/info/c...

In Praise of Peer Review As an Editor of the journal Development, I often hear complaints about peer review. We all know the problems – from lengthy review times to requests for seemingly unnecessary experiments. I a…

I wrote some thoughts about why peer review matters

It shapes scientific standards, maintains field coherence & trains new researchers

Yes, it needs improvement—but it's the glue that holds scientific progress together

briscoelab.org/2024/12/11/i...

CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos The chick embryo is a classical model system commonly used in developmental biology due to its amenability to gene perturbation experiments. Pairing t…

Thrilled our plasmid-based CRISPR-Cas13d knockdown approach in chick embryos 🐣 is now In Press @devbiol.bsky.social !!

www.sciencedirect.com/science/arti...

Advert detailing a postdoctoral scientist position at EMBL Rome. Contact: jamie.hackett@embl.it

Postdoc positions in epigenetics!

We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms

Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️

See👇or contact me for other options. Pls RS